Docetaxel-loaded multilayer nanoparticles with nanodroplets for cancer therapy

Keun Sang Oh,1,* Kyungim Kim,1,* Byeong Deok Yoon,1 Hye Jin Lee,1 Dal Yong Park,1 Eun-yeong Kim,1 Kiho Lee,1 Jae Hong Seo,2 Soon Hong Yuk1,2 1College of Pharmacy, Korea University, Sejong, 2Biomedical Research Center, Korea University Guro Hospital, Guro-gu, Seoul, Republic of Korea *These authors...

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Autores principales:	Oh KS, Kim KI, Yoon BD, Lee HJ, Park DY, Kim EY, Lee K, Seo JH, Yuk SH
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Multilayer nanoparticles Solutol Pluronic F-68 Docetaxel Cancer therapy Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/c0130dda0bcc4482bd4c6aede607004a
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spelling	oai:doaj.org-article:c0130dda0bcc4482bd4c6aede607004a2021-12-02T07:22:59ZDocetaxel-loaded multilayer nanoparticles with nanodroplets for cancer therapy1178-2013https://doaj.org/article/c0130dda0bcc4482bd4c6aede607004a2016-03-01T00:00:00Zhttps://www.dovepress.com/docetaxel-loaded-multilayer-nanoparticles-with-nanodroplets-for-cancer-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Keun Sang Oh,1,* Kyungim Kim,1,* Byeong Deok Yoon,1 Hye Jin Lee,1 Dal Yong Park,1 Eun-yeong Kim,1 Kiho Lee,1 Jae Hong Seo,2 Soon Hong Yuk1,2 1College of Pharmacy, Korea University, Sejong, 2Biomedical Research Center, Korea University Guro Hospital, Guro-gu, Seoul, Republic of Korea *These authors contributed equally to this work Abstract: A mixture of docetaxel (DTX) and Solutol® HS 15 (Solutol) transiently formed nanodroplets when it was suspended in an aqueous medium. However, nanodroplets that comprised DTX and Solutol showed a rapid precipitation of DTX because of their unstable characteristics in the aqueous medium. The incorporation of nanodroplets that comprised DTX and Solutol through vesicle fusion and subsequent stabilization was designed to prepare multilayer nanoparticles (NPs) with a DTX-loaded Solutol nanodroplet (as template NPs) core for an efficient delivery of DTX as a chemotherapeutic drug. As a result, the DTX-loaded Solutol nanodroplets (~11.7 nm) were observed to have an increased average diameter (from 11.7 nm to 156.1 nm) and a good stability of the hydrated NPs without precipitation of DTX by vesicle fusion and multilayered structure, respectively. Also, a long circulation of the multilayer NPs was observed, and this was due to the presence of Pluronic F-68 on the surface of the multilayer NPs. This led to an improved antitumor efficacy based on the enhanced permeation and retention effect. Therefore, this study indicated that the multilayer NPs have a considerable potential as a drug delivery system with an enhanced therapeutic efficacy by blood circulation and with low side effects. Keywords: multilayer nanoparticles, Solutol, Pluronic F-68, docetaxel, cancer therapyOh KSKim KIYoon BDLee HJPark DYKim EYLee KSeo JHYuk SHDove Medical PressarticleMultilayer nanoparticlesSolutolPluronic F-68DocetaxelCancer therapyMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2016, Iss default, Pp 1077-1087 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Multilayer nanoparticles Solutol Pluronic F-68 Docetaxel Cancer therapy Medicine (General) R5-920
spellingShingle	Multilayer nanoparticles Solutol Pluronic F-68 Docetaxel Cancer therapy Medicine (General) R5-920 Oh KS Kim KI Yoon BD Lee HJ Park DY Kim EY Lee K Seo JH Yuk SH Docetaxel-loaded multilayer nanoparticles with nanodroplets for cancer therapy
description	Keun Sang Oh,1,* Kyungim Kim,1,* Byeong Deok Yoon,1 Hye Jin Lee,1 Dal Yong Park,1 Eun-yeong Kim,1 Kiho Lee,1 Jae Hong Seo,2 Soon Hong Yuk1,2 1College of Pharmacy, Korea University, Sejong, 2Biomedical Research Center, Korea University Guro Hospital, Guro-gu, Seoul, Republic of Korea *These authors contributed equally to this work Abstract: A mixture of docetaxel (DTX) and Solutol® HS 15 (Solutol) transiently formed nanodroplets when it was suspended in an aqueous medium. However, nanodroplets that comprised DTX and Solutol showed a rapid precipitation of DTX because of their unstable characteristics in the aqueous medium. The incorporation of nanodroplets that comprised DTX and Solutol through vesicle fusion and subsequent stabilization was designed to prepare multilayer nanoparticles (NPs) with a DTX-loaded Solutol nanodroplet (as template NPs) core for an efficient delivery of DTX as a chemotherapeutic drug. As a result, the DTX-loaded Solutol nanodroplets (~11.7 nm) were observed to have an increased average diameter (from 11.7 nm to 156.1 nm) and a good stability of the hydrated NPs without precipitation of DTX by vesicle fusion and multilayered structure, respectively. Also, a long circulation of the multilayer NPs was observed, and this was due to the presence of Pluronic F-68 on the surface of the multilayer NPs. This led to an improved antitumor efficacy based on the enhanced permeation and retention effect. Therefore, this study indicated that the multilayer NPs have a considerable potential as a drug delivery system with an enhanced therapeutic efficacy by blood circulation and with low side effects. Keywords: multilayer nanoparticles, Solutol, Pluronic F-68, docetaxel, cancer therapy
format	article
author	Oh KS Kim KI Yoon BD Lee HJ Park DY Kim EY Lee K Seo JH Yuk SH
author_facet	Oh KS Kim KI Yoon BD Lee HJ Park DY Kim EY Lee K Seo JH Yuk SH
author_sort	Oh KS
title	Docetaxel-loaded multilayer nanoparticles with nanodroplets for cancer therapy
title_short	Docetaxel-loaded multilayer nanoparticles with nanodroplets for cancer therapy
title_full	Docetaxel-loaded multilayer nanoparticles with nanodroplets for cancer therapy
title_fullStr	Docetaxel-loaded multilayer nanoparticles with nanodroplets for cancer therapy
title_full_unstemmed	Docetaxel-loaded multilayer nanoparticles with nanodroplets for cancer therapy
title_sort	docetaxel-loaded multilayer nanoparticles with nanodroplets for cancer therapy
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/c0130dda0bcc4482bd4c6aede607004a
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Docetaxel-loaded multilayer nanoparticles with nanodroplets for cancer therapy

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