Increased overall cortical connectivity with syndrome specific local decreases suggested by atypical sleep-EEG synchronization in Williams syndrome

Abstract Williams syndrome (7q11.23 microdeletion) is characterized by specific alterations in neurocognitive architecture and functioning, as well as disordered sleep. Here we analyze the region, sleep state and frequency-specific EEG synchronization of whole night sleep recordings of 21 Williams s...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ferenc Gombos, Róbert Bódizs, Ilona Kovács
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c008701fe52f497093403eee720e7754
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c008701fe52f497093403eee720e7754
record_format	dspace
spelling	oai:doaj.org-article:c008701fe52f497093403eee720e77542021-12-02T16:06:23ZIncreased overall cortical connectivity with syndrome specific local decreases suggested by atypical sleep-EEG synchronization in Williams syndrome10.1038/s41598-017-06280-22045-2322https://doaj.org/article/c008701fe52f497093403eee720e77542017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06280-2https://doaj.org/toc/2045-2322Abstract Williams syndrome (7q11.23 microdeletion) is characterized by specific alterations in neurocognitive architecture and functioning, as well as disordered sleep. Here we analyze the region, sleep state and frequency-specific EEG synchronization of whole night sleep recordings of 21 Williams syndrome and 21 typically developing age- and gender-matched subjects by calculating weighted phase lag indexes. We found broadband increases in inter- and intrahemispheric neural connectivity for both NREM and REM sleep EEG of Williams syndrome subjects. These effects consisted of increased theta, high sigma, and beta/low gamma synchronization, whereas alpha synchronization was characterized by a peculiar Williams syndrome-specific decrease during NREM states (intra- and interhemispheric centro-temporal) and REM phases of sleep (occipital intra-area synchronization). We also found a decrease in short range, occipital connectivity of NREM sleep EEG theta activity. The striking increased overall synchronization of sleep EEG in Williams syndrome subjects is consistent with the recently reported increase in synaptic and dendritic density in stem-cell based Williams syndrome models, whereas decreased alpha and occipital connectivity might reflect and underpin the altered microarchitecture of primary visual cortex and disordered visuospatial functioning of Williams syndrome subjects.Ferenc GombosRóbert BódizsIlona KovácsNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ferenc Gombos Róbert Bódizs Ilona Kovács Increased overall cortical connectivity with syndrome specific local decreases suggested by atypical sleep-EEG synchronization in Williams syndrome
description	Abstract Williams syndrome (7q11.23 microdeletion) is characterized by specific alterations in neurocognitive architecture and functioning, as well as disordered sleep. Here we analyze the region, sleep state and frequency-specific EEG synchronization of whole night sleep recordings of 21 Williams syndrome and 21 typically developing age- and gender-matched subjects by calculating weighted phase lag indexes. We found broadband increases in inter- and intrahemispheric neural connectivity for both NREM and REM sleep EEG of Williams syndrome subjects. These effects consisted of increased theta, high sigma, and beta/low gamma synchronization, whereas alpha synchronization was characterized by a peculiar Williams syndrome-specific decrease during NREM states (intra- and interhemispheric centro-temporal) and REM phases of sleep (occipital intra-area synchronization). We also found a decrease in short range, occipital connectivity of NREM sleep EEG theta activity. The striking increased overall synchronization of sleep EEG in Williams syndrome subjects is consistent with the recently reported increase in synaptic and dendritic density in stem-cell based Williams syndrome models, whereas decreased alpha and occipital connectivity might reflect and underpin the altered microarchitecture of primary visual cortex and disordered visuospatial functioning of Williams syndrome subjects.
format	article
author	Ferenc Gombos Róbert Bódizs Ilona Kovács
author_facet	Ferenc Gombos Róbert Bódizs Ilona Kovács
author_sort	Ferenc Gombos
title	Increased overall cortical connectivity with syndrome specific local decreases suggested by atypical sleep-EEG synchronization in Williams syndrome
title_short	Increased overall cortical connectivity with syndrome specific local decreases suggested by atypical sleep-EEG synchronization in Williams syndrome
title_full	Increased overall cortical connectivity with syndrome specific local decreases suggested by atypical sleep-EEG synchronization in Williams syndrome
title_fullStr	Increased overall cortical connectivity with syndrome specific local decreases suggested by atypical sleep-EEG synchronization in Williams syndrome
title_full_unstemmed	Increased overall cortical connectivity with syndrome specific local decreases suggested by atypical sleep-EEG synchronization in Williams syndrome
title_sort	increased overall cortical connectivity with syndrome specific local decreases suggested by atypical sleep-eeg synchronization in williams syndrome
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c008701fe52f497093403eee720e7754
work_keys_str_mv	AT ferencgombos increasedoverallcorticalconnectivitywithsyndromespecificlocaldecreasessuggestedbyatypicalsleepeegsynchronizationinwilliamssyndrome AT robertbodizs increasedoverallcorticalconnectivitywithsyndromespecificlocaldecreasessuggestedbyatypicalsleepeegsynchronizationinwilliamssyndrome AT ilonakovacs increasedoverallcorticalconnectivitywithsyndromespecificlocaldecreasessuggestedbyatypicalsleepeegsynchronizationinwilliamssyndrome
_version_	1718385050762870784

Increased overall cortical connectivity with syndrome specific local decreases suggested by atypical sleep-EEG synchronization in Williams syndrome

Ejemplares similares