DUSP5 functions as a feedback regulator of TNFα-induced ERK1/2 dephosphorylation and inflammatory gene expression in adipocytes

Abstract Adipose tissue inflammation is a central pathological element that regulates obesity-mediated insulin resistance and type II diabetes. Evidence demonstrates that extracellular signal-regulated kinase (ERK 1/2) activation (i.e. phosphorylation) links tumor necrosis factor α (TNFα) to pro-inf...

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Autores principales: Justine S. Habibian, Mitra Jefic, Rushita A. Bagchi, Robert H. Lane, Robert A. McKnight, Timothy A. McKinsey, Ron F. Morrison, Bradley S. Ferguson
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/c01c36ef8be84d84a14c081f4ea2159f
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