Semen may harbor HIV despite effective HAART: another piece in the puzzle.

<h4>Background</h4>The risk of male-to-female intravaginal HIV-1 transmission is estimated at about 1 event per 200-2000 coital acts. The aim of this study was to assess the residual risk of HIV presence in semen in patients under HAART therapy.<h4>Methods and findings</h4>Th...

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Autores principales:	Philippe Halfon, Claude Giorgetti, Hacène Khiri, Guillaume Pénaranda, Philippe Terriou, Géraldine Porcu-Buisson, Véronique Chabert-Orsini
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c01e4b328ad1416d9ab44928bf630611
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spelling	oai:doaj.org-article:c01e4b328ad1416d9ab44928bf6306112021-12-02T20:21:42ZSemen may harbor HIV despite effective HAART: another piece in the puzzle.1932-620310.1371/journal.pone.0010569https://doaj.org/article/c01e4b328ad1416d9ab44928bf6306112010-05-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20485526/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>The risk of male-to-female intravaginal HIV-1 transmission is estimated at about 1 event per 200-2000 coital acts. The aim of this study was to assess the residual risk of HIV presence in semen in patients under HAART therapy.<h4>Methods and findings</h4>The study took place in France from October 2001 to March 2009. 394 paired blood and semen samples were provided from 332 HIV-1 infected men. The Roche Cobas AMPLICOR Monitor HIV assay was used to quantify HIV-1 RNA in blood and in seminal plasma. Three percent of 394 HIV-1 infected men enrolled in an assisted reproductive technology program harbored detectable HIV-1 RNA in semen, although they had no other sexually transmitted disease and their blood viral load was undetectable for at least 6 months under antiretroviral treatment.<h4>Conclusion</h4>These data suggest that undetectable plasma HIV RNA means a lower risk of viral transmission through seminal fluid on a population level, but not necessarily at the level of the individual.Philippe HalfonClaude GiorgettiHacène KhiriGuillaume PénarandaPhilippe TerriouGéraldine Porcu-BuissonVéronique Chabert-OrsiniPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 5, p e10569 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Philippe Halfon Claude Giorgetti Hacène Khiri Guillaume Pénaranda Philippe Terriou Géraldine Porcu-Buisson Véronique Chabert-Orsini Semen may harbor HIV despite effective HAART: another piece in the puzzle.
description	<h4>Background</h4>The risk of male-to-female intravaginal HIV-1 transmission is estimated at about 1 event per 200-2000 coital acts. The aim of this study was to assess the residual risk of HIV presence in semen in patients under HAART therapy.<h4>Methods and findings</h4>The study took place in France from October 2001 to March 2009. 394 paired blood and semen samples were provided from 332 HIV-1 infected men. The Roche Cobas AMPLICOR Monitor HIV assay was used to quantify HIV-1 RNA in blood and in seminal plasma. Three percent of 394 HIV-1 infected men enrolled in an assisted reproductive technology program harbored detectable HIV-1 RNA in semen, although they had no other sexually transmitted disease and their blood viral load was undetectable for at least 6 months under antiretroviral treatment.<h4>Conclusion</h4>These data suggest that undetectable plasma HIV RNA means a lower risk of viral transmission through seminal fluid on a population level, but not necessarily at the level of the individual.
format	article
author	Philippe Halfon Claude Giorgetti Hacène Khiri Guillaume Pénaranda Philippe Terriou Géraldine Porcu-Buisson Véronique Chabert-Orsini
author_facet	Philippe Halfon Claude Giorgetti Hacène Khiri Guillaume Pénaranda Philippe Terriou Géraldine Porcu-Buisson Véronique Chabert-Orsini
author_sort	Philippe Halfon
title	Semen may harbor HIV despite effective HAART: another piece in the puzzle.
title_short	Semen may harbor HIV despite effective HAART: another piece in the puzzle.
title_full	Semen may harbor HIV despite effective HAART: another piece in the puzzle.
title_fullStr	Semen may harbor HIV despite effective HAART: another piece in the puzzle.
title_full_unstemmed	Semen may harbor HIV despite effective HAART: another piece in the puzzle.
title_sort	semen may harbor hiv despite effective haart: another piece in the puzzle.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/c01e4b328ad1416d9ab44928bf630611
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Semen may harbor HIV despite effective HAART: another piece in the puzzle.

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