Classical non-homologous end-joining pathway utilizes nascent RNA for error-free double-strand break repair of transcribed genes

Most adult mammalian cells prefer to repair double-strand DNA breaks though the classical nonhomologous end-joining pathway. Here the authors present evidence that a nascent RNA transcript can serve as a template to facilitate error-free repair.

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Autores principales:	Anirban Chakraborty, Nisha Tapryal, Tatiana Venkova, Nobuo Horikoshi, Raj K. Pandita, Altaf H. Sarker, Partha S. Sarkar, Tej K. Pandita, Tapas K. Hazra
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c0190224ff2c4b5b97ae064cba887a7a
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spelling	oai:doaj.org-article:c0190224ff2c4b5b97ae064cba887a7a2021-12-02T14:39:52ZClassical non-homologous end-joining pathway utilizes nascent RNA for error-free double-strand break repair of transcribed genes10.1038/ncomms130492041-1723https://doaj.org/article/c0190224ff2c4b5b97ae064cba887a7a2016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms13049https://doaj.org/toc/2041-1723Most adult mammalian cells prefer to repair double-strand DNA breaks though the classical nonhomologous end-joining pathway. Here the authors present evidence that a nascent RNA transcript can serve as a template to facilitate error-free repair.Anirban ChakrabortyNisha TapryalTatiana VenkovaNobuo HorikoshiRaj K. PanditaAltaf H. SarkerPartha S. SarkarTej K. PanditaTapas K. HazraNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anirban Chakraborty Nisha Tapryal Tatiana Venkova Nobuo Horikoshi Raj K. Pandita Altaf H. Sarker Partha S. Sarkar Tej K. Pandita Tapas K. Hazra Classical non-homologous end-joining pathway utilizes nascent RNA for error-free double-strand break repair of transcribed genes
description	Most adult mammalian cells prefer to repair double-strand DNA breaks though the classical nonhomologous end-joining pathway. Here the authors present evidence that a nascent RNA transcript can serve as a template to facilitate error-free repair.
format	article
author	Anirban Chakraborty Nisha Tapryal Tatiana Venkova Nobuo Horikoshi Raj K. Pandita Altaf H. Sarker Partha S. Sarkar Tej K. Pandita Tapas K. Hazra
author_facet	Anirban Chakraborty Nisha Tapryal Tatiana Venkova Nobuo Horikoshi Raj K. Pandita Altaf H. Sarker Partha S. Sarkar Tej K. Pandita Tapas K. Hazra
author_sort	Anirban Chakraborty
title	Classical non-homologous end-joining pathway utilizes nascent RNA for error-free double-strand break repair of transcribed genes
title_short	Classical non-homologous end-joining pathway utilizes nascent RNA for error-free double-strand break repair of transcribed genes
title_full	Classical non-homologous end-joining pathway utilizes nascent RNA for error-free double-strand break repair of transcribed genes
title_fullStr	Classical non-homologous end-joining pathway utilizes nascent RNA for error-free double-strand break repair of transcribed genes
title_full_unstemmed	Classical non-homologous end-joining pathway utilizes nascent RNA for error-free double-strand break repair of transcribed genes
title_sort	classical non-homologous end-joining pathway utilizes nascent rna for error-free double-strand break repair of transcribed genes
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/c0190224ff2c4b5b97ae064cba887a7a
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Classical non-homologous end-joining pathway utilizes nascent RNA for error-free double-strand break repair of transcribed genes

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