Multi-scale modeling toolbox for single neuron and subcellular activity under Transcranial Magnetic Stimulation

Background: Transcranial Magnetic Stimulation (TMS) is a widely used non-invasive brain stimulation method. However, its mechanism of action and the neural response to TMS are still poorly understood. Multi-scale modeling can complement experimental research to study the subcellular neural effects o...

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Autores principales:	Sina Shirinpour, Nicholas Hananeia, James Rosado, Harry Tran, Christos Galanis, Andreas Vlachos, Peter Jedlicka, Gillian Queisser, Alexander Opitz
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Transcranial magnetic stimulation Electric field simulation Neuron compartmental modeling Calcium simulation Three-dimensional reconstructions Synaptic plasticity Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/c00d76e3d22541688b20d7db17549401
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spelling	oai:doaj.org-article:c00d76e3d22541688b20d7db175494012021-11-20T04:58:26ZMulti-scale modeling toolbox for single neuron and subcellular activity under Transcranial Magnetic Stimulation1935-861X10.1016/j.brs.2021.09.004https://doaj.org/article/c00d76e3d22541688b20d7db175494012021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1935861X21002345https://doaj.org/toc/1935-861XBackground: Transcranial Magnetic Stimulation (TMS) is a widely used non-invasive brain stimulation method. However, its mechanism of action and the neural response to TMS are still poorly understood. Multi-scale modeling can complement experimental research to study the subcellular neural effects of TMS. At the macroscopic level, sophisticated numerical models exist to estimate the induced electric fields. However, multi-scale computational modeling approaches to predict TMS cellular and subcellular responses, crucial to understanding TMS plasticity inducing protocols, are not available so far. Objective: We develop an open-source multi-scale toolbox Neuron Modeling for TMS (NeMo-TMS) to address this problem. Methods: NeMo-TMS generates accurate neuron models from morphological reconstructions, couples them to the external electric fields induced by TMS, and simulates the cellular and subcellular responses of single-pulse and repetitive TMS. Results: We provide examples showing some of the capabilities of the toolbox. Conclusion: NeMo-TMS toolbox allows researchers a previously not available level of detail and precision in realistically modeling the physical and physiological effects of TMS.Sina ShirinpourNicholas HananeiaJames RosadoHarry TranChristos GalanisAndreas VlachosPeter JedlickaGillian QueisserAlexander OpitzElsevierarticleTranscranial magnetic stimulationElectric field simulationNeuron compartmental modelingCalcium simulationThree-dimensional reconstructionsSynaptic plasticityNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENBrain Stimulation, Vol 14, Iss 6, Pp 1470-1482 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Transcranial magnetic stimulation Electric field simulation Neuron compartmental modeling Calcium simulation Three-dimensional reconstructions Synaptic plasticity Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Transcranial magnetic stimulation Electric field simulation Neuron compartmental modeling Calcium simulation Three-dimensional reconstructions Synaptic plasticity Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Sina Shirinpour Nicholas Hananeia James Rosado Harry Tran Christos Galanis Andreas Vlachos Peter Jedlicka Gillian Queisser Alexander Opitz Multi-scale modeling toolbox for single neuron and subcellular activity under Transcranial Magnetic Stimulation
description	Background: Transcranial Magnetic Stimulation (TMS) is a widely used non-invasive brain stimulation method. However, its mechanism of action and the neural response to TMS are still poorly understood. Multi-scale modeling can complement experimental research to study the subcellular neural effects of TMS. At the macroscopic level, sophisticated numerical models exist to estimate the induced electric fields. However, multi-scale computational modeling approaches to predict TMS cellular and subcellular responses, crucial to understanding TMS plasticity inducing protocols, are not available so far. Objective: We develop an open-source multi-scale toolbox Neuron Modeling for TMS (NeMo-TMS) to address this problem. Methods: NeMo-TMS generates accurate neuron models from morphological reconstructions, couples them to the external electric fields induced by TMS, and simulates the cellular and subcellular responses of single-pulse and repetitive TMS. Results: We provide examples showing some of the capabilities of the toolbox. Conclusion: NeMo-TMS toolbox allows researchers a previously not available level of detail and precision in realistically modeling the physical and physiological effects of TMS.
format	article
author	Sina Shirinpour Nicholas Hananeia James Rosado Harry Tran Christos Galanis Andreas Vlachos Peter Jedlicka Gillian Queisser Alexander Opitz
author_facet	Sina Shirinpour Nicholas Hananeia James Rosado Harry Tran Christos Galanis Andreas Vlachos Peter Jedlicka Gillian Queisser Alexander Opitz
author_sort	Sina Shirinpour
title	Multi-scale modeling toolbox for single neuron and subcellular activity under Transcranial Magnetic Stimulation
title_short	Multi-scale modeling toolbox for single neuron and subcellular activity under Transcranial Magnetic Stimulation
title_full	Multi-scale modeling toolbox for single neuron and subcellular activity under Transcranial Magnetic Stimulation
title_fullStr	Multi-scale modeling toolbox for single neuron and subcellular activity under Transcranial Magnetic Stimulation
title_full_unstemmed	Multi-scale modeling toolbox for single neuron and subcellular activity under Transcranial Magnetic Stimulation
title_sort	multi-scale modeling toolbox for single neuron and subcellular activity under transcranial magnetic stimulation
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/c00d76e3d22541688b20d7db17549401
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Multi-scale modeling toolbox for single neuron and subcellular activity under Transcranial Magnetic Stimulation

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