Feeding-induced resistance to acute lethal sepsis is dependent on hepatic BMAL1 and FXR signalling

Time of day influences immune responses and lethality in response to LPS, with survival greatest at the beginning compared to the end of the light cycle. Here the authors show that feeding, rather than light, controls time-of-day dependent LPS sensitivity through the liver clock and hepatic FXR sign...

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Autores principales: Sarah S. Geiger, Javier Traba, Nathan Richoz, Taylor K. Farley, Stephen R. Brooks, Franziska Petermann, Lingdi Wang, Frank J. Gonzalez, Michael N. Sack, Richard M. Siegel
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/c006a892d73b44e6afaa5d1292253d77
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Sumario:Time of day influences immune responses and lethality in response to LPS, with survival greatest at the beginning compared to the end of the light cycle. Here the authors show that feeding, rather than light, controls time-of-day dependent LPS sensitivity through the liver clock and hepatic FXR signalling.