Diffusion tensor imaging investigations in Alzheimer’s disease: the resurgence of white matter compromise in the cortical dysfunction of the aging brain
David A Medina1, Moises Gaviria21Department of Psychiatry, Case Western Reserve University, Cleveland, OH, USA; 2University of Illinois at Chicago, IL, USAAbstract: Diffusion tensor imaging (DTI) is a sophisticated MRI-based neuroimaging technique that enables in vivo quantifi cation of differences...
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Dove Medical Press
2008
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oai:doaj.org-article:c0277a18013246b7b240c382e6a5a2da2021-12-02T00:40:32ZDiffusion tensor imaging investigations in Alzheimer’s disease: the resurgence of white matter compromise in the cortical dysfunction of the aging brain1176-63281178-2021https://doaj.org/article/c0277a18013246b7b240c382e6a5a2da2008-09-01T00:00:00Zhttp://www.dovepress.com/diffusion-tensor-imaging-investigations-in-alzheimerrsquos-disease-the-a2199https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021David A Medina1, Moises Gaviria21Department of Psychiatry, Case Western Reserve University, Cleveland, OH, USA; 2University of Illinois at Chicago, IL, USAAbstract: Diffusion tensor imaging (DTI) is a sophisticated MRI-based neuroimaging technique that enables in vivo quantifi cation of differences in molecular diffusion at the cellular level. Owing to the highly directional architecture of white matter (WM), DTI is providing important clues of the structure and geometric organization of this neural compartment. Since DTI can detect changes even in the case of radiologically “normal” appearing WM, researchers are using the technique for the study of WM integrity at the initial stages of the most common neurodegenerative disorders. Along with a well characterized cortical pathology (neuritic plaques and intracellular neurofibrillary tangles), WM changes have been also demonstrated in Alzheimer’s disease (AD). However, these changes had been for years found nonliable in the onset and progress of AD, basically due to lack of incriminatory evidence. The use of novel tools such as DTI has enabled the anatomical distribution of WM microstructural damage in the prodromal stages of AD to be gauged and determined, granting a long-delayed protagonic role to WM in the natural history of this highly prevalent neurodegenerative condition.Keywords: diffusion, DTI, white matter, Alzheimer’s disease, aging, anisotropy David A MedinaMoises GaviriaDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2008, Iss Issue 4, Pp 737-742 (2008) |
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Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
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Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 David A Medina Moises Gaviria Diffusion tensor imaging investigations in Alzheimer’s disease: the resurgence of white matter compromise in the cortical dysfunction of the aging brain |
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David A Medina1, Moises Gaviria21Department of Psychiatry, Case Western Reserve University, Cleveland, OH, USA; 2University of Illinois at Chicago, IL, USAAbstract: Diffusion tensor imaging (DTI) is a sophisticated MRI-based neuroimaging technique that enables in vivo quantifi cation of differences in molecular diffusion at the cellular level. Owing to the highly directional architecture of white matter (WM), DTI is providing important clues of the structure and geometric organization of this neural compartment. Since DTI can detect changes even in the case of radiologically “normal” appearing WM, researchers are using the technique for the study of WM integrity at the initial stages of the most common neurodegenerative disorders. Along with a well characterized cortical pathology (neuritic plaques and intracellular neurofibrillary tangles), WM changes have been also demonstrated in Alzheimer’s disease (AD). However, these changes had been for years found nonliable in the onset and progress of AD, basically due to lack of incriminatory evidence. The use of novel tools such as DTI has enabled the anatomical distribution of WM microstructural damage in the prodromal stages of AD to be gauged and determined, granting a long-delayed protagonic role to WM in the natural history of this highly prevalent neurodegenerative condition.Keywords: diffusion, DTI, white matter, Alzheimer’s disease, aging, anisotropy |
format |
article |
author |
David A Medina Moises Gaviria |
author_facet |
David A Medina Moises Gaviria |
author_sort |
David A Medina |
title |
Diffusion tensor imaging investigations in Alzheimer’s disease: the resurgence of white matter compromise in the cortical dysfunction of the aging brain |
title_short |
Diffusion tensor imaging investigations in Alzheimer’s disease: the resurgence of white matter compromise in the cortical dysfunction of the aging brain |
title_full |
Diffusion tensor imaging investigations in Alzheimer’s disease: the resurgence of white matter compromise in the cortical dysfunction of the aging brain |
title_fullStr |
Diffusion tensor imaging investigations in Alzheimer’s disease: the resurgence of white matter compromise in the cortical dysfunction of the aging brain |
title_full_unstemmed |
Diffusion tensor imaging investigations in Alzheimer’s disease: the resurgence of white matter compromise in the cortical dysfunction of the aging brain |
title_sort |
diffusion tensor imaging investigations in alzheimer’s disease: the resurgence of white matter compromise in the cortical dysfunction of the aging brain |
publisher |
Dove Medical Press |
publishDate |
2008 |
url |
https://doaj.org/article/c0277a18013246b7b240c382e6a5a2da |
work_keys_str_mv |
AT davidamedina diffusiontensorimaginginvestigationsinalzheimeramprsquosdiseasetheresurgenceofwhitemattercompromiseinampnbspthecorticaldysfunctionoftheagingbrain AT moisesgaviria diffusiontensorimaginginvestigationsinalzheimeramprsquosdiseasetheresurgenceofwhitemattercompromiseinampnbspthecorticaldysfunctionoftheagingbrain |
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1718403579561115648 |