E3 ligase Nedd4l promotes antiviral innate immunity by catalyzing K29-linked cysteine ubiquitination of TRAF3

E3 ligase Nedd4l promotes antiviral innate immunity by catalyzing K29-linked cysteine ubiquitination of TRAF3

Ubiquitination is a prevalent post translational modification. Here, the authors show a pivotal role for Nedd4l in the regulation of antiviral immunity via promotion of ubiquitination of TRAF3 and go on to show disruption of Nedd4l both in vitro and in vivo perturbs the antiviral immune response.

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Auteurs principaux: Peng Gao, Xianwei Ma, Ming Yuan, Yulan Yi, Guoke Liu, Mingyue Wen, Wei Jiang, Ruihua Ji, Lingxi Zhu, Zhen Tang, Qingzhuo Yu, Jing Xu, Rui Yang, Sheng Xia, Mingjin Yang, Jianping Pan, Hongbin Yuan, Huazhang An
Format: article
Langue:EN
Publié: Nature Portfolio 2021
Sujets:
Science
Q
Accès en ligne:https://doaj.org/article/bffac75e109345e0b74fe29816ce9cfd
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Résumé:Ubiquitination is a prevalent post translational modification. Here, the authors show a pivotal role for Nedd4l in the regulation of antiviral immunity via promotion of ubiquitination of TRAF3 and go on to show disruption of Nedd4l both in vitro and in vivo perturbs the antiviral immune response.

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