E3 ligase Nedd4l promotes antiviral innate immunity by catalyzing K29-linked cysteine ubiquitination of TRAF3

Ubiquitination is a prevalent post translational modification. Here, the authors show a pivotal role for Nedd4l in the regulation of antiviral immunity via promotion of ubiquitination of TRAF3 and go on to show disruption of Nedd4l both in vitro and in vivo perturbs the antiviral immune response.

Guardado en:

Detalles Bibliográficos
Autores principales:	Peng Gao, Xianwei Ma, Ming Yuan, Yulan Yi, Guoke Liu, Mingyue Wen, Wei Jiang, Ruihua Ji, Lingxi Zhu, Zhen Tang, Qingzhuo Yu, Jing Xu, Rui Yang, Sheng Xia, Mingjin Yang, Jianping Pan, Hongbin Yuan, Huazhang An
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bffac75e109345e0b74fe29816ce9cfd
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:bffac75e109345e0b74fe29816ce9cfd
record_format	dspace
spelling	oai:doaj.org-article:bffac75e109345e0b74fe29816ce9cfd2021-12-02T12:11:11ZE3 ligase Nedd4l promotes antiviral innate immunity by catalyzing K29-linked cysteine ubiquitination of TRAF310.1038/s41467-021-21456-12041-1723https://doaj.org/article/bffac75e109345e0b74fe29816ce9cfd2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21456-1https://doaj.org/toc/2041-1723Ubiquitination is a prevalent post translational modification. Here, the authors show a pivotal role for Nedd4l in the regulation of antiviral immunity via promotion of ubiquitination of TRAF3 and go on to show disruption of Nedd4l both in vitro and in vivo perturbs the antiviral immune response.Peng GaoXianwei MaMing YuanYulan YiGuoke LiuMingyue WenWei JiangRuihua JiLingxi ZhuZhen TangQingzhuo YuJing XuRui YangSheng XiaMingjin YangJianping PanHongbin YuanHuazhang AnNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Peng Gao Xianwei Ma Ming Yuan Yulan Yi Guoke Liu Mingyue Wen Wei Jiang Ruihua Ji Lingxi Zhu Zhen Tang Qingzhuo Yu Jing Xu Rui Yang Sheng Xia Mingjin Yang Jianping Pan Hongbin Yuan Huazhang An E3 ligase Nedd4l promotes antiviral innate immunity by catalyzing K29-linked cysteine ubiquitination of TRAF3
description	Ubiquitination is a prevalent post translational modification. Here, the authors show a pivotal role for Nedd4l in the regulation of antiviral immunity via promotion of ubiquitination of TRAF3 and go on to show disruption of Nedd4l both in vitro and in vivo perturbs the antiviral immune response.
format	article
author	Peng Gao Xianwei Ma Ming Yuan Yulan Yi Guoke Liu Mingyue Wen Wei Jiang Ruihua Ji Lingxi Zhu Zhen Tang Qingzhuo Yu Jing Xu Rui Yang Sheng Xia Mingjin Yang Jianping Pan Hongbin Yuan Huazhang An
author_facet	Peng Gao Xianwei Ma Ming Yuan Yulan Yi Guoke Liu Mingyue Wen Wei Jiang Ruihua Ji Lingxi Zhu Zhen Tang Qingzhuo Yu Jing Xu Rui Yang Sheng Xia Mingjin Yang Jianping Pan Hongbin Yuan Huazhang An
author_sort	Peng Gao
title	E3 ligase Nedd4l promotes antiviral innate immunity by catalyzing K29-linked cysteine ubiquitination of TRAF3
title_short	E3 ligase Nedd4l promotes antiviral innate immunity by catalyzing K29-linked cysteine ubiquitination of TRAF3
title_full	E3 ligase Nedd4l promotes antiviral innate immunity by catalyzing K29-linked cysteine ubiquitination of TRAF3
title_fullStr	E3 ligase Nedd4l promotes antiviral innate immunity by catalyzing K29-linked cysteine ubiquitination of TRAF3
title_full_unstemmed	E3 ligase Nedd4l promotes antiviral innate immunity by catalyzing K29-linked cysteine ubiquitination of TRAF3
title_sort	e3 ligase nedd4l promotes antiviral innate immunity by catalyzing k29-linked cysteine ubiquitination of traf3
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bffac75e109345e0b74fe29816ce9cfd
work_keys_str_mv	AT penggao e3ligasenedd4lpromotesantiviralinnateimmunitybycatalyzingk29linkedcysteineubiquitinationoftraf3 AT xianweima e3ligasenedd4lpromotesantiviralinnateimmunitybycatalyzingk29linkedcysteineubiquitinationoftraf3 AT mingyuan e3ligasenedd4lpromotesantiviralinnateimmunitybycatalyzingk29linkedcysteineubiquitinationoftraf3 AT yulanyi e3ligasenedd4lpromotesantiviralinnateimmunitybycatalyzingk29linkedcysteineubiquitinationoftraf3 AT guokeliu e3ligasenedd4lpromotesantiviralinnateimmunitybycatalyzingk29linkedcysteineubiquitinationoftraf3 AT mingyuewen e3ligasenedd4lpromotesantiviralinnateimmunitybycatalyzingk29linkedcysteineubiquitinationoftraf3 AT weijiang e3ligasenedd4lpromotesantiviralinnateimmunitybycatalyzingk29linkedcysteineubiquitinationoftraf3 AT ruihuaji e3ligasenedd4lpromotesantiviralinnateimmunitybycatalyzingk29linkedcysteineubiquitinationoftraf3 AT lingxizhu e3ligasenedd4lpromotesantiviralinnateimmunitybycatalyzingk29linkedcysteineubiquitinationoftraf3 AT zhentang e3ligasenedd4lpromotesantiviralinnateimmunitybycatalyzingk29linkedcysteineubiquitinationoftraf3 AT qingzhuoyu e3ligasenedd4lpromotesantiviralinnateimmunitybycatalyzingk29linkedcysteineubiquitinationoftraf3 AT jingxu e3ligasenedd4lpromotesantiviralinnateimmunitybycatalyzingk29linkedcysteineubiquitinationoftraf3 AT ruiyang e3ligasenedd4lpromotesantiviralinnateimmunitybycatalyzingk29linkedcysteineubiquitinationoftraf3 AT shengxia e3ligasenedd4lpromotesantiviralinnateimmunitybycatalyzingk29linkedcysteineubiquitinationoftraf3 AT mingjinyang e3ligasenedd4lpromotesantiviralinnateimmunitybycatalyzingk29linkedcysteineubiquitinationoftraf3 AT jianpingpan e3ligasenedd4lpromotesantiviralinnateimmunitybycatalyzingk29linkedcysteineubiquitinationoftraf3 AT hongbinyuan e3ligasenedd4lpromotesantiviralinnateimmunitybycatalyzingk29linkedcysteineubiquitinationoftraf3 AT huazhangan e3ligasenedd4lpromotesantiviralinnateimmunitybycatalyzingk29linkedcysteineubiquitinationoftraf3
_version_	1718394655067865088

E3 ligase Nedd4l promotes antiviral innate immunity by catalyzing K29-linked cysteine ubiquitination of TRAF3

Ejemplares similares