Dynamic Virulence: Real-Time Assessment of Intracellular Pathogenesis Links <named-content content-type="genus-species">Cryptococcus neoformans</named-content> Phenotype with Clinical Outcome

ABSTRACT While a myriad of studies have examined host factors that predispose persons to infection with the opportunistic fungal pathogen Cryptococcus neoformans, comparatively little has been done to examine how virulence factor differences among cryptococcal isolates may impact outcome. In the rec...

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Autores principales:	Michael K. Mansour, Jatin M. Vyas, Stuart M. Levitz
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2011
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/c0252fad4e824ab58d9aebc9b2671c54
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spelling	oai:doaj.org-article:c0252fad4e824ab58d9aebc9b2671c542021-11-15T15:38:58ZDynamic Virulence: Real-Time Assessment of Intracellular Pathogenesis Links <named-content content-type="genus-species">Cryptococcus neoformans</named-content> Phenotype with Clinical Outcome10.1128/mBio.00217-112150-7511https://doaj.org/article/c0252fad4e824ab58d9aebc9b2671c542011-11-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00217-11https://doaj.org/toc/2150-7511ABSTRACT While a myriad of studies have examined host factors that predispose persons to infection with the opportunistic fungal pathogen Cryptococcus neoformans, comparatively little has been done to examine how virulence factor differences among cryptococcal isolates may impact outcome. In the recent report by Alanio et al. (A. Alanio, M. Desnos-Ollivier, and F. Dromer, mBio 2:e00158-11, 2011), novel flow cytometry-based techniques were employed to demonstrate an association between the phenotype of C. neoformans-macrophage interactions, as measured by phagocytosis and intracellular replication, and patient outcomes, as determined by positive cultures on therapy and survival. These experiments establish that the prognosis of patients with cryptococcosis is influenced by the phenotypic properties of the infecting fungal isolate.Michael K. MansourJatin M. VyasStuart M. LevitzAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 2, Iss 5 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Michael K. Mansour Jatin M. Vyas Stuart M. Levitz Dynamic Virulence: Real-Time Assessment of Intracellular Pathogenesis Links <named-content content-type="genus-species">Cryptococcus neoformans</named-content> Phenotype with Clinical Outcome
description	ABSTRACT While a myriad of studies have examined host factors that predispose persons to infection with the opportunistic fungal pathogen Cryptococcus neoformans, comparatively little has been done to examine how virulence factor differences among cryptococcal isolates may impact outcome. In the recent report by Alanio et al. (A. Alanio, M. Desnos-Ollivier, and F. Dromer, mBio 2:e00158-11, 2011), novel flow cytometry-based techniques were employed to demonstrate an association between the phenotype of C. neoformans-macrophage interactions, as measured by phagocytosis and intracellular replication, and patient outcomes, as determined by positive cultures on therapy and survival. These experiments establish that the prognosis of patients with cryptococcosis is influenced by the phenotypic properties of the infecting fungal isolate.
format	article
author	Michael K. Mansour Jatin M. Vyas Stuart M. Levitz
author_facet	Michael K. Mansour Jatin M. Vyas Stuart M. Levitz
author_sort	Michael K. Mansour
title	Dynamic Virulence: Real-Time Assessment of Intracellular Pathogenesis Links <named-content content-type="genus-species">Cryptococcus neoformans</named-content> Phenotype with Clinical Outcome
title_short	Dynamic Virulence: Real-Time Assessment of Intracellular Pathogenesis Links <named-content content-type="genus-species">Cryptococcus neoformans</named-content> Phenotype with Clinical Outcome
title_full	Dynamic Virulence: Real-Time Assessment of Intracellular Pathogenesis Links <named-content content-type="genus-species">Cryptococcus neoformans</named-content> Phenotype with Clinical Outcome
title_fullStr	Dynamic Virulence: Real-Time Assessment of Intracellular Pathogenesis Links <named-content content-type="genus-species">Cryptococcus neoformans</named-content> Phenotype with Clinical Outcome
title_full_unstemmed	Dynamic Virulence: Real-Time Assessment of Intracellular Pathogenesis Links <named-content content-type="genus-species">Cryptococcus neoformans</named-content> Phenotype with Clinical Outcome
title_sort	dynamic virulence: real-time assessment of intracellular pathogenesis links <named-content content-type="genus-species">cryptococcus neoformans</named-content> phenotype with clinical outcome
publisher	American Society for Microbiology
publishDate	2011
url	https://doaj.org/article/c0252fad4e824ab58d9aebc9b2671c54
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Dynamic Virulence: Real-Time Assessment of Intracellular Pathogenesis Links <named-content content-type="genus-species">Cryptococcus neoformans</named-content> Phenotype with Clinical Outcome

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