Diffusion tensor imaging investigations in Alzheimer’s disease: the resurgence of white matter compromise in the cortical dysfunction of the aging brain

David A Medina1, Moises Gaviria21Department of Psychiatry, Case Western Reserve University, Cleveland, OH, USA; 2University of Illinois at Chicago, IL, USAAbstract: Diffusion tensor imaging (DTI) is a sophisticated MRI-based neuroimaging technique that enables in vivo quantifi cation of differences...

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Autores principales: David A Medina, Moises Gaviria
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Publicado: Dove Medical Press 2008
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spelling oai:doaj.org-article:c0277a18013246b7b240c382e6a5a2da2021-12-02T00:40:32ZDiffusion tensor imaging investigations in Alzheimer’s disease: the resurgence of white matter compromise in the cortical dysfunction of the aging brain1176-63281178-2021https://doaj.org/article/c0277a18013246b7b240c382e6a5a2da2008-09-01T00:00:00Zhttp://www.dovepress.com/diffusion-tensor-imaging-investigations-in-alzheimerrsquos-disease-the-a2199https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021David A Medina1, Moises Gaviria21Department of Psychiatry, Case Western Reserve University, Cleveland, OH, USA; 2University of Illinois at Chicago, IL, USAAbstract: Diffusion tensor imaging (DTI) is a sophisticated MRI-based neuroimaging technique that enables in vivo quantifi cation of differences in molecular diffusion at the cellular level. Owing to the highly directional architecture of white matter (WM), DTI is providing important clues of the structure and geometric organization of this neural compartment. Since DTI can detect changes even in the case of radiologically “normal” appearing WM, researchers are using the technique for the study of WM integrity at the initial stages of the most common neurodegenerative disorders. Along with a well characterized cortical pathology (neuritic plaques and intracellular neurofibrillary tangles), WM changes have been also demonstrated in Alzheimer’s disease (AD). However, these changes had been for years found nonliable in the onset and progress of AD, basically due to lack of incriminatory evidence. The use of novel tools such as DTI has enabled the anatomical distribution of WM microstructural damage in the prodromal stages of AD to be gauged and determined, granting a long-delayed protagonic role to WM in the natural history of this highly prevalent neurodegenerative condition.Keywords: diffusion, DTI, white matter, Alzheimer’s disease, aging, anisotropy David A MedinaMoises GaviriaDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2008, Iss Issue 4, Pp 737-742 (2008)
institution DOAJ
collection DOAJ
language EN
topic Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
spellingShingle Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
David A Medina
Moises Gaviria
Diffusion tensor imaging investigations in Alzheimer’s disease: the resurgence of white matter compromise in the cortical dysfunction of the aging brain
description David A Medina1, Moises Gaviria21Department of Psychiatry, Case Western Reserve University, Cleveland, OH, USA; 2University of Illinois at Chicago, IL, USAAbstract: Diffusion tensor imaging (DTI) is a sophisticated MRI-based neuroimaging technique that enables in vivo quantifi cation of differences in molecular diffusion at the cellular level. Owing to the highly directional architecture of white matter (WM), DTI is providing important clues of the structure and geometric organization of this neural compartment. Since DTI can detect changes even in the case of radiologically “normal” appearing WM, researchers are using the technique for the study of WM integrity at the initial stages of the most common neurodegenerative disorders. Along with a well characterized cortical pathology (neuritic plaques and intracellular neurofibrillary tangles), WM changes have been also demonstrated in Alzheimer’s disease (AD). However, these changes had been for years found nonliable in the onset and progress of AD, basically due to lack of incriminatory evidence. The use of novel tools such as DTI has enabled the anatomical distribution of WM microstructural damage in the prodromal stages of AD to be gauged and determined, granting a long-delayed protagonic role to WM in the natural history of this highly prevalent neurodegenerative condition.Keywords: diffusion, DTI, white matter, Alzheimer’s disease, aging, anisotropy
format article
author David A Medina
Moises Gaviria
author_facet David A Medina
Moises Gaviria
author_sort David A Medina
title Diffusion tensor imaging investigations in Alzheimer’s disease: the resurgence of white matter compromise in the cortical dysfunction of the aging brain
title_short Diffusion tensor imaging investigations in Alzheimer’s disease: the resurgence of white matter compromise in the cortical dysfunction of the aging brain
title_full Diffusion tensor imaging investigations in Alzheimer’s disease: the resurgence of white matter compromise in the cortical dysfunction of the aging brain
title_fullStr Diffusion tensor imaging investigations in Alzheimer’s disease: the resurgence of white matter compromise in the cortical dysfunction of the aging brain
title_full_unstemmed Diffusion tensor imaging investigations in Alzheimer’s disease: the resurgence of white matter compromise in the cortical dysfunction of the aging brain
title_sort diffusion tensor imaging investigations in alzheimer’s disease: the resurgence of white matter compromise in the cortical dysfunction of the aging brain
publisher Dove Medical Press
publishDate 2008
url https://doaj.org/article/c0277a18013246b7b240c382e6a5a2da
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