Identification of a novel anoikis signalling pathway using the fungal virulence factor gliotoxin
Gliotoxin (GT), produced by the pulmonary pathogen A. fumigatus, induces detachment-induced apoptosis (anoikis) of lung epithelial cells and likely promotes invasion. Here, the authors show that GT covalently modifies integrins at the RGD binding site followed by activation of RhoA-ROCK-MKK4/7-JNK s...
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Nature Portfolio
2018
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oai:doaj.org-article:bff8d4a17fd0485f978c20944875f2fe2021-12-02T14:39:48ZIdentification of a novel anoikis signalling pathway using the fungal virulence factor gliotoxin10.1038/s41467-018-05850-w2041-1723https://doaj.org/article/bff8d4a17fd0485f978c20944875f2fe2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05850-whttps://doaj.org/toc/2041-1723Gliotoxin (GT), produced by the pulmonary pathogen A. fumigatus, induces detachment-induced apoptosis (anoikis) of lung epithelial cells and likely promotes invasion. Here, the authors show that GT covalently modifies integrins at the RGD binding site followed by activation of RhoA-ROCK-MKK4/7-JNK signalling leading to Bim-mediated anoikis.Florian HaunSimon NeumannLukas PeintnerKatrin WielandJüri HabichtCarsten SchwanKristine ØstevoldMaria Magdalena KoczorowskaMartin BiniossekMatthias KistHauke BuschMelanie BoerriesRoger J. DavisUlrich MaurerOliver SchillingKlaus AktoriesChristoph BornerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Florian Haun Simon Neumann Lukas Peintner Katrin Wieland Jüri Habicht Carsten Schwan Kristine Østevold Maria Magdalena Koczorowska Martin Biniossek Matthias Kist Hauke Busch Melanie Boerries Roger J. Davis Ulrich Maurer Oliver Schilling Klaus Aktories Christoph Borner Identification of a novel anoikis signalling pathway using the fungal virulence factor gliotoxin |
| description |
Gliotoxin (GT), produced by the pulmonary pathogen A. fumigatus, induces detachment-induced apoptosis (anoikis) of lung epithelial cells and likely promotes invasion. Here, the authors show that GT covalently modifies integrins at the RGD binding site followed by activation of RhoA-ROCK-MKK4/7-JNK signalling leading to Bim-mediated anoikis. |
| format |
article |
| author |
Florian Haun Simon Neumann Lukas Peintner Katrin Wieland Jüri Habicht Carsten Schwan Kristine Østevold Maria Magdalena Koczorowska Martin Biniossek Matthias Kist Hauke Busch Melanie Boerries Roger J. Davis Ulrich Maurer Oliver Schilling Klaus Aktories Christoph Borner |
| author_facet |
Florian Haun Simon Neumann Lukas Peintner Katrin Wieland Jüri Habicht Carsten Schwan Kristine Østevold Maria Magdalena Koczorowska Martin Biniossek Matthias Kist Hauke Busch Melanie Boerries Roger J. Davis Ulrich Maurer Oliver Schilling Klaus Aktories Christoph Borner |
| author_sort |
Florian Haun |
| title |
Identification of a novel anoikis signalling pathway using the fungal virulence factor gliotoxin |
| title_short |
Identification of a novel anoikis signalling pathway using the fungal virulence factor gliotoxin |
| title_full |
Identification of a novel anoikis signalling pathway using the fungal virulence factor gliotoxin |
| title_fullStr |
Identification of a novel anoikis signalling pathway using the fungal virulence factor gliotoxin |
| title_full_unstemmed |
Identification of a novel anoikis signalling pathway using the fungal virulence factor gliotoxin |
| title_sort |
identification of a novel anoikis signalling pathway using the fungal virulence factor gliotoxin |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/bff8d4a17fd0485f978c20944875f2fe |
| work_keys_str_mv |
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| _version_ |
1718390499411230720 |