Feeding-induced resistance to acute lethal sepsis is dependent on hepatic BMAL1 and FXR signalling

Time of day influences immune responses and lethality in response to LPS, with survival greatest at the beginning compared to the end of the light cycle. Here the authors show that feeding, rather than light, controls time-of-day dependent LPS sensitivity through the liver clock and hepatic FXR sign...

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Autores principales:	Sarah S. Geiger, Javier Traba, Nathan Richoz, Taylor K. Farley, Stephen R. Brooks, Franziska Petermann, Lingdi Wang, Frank J. Gonzalez, Michael N. Sack, Richard M. Siegel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c006a892d73b44e6afaa5d1292253d77
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spelling	oai:doaj.org-article:c006a892d73b44e6afaa5d1292253d772021-12-02T15:43:16ZFeeding-induced resistance to acute lethal sepsis is dependent on hepatic BMAL1 and FXR signalling10.1038/s41467-021-22961-z2041-1723https://doaj.org/article/c006a892d73b44e6afaa5d1292253d772021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22961-zhttps://doaj.org/toc/2041-1723Time of day influences immune responses and lethality in response to LPS, with survival greatest at the beginning compared to the end of the light cycle. Here the authors show that feeding, rather than light, controls time-of-day dependent LPS sensitivity through the liver clock and hepatic FXR signalling.Sarah S. GeigerJavier TrabaNathan RichozTaylor K. FarleyStephen R. BrooksFranziska PetermannLingdi WangFrank J. GonzalezMichael N. SackRichard M. SiegelNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sarah S. Geiger Javier Traba Nathan Richoz Taylor K. Farley Stephen R. Brooks Franziska Petermann Lingdi Wang Frank J. Gonzalez Michael N. Sack Richard M. Siegel Feeding-induced resistance to acute lethal sepsis is dependent on hepatic BMAL1 and FXR signalling
description	Time of day influences immune responses and lethality in response to LPS, with survival greatest at the beginning compared to the end of the light cycle. Here the authors show that feeding, rather than light, controls time-of-day dependent LPS sensitivity through the liver clock and hepatic FXR signalling.
format	article
author	Sarah S. Geiger Javier Traba Nathan Richoz Taylor K. Farley Stephen R. Brooks Franziska Petermann Lingdi Wang Frank J. Gonzalez Michael N. Sack Richard M. Siegel
author_facet	Sarah S. Geiger Javier Traba Nathan Richoz Taylor K. Farley Stephen R. Brooks Franziska Petermann Lingdi Wang Frank J. Gonzalez Michael N. Sack Richard M. Siegel
author_sort	Sarah S. Geiger
title	Feeding-induced resistance to acute lethal sepsis is dependent on hepatic BMAL1 and FXR signalling
title_short	Feeding-induced resistance to acute lethal sepsis is dependent on hepatic BMAL1 and FXR signalling
title_full	Feeding-induced resistance to acute lethal sepsis is dependent on hepatic BMAL1 and FXR signalling
title_fullStr	Feeding-induced resistance to acute lethal sepsis is dependent on hepatic BMAL1 and FXR signalling
title_full_unstemmed	Feeding-induced resistance to acute lethal sepsis is dependent on hepatic BMAL1 and FXR signalling
title_sort	feeding-induced resistance to acute lethal sepsis is dependent on hepatic bmal1 and fxr signalling
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c006a892d73b44e6afaa5d1292253d77
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Feeding-induced resistance to acute lethal sepsis is dependent on hepatic BMAL1 and FXR signalling

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