Specialization of gene expression during mouse brain development.

The transcriptome of the brain changes during development, reflecting processes that determine functional specialization of brain regions. We analyzed gene expression, measured using in situ hybridization across the full developing mouse brain, to quantify functional specialization of brain regions....

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Autores principales:	Noa Liscovitch, Gal Chechik
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/c0182a313f4f443b90eedf4f055f58c8
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spelling	oai:doaj.org-article:c0182a313f4f443b90eedf4f055f58c82021-11-18T05:53:35ZSpecialization of gene expression during mouse brain development.1553-734X1553-735810.1371/journal.pcbi.1003185https://doaj.org/article/c0182a313f4f443b90eedf4f055f58c82013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24068900/pdf/?tool=EBIhttps://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358The transcriptome of the brain changes during development, reflecting processes that determine functional specialization of brain regions. We analyzed gene expression, measured using in situ hybridization across the full developing mouse brain, to quantify functional specialization of brain regions. Surprisingly, we found that during the time that the brain becomes anatomically regionalized in early development, transcription specialization actually decreases reaching a low, "neurotypic", point around birth. This decrease of specialization is brain-wide, and mainly due to biological processes involved in constructing brain circuitry. Regional specialization rises again during post-natal development. This effect is largely due to specialization of plasticity and neural activity processes. Post-natal specialization is particularly significant in the cerebellum, whose expression signature becomes increasingly different from other brain regions. When comparing mouse and human expression patterns, the cerebellar post-natal specialization is also observed in human, but the regionalization of expression in the human Thalamus and Cortex follows a strikingly different profile than in mouse.Noa LiscovitchGal ChechikPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 9, Iss 9, p e1003185 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Noa Liscovitch Gal Chechik Specialization of gene expression during mouse brain development.
description	The transcriptome of the brain changes during development, reflecting processes that determine functional specialization of brain regions. We analyzed gene expression, measured using in situ hybridization across the full developing mouse brain, to quantify functional specialization of brain regions. Surprisingly, we found that during the time that the brain becomes anatomically regionalized in early development, transcription specialization actually decreases reaching a low, "neurotypic", point around birth. This decrease of specialization is brain-wide, and mainly due to biological processes involved in constructing brain circuitry. Regional specialization rises again during post-natal development. This effect is largely due to specialization of plasticity and neural activity processes. Post-natal specialization is particularly significant in the cerebellum, whose expression signature becomes increasingly different from other brain regions. When comparing mouse and human expression patterns, the cerebellar post-natal specialization is also observed in human, but the regionalization of expression in the human Thalamus and Cortex follows a strikingly different profile than in mouse.
format	article
author	Noa Liscovitch Gal Chechik
author_facet	Noa Liscovitch Gal Chechik
author_sort	Noa Liscovitch
title	Specialization of gene expression during mouse brain development.
title_short	Specialization of gene expression during mouse brain development.
title_full	Specialization of gene expression during mouse brain development.
title_fullStr	Specialization of gene expression during mouse brain development.
title_full_unstemmed	Specialization of gene expression during mouse brain development.
title_sort	specialization of gene expression during mouse brain development.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/c0182a313f4f443b90eedf4f055f58c8
work_keys_str_mv	AT noaliscovitch specializationofgeneexpressionduringmousebraindevelopment AT galchechik specializationofgeneexpressionduringmousebraindevelopment
_version_	1718424691161432064

Specialization of gene expression during mouse brain development.

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