CD160 serves as a negative regulator of NKT cells in acute hepatic injury

BTLA is established as a negative regulator of natural killer T (NKT) cell function, and share its ligand HVEM with CD160. Here the authors show, by analyzing NKT activation in CD160-deficient mice or with BTLA blockade, that CD160 synergizes with BTLA to negatively regulate NKT cells during hepatic...

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Autores principales:	Tae-Jin Kim, Gayoung Park, Jeongmin Kim, Seon Ah Lim, Jiyoung Kim, Kyungtaek Im, Min Hwa Shin, Yang-Xin Fu, Maria-Luisa Del Rio, Jose-Ignacio Rodriguez-Barbosa, Cassian Yee, Kyung-Suk Suh, Seong-Jin Kim, Sang-Jun Ha, Kyung-Mi Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c01494c358d541df8aa8b760a2cb9a37
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spelling	oai:doaj.org-article:c01494c358d541df8aa8b760a2cb9a372021-12-02T14:35:55ZCD160 serves as a negative regulator of NKT cells in acute hepatic injury10.1038/s41467-019-10320-y2041-1723https://doaj.org/article/c01494c358d541df8aa8b760a2cb9a372019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10320-yhttps://doaj.org/toc/2041-1723BTLA is established as a negative regulator of natural killer T (NKT) cell function, and share its ligand HVEM with CD160. Here the authors show, by analyzing NKT activation in CD160-deficient mice or with BTLA blockade, that CD160 synergizes with BTLA to negatively regulate NKT cells during hepatic injury.Tae-Jin KimGayoung ParkJeongmin KimSeon Ah LimJiyoung KimKyungtaek ImMin Hwa ShinYang-Xin FuMaria-Luisa Del RioJose-Ignacio Rodriguez-BarbosaCassian YeeKyung-Suk SuhSeong-Jin KimSang-Jun HaKyung-Mi LeeNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tae-Jin Kim Gayoung Park Jeongmin Kim Seon Ah Lim Jiyoung Kim Kyungtaek Im Min Hwa Shin Yang-Xin Fu Maria-Luisa Del Rio Jose-Ignacio Rodriguez-Barbosa Cassian Yee Kyung-Suk Suh Seong-Jin Kim Sang-Jun Ha Kyung-Mi Lee CD160 serves as a negative regulator of NKT cells in acute hepatic injury
description	BTLA is established as a negative regulator of natural killer T (NKT) cell function, and share its ligand HVEM with CD160. Here the authors show, by analyzing NKT activation in CD160-deficient mice or with BTLA blockade, that CD160 synergizes with BTLA to negatively regulate NKT cells during hepatic injury.
format	article
author	Tae-Jin Kim Gayoung Park Jeongmin Kim Seon Ah Lim Jiyoung Kim Kyungtaek Im Min Hwa Shin Yang-Xin Fu Maria-Luisa Del Rio Jose-Ignacio Rodriguez-Barbosa Cassian Yee Kyung-Suk Suh Seong-Jin Kim Sang-Jun Ha Kyung-Mi Lee
author_facet	Tae-Jin Kim Gayoung Park Jeongmin Kim Seon Ah Lim Jiyoung Kim Kyungtaek Im Min Hwa Shin Yang-Xin Fu Maria-Luisa Del Rio Jose-Ignacio Rodriguez-Barbosa Cassian Yee Kyung-Suk Suh Seong-Jin Kim Sang-Jun Ha Kyung-Mi Lee
author_sort	Tae-Jin Kim
title	CD160 serves as a negative regulator of NKT cells in acute hepatic injury
title_short	CD160 serves as a negative regulator of NKT cells in acute hepatic injury
title_full	CD160 serves as a negative regulator of NKT cells in acute hepatic injury
title_fullStr	CD160 serves as a negative regulator of NKT cells in acute hepatic injury
title_full_unstemmed	CD160 serves as a negative regulator of NKT cells in acute hepatic injury
title_sort	cd160 serves as a negative regulator of nkt cells in acute hepatic injury
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/c01494c358d541df8aa8b760a2cb9a37
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CD160 serves as a negative regulator of NKT cells in acute hepatic injury

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