Activin signaling is an essential component of the TGF-β induced pro-metastatic phenotype in colorectal cancer

Abstract Advanced colorectal cancer (CRC) remains a critical health care challenge worldwide. Various TGF-β superfamily members are important in colorectal cancer metastasis, but their signaling effects and predictive value have only been assessed in isolation. Here, we examine cross-regulation and...

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Autores principales:	Jonas J. Staudacher, Jessica Bauer, Arundhati Jana, Jun Tian, Timothy Carroll, Georgina Mancinelli, Özkan Özden, Nancy Krett, Grace Guzman, David Kerr, Paul Grippo, Barbara Jung
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c01c74d63eaa498fb7379bdbd225836e
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spelling	oai:doaj.org-article:c01c74d63eaa498fb7379bdbd225836e2021-12-02T16:06:35ZActivin signaling is an essential component of the TGF-β induced pro-metastatic phenotype in colorectal cancer10.1038/s41598-017-05907-82045-2322https://doaj.org/article/c01c74d63eaa498fb7379bdbd225836e2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05907-8https://doaj.org/toc/2045-2322Abstract Advanced colorectal cancer (CRC) remains a critical health care challenge worldwide. Various TGF-β superfamily members are important in colorectal cancer metastasis, but their signaling effects and predictive value have only been assessed in isolation. Here, we examine cross-regulation and combined functions of the two most prominent TGF-β superfamily members activin and TGF-β in advanced colorectal cancer. In two clinical cohorts we observed by immune-based assay that combined serum and tissue activin and TGF-β ligand levels predicts outcome in CRC patients and is superior to single ligand assessment. While TGF-β growth suppression is independent of activin, TGF-β treatment leads to increased activin secretion in colon cancer cells and TGF-β induced cellular migration is dependent on activin, indicating pathway cross-regulation and functional interaction in vitro. mRNA expression of activin and TGF-β pathway members were queried in silico using the TCGA data set. Coordinated ligand and receptor expression is common in solid tumors for activin and TGF-β pathway members. In conclusion, activin and TGF-β are strongly connected signaling pathways that are important in advanced CRC. Assessing activin and TGF-β signaling as a unit yields important insights applicable to future diagnostic and therapeutic interventions.Jonas J. StaudacherJessica BauerArundhati JanaJun TianTimothy CarrollGeorgina MancinelliÖzkan ÖzdenNancy KrettGrace GuzmanDavid KerrPaul GrippoBarbara JungNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jonas J. Staudacher Jessica Bauer Arundhati Jana Jun Tian Timothy Carroll Georgina Mancinelli Özkan Özden Nancy Krett Grace Guzman David Kerr Paul Grippo Barbara Jung Activin signaling is an essential component of the TGF-β induced pro-metastatic phenotype in colorectal cancer
description	Abstract Advanced colorectal cancer (CRC) remains a critical health care challenge worldwide. Various TGF-β superfamily members are important in colorectal cancer metastasis, but their signaling effects and predictive value have only been assessed in isolation. Here, we examine cross-regulation and combined functions of the two most prominent TGF-β superfamily members activin and TGF-β in advanced colorectal cancer. In two clinical cohorts we observed by immune-based assay that combined serum and tissue activin and TGF-β ligand levels predicts outcome in CRC patients and is superior to single ligand assessment. While TGF-β growth suppression is independent of activin, TGF-β treatment leads to increased activin secretion in colon cancer cells and TGF-β induced cellular migration is dependent on activin, indicating pathway cross-regulation and functional interaction in vitro. mRNA expression of activin and TGF-β pathway members were queried in silico using the TCGA data set. Coordinated ligand and receptor expression is common in solid tumors for activin and TGF-β pathway members. In conclusion, activin and TGF-β are strongly connected signaling pathways that are important in advanced CRC. Assessing activin and TGF-β signaling as a unit yields important insights applicable to future diagnostic and therapeutic interventions.
format	article
author	Jonas J. Staudacher Jessica Bauer Arundhati Jana Jun Tian Timothy Carroll Georgina Mancinelli Özkan Özden Nancy Krett Grace Guzman David Kerr Paul Grippo Barbara Jung
author_facet	Jonas J. Staudacher Jessica Bauer Arundhati Jana Jun Tian Timothy Carroll Georgina Mancinelli Özkan Özden Nancy Krett Grace Guzman David Kerr Paul Grippo Barbara Jung
author_sort	Jonas J. Staudacher
title	Activin signaling is an essential component of the TGF-β induced pro-metastatic phenotype in colorectal cancer
title_short	Activin signaling is an essential component of the TGF-β induced pro-metastatic phenotype in colorectal cancer
title_full	Activin signaling is an essential component of the TGF-β induced pro-metastatic phenotype in colorectal cancer
title_fullStr	Activin signaling is an essential component of the TGF-β induced pro-metastatic phenotype in colorectal cancer
title_full_unstemmed	Activin signaling is an essential component of the TGF-β induced pro-metastatic phenotype in colorectal cancer
title_sort	activin signaling is an essential component of the tgf-β induced pro-metastatic phenotype in colorectal cancer
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c01c74d63eaa498fb7379bdbd225836e
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Activin signaling is an essential component of the TGF-β induced pro-metastatic phenotype in colorectal cancer

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