Genetically Engineered Live-Attenuated Middle East Respiratory Syndrome Coronavirus Viruses Confer Full Protection against Lethal Infection

The emergence of the new highly pathogenic human coronavirus SARS-CoV-2 that has already infected more than 80 million persons, killing nearly two million of them, clearly indicates the need to design efficient and safe vaccines protecting from these coronaviruses. Modern vaccines can be derived fr...

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Autores principales:	Javier Gutiérrez-Álvarez, José M. Honrubia, Raúl Fernández-Delgado, Li Wang, Carlos Castaño-Rodríguez, Sonia Zúñiga, Isabel Sola, Luis Enjuanes
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2021
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/c01fb9a68b5a453eacd5373a7db07a1d
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spelling	oai:doaj.org-article:c01fb9a68b5a453eacd5373a7db07a1d2021-11-03T18:56:09ZGenetically Engineered Live-Attenuated Middle East Respiratory Syndrome Coronavirus Viruses Confer Full Protection against Lethal Infection2150-751110.1128/mBio.00103-21https://doaj.org/article/c01fb9a68b5a453eacd5373a7db07a1d2021-04-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00103-21https://doaj.org/toc/2150-7511 The emergence of the new highly pathogenic human coronavirus SARS-CoV-2 that has already infected more than 80 million persons, killing nearly two million of them, clearly indicates the need to design efficient and safe vaccines protecting from these coronaviruses. Modern vaccines can be derived from virus-host interaction research directed to the identification of signaling pathways essential for virus replication and for virus-induced pathogenesis, in order to learn how to attenuate these viruses and design vaccines.Javier Gutiérrez-ÁlvarezJosé M. HonrubiaRaúl Fernández-DelgadoLi WangCarlos Castaño-RodríguezSonia ZúñigaIsabel SolaLuis EnjuanesAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 12, Iss 2 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Javier Gutiérrez-Álvarez José M. Honrubia Raúl Fernández-Delgado Li Wang Carlos Castaño-Rodríguez Sonia Zúñiga Isabel Sola Luis Enjuanes Genetically Engineered Live-Attenuated Middle East Respiratory Syndrome Coronavirus Viruses Confer Full Protection against Lethal Infection
description	The emergence of the new highly pathogenic human coronavirus SARS-CoV-2 that has already infected more than 80 million persons, killing nearly two million of them, clearly indicates the need to design efficient and safe vaccines protecting from these coronaviruses. Modern vaccines can be derived from virus-host interaction research directed to the identification of signaling pathways essential for virus replication and for virus-induced pathogenesis, in order to learn how to attenuate these viruses and design vaccines.
format	article
author	Javier Gutiérrez-Álvarez José M. Honrubia Raúl Fernández-Delgado Li Wang Carlos Castaño-Rodríguez Sonia Zúñiga Isabel Sola Luis Enjuanes
author_facet	Javier Gutiérrez-Álvarez José M. Honrubia Raúl Fernández-Delgado Li Wang Carlos Castaño-Rodríguez Sonia Zúñiga Isabel Sola Luis Enjuanes
author_sort	Javier Gutiérrez-Álvarez
title	Genetically Engineered Live-Attenuated Middle East Respiratory Syndrome Coronavirus Viruses Confer Full Protection against Lethal Infection
title_short	Genetically Engineered Live-Attenuated Middle East Respiratory Syndrome Coronavirus Viruses Confer Full Protection against Lethal Infection
title_full	Genetically Engineered Live-Attenuated Middle East Respiratory Syndrome Coronavirus Viruses Confer Full Protection against Lethal Infection
title_fullStr	Genetically Engineered Live-Attenuated Middle East Respiratory Syndrome Coronavirus Viruses Confer Full Protection against Lethal Infection
title_full_unstemmed	Genetically Engineered Live-Attenuated Middle East Respiratory Syndrome Coronavirus Viruses Confer Full Protection against Lethal Infection
title_sort	genetically engineered live-attenuated middle east respiratory syndrome coronavirus viruses confer full protection against lethal infection
publisher	American Society for Microbiology
publishDate	2021
url	https://doaj.org/article/c01fb9a68b5a453eacd5373a7db07a1d
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Genetically Engineered Live-Attenuated Middle East Respiratory Syndrome Coronavirus Viruses Confer Full Protection against Lethal Infection

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