Stepwise low concentration atropine for myopic control: a 10-year cohort study

Abstract The aim of this study was to analyze changes in refraction and evaluate the variables in school children who received atropine as myopic control for 10 years. Low-concentration atropine (0.05%) was prescribed initially, and the dose was increased in a stepwise manner if rapid myopic progres...

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Autores principales:	Meng-Ni Chuang, Po-Chiung Fang, Pei-Chang Wu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c002b5f27bb941b18d32a25b8ce5a57c
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spelling	oai:doaj.org-article:c002b5f27bb941b18d32a25b8ce5a57c2021-12-02T16:38:25ZStepwise low concentration atropine for myopic control: a 10-year cohort study10.1038/s41598-021-96698-62045-2322https://doaj.org/article/c002b5f27bb941b18d32a25b8ce5a57c2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96698-6https://doaj.org/toc/2045-2322Abstract The aim of this study was to analyze changes in refraction and evaluate the variables in school children who received atropine as myopic control for 10 years. Low-concentration atropine (0.05%) was prescribed initially, and the dose was increased in a stepwise manner if rapid myopic progression (≥ 0.5D per half year) was noted during the regular follow-up visit. 23 children with a mean age of 6.96 ± 1.07 years were included. The initial spherical equivalent was − 1.25 ± 0.84 D. The overall mean myopic progression was − 0.30 ± 0.27 D/year. Younger initial age, female, higher initial spherical equivalent and the need of higher concentration of atropine were found to be risk factors for myopic progression in multivariate mixed-effect analysis (p = 0.013, 0.017, 0.024 and 0.014). Children who kept using a lower concentration of atropine (≤ 0.1%) tended to have slower myopic progression throughout the 10-year course than those who shifted to higher concentrations (> 0.1%) (p ≤ 0.001). Stepwise low concentration of atropine might be effective for long-term myopic control in school students. Those who had poor response to lower concentration of atropine may have the risk of faster progression, even with high concentration of atropine. Additional or alternative treatment might be considered.Meng-Ni ChuangPo-Chiung FangPei-Chang WuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Meng-Ni Chuang Po-Chiung Fang Pei-Chang Wu Stepwise low concentration atropine for myopic control: a 10-year cohort study
description	Abstract The aim of this study was to analyze changes in refraction and evaluate the variables in school children who received atropine as myopic control for 10 years. Low-concentration atropine (0.05%) was prescribed initially, and the dose was increased in a stepwise manner if rapid myopic progression (≥ 0.5D per half year) was noted during the regular follow-up visit. 23 children with a mean age of 6.96 ± 1.07 years were included. The initial spherical equivalent was − 1.25 ± 0.84 D. The overall mean myopic progression was − 0.30 ± 0.27 D/year. Younger initial age, female, higher initial spherical equivalent and the need of higher concentration of atropine were found to be risk factors for myopic progression in multivariate mixed-effect analysis (p = 0.013, 0.017, 0.024 and 0.014). Children who kept using a lower concentration of atropine (≤ 0.1%) tended to have slower myopic progression throughout the 10-year course than those who shifted to higher concentrations (> 0.1%) (p ≤ 0.001). Stepwise low concentration of atropine might be effective for long-term myopic control in school students. Those who had poor response to lower concentration of atropine may have the risk of faster progression, even with high concentration of atropine. Additional or alternative treatment might be considered.
format	article
author	Meng-Ni Chuang Po-Chiung Fang Pei-Chang Wu
author_facet	Meng-Ni Chuang Po-Chiung Fang Pei-Chang Wu
author_sort	Meng-Ni Chuang
title	Stepwise low concentration atropine for myopic control: a 10-year cohort study
title_short	Stepwise low concentration atropine for myopic control: a 10-year cohort study
title_full	Stepwise low concentration atropine for myopic control: a 10-year cohort study
title_fullStr	Stepwise low concentration atropine for myopic control: a 10-year cohort study
title_full_unstemmed	Stepwise low concentration atropine for myopic control: a 10-year cohort study
title_sort	stepwise low concentration atropine for myopic control: a 10-year cohort study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c002b5f27bb941b18d32a25b8ce5a57c
work_keys_str_mv	AT mengnichuang stepwiselowconcentrationatropineformyopiccontrola10yearcohortstudy AT pochiungfang stepwiselowconcentrationatropineformyopiccontrola10yearcohortstudy AT peichangwu stepwiselowconcentrationatropineformyopiccontrola10yearcohortstudy
_version_	1718383598845820928

Stepwise low concentration atropine for myopic control: a 10-year cohort study

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