Chemical components, pharmacological properties, and nanoparticulate delivery systems of Brucea javanica

Meiwan Chen,1,&Dagger; Ruie Chen,1,&Dagger; Shengpeng Wang,1 Wen Tan,1 Yangyang Hu,1 Xinsheng Peng,2 Yitao Wang11State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China; 2School of Pharmaceutical Sciences,...

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Autores principales:	Peng X, Hu Y, Tan W, Wang S, Chen R, Chen M, Wang Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/c02f4bbeceff41068b5003117056c0b8
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spelling	oai:doaj.org-article:c02f4bbeceff41068b5003117056c0b82021-12-02T09:08:48ZChemical components, pharmacological properties, and nanoparticulate delivery systems of Brucea javanica1176-91141178-2013https://doaj.org/article/c02f4bbeceff41068b5003117056c0b82013-01-01T00:00:00Zhttp://www.dovepress.com/chemical-components-pharmacological-properties-and-nanoparticulate-del-a11851https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Meiwan Chen,1,&Dagger; Ruie Chen,1,&Dagger; Shengpeng Wang,1 Wen Tan,1 Yangyang Hu,1 Xinsheng Peng,2 Yitao Wang11State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China; 2School of Pharmaceutical Sciences, Guangdong Medical College, Dongguan, China&Dagger;These authors contributed equally to this workAbstract: Brucea javanica has demonstrated a variety of antitumoral, antimalarial, and anti-inflammatory properties. As a Chinese herbal medicine, Brucea javanica is mainly used in the treatment of lung and gastrointestinal cancers. Pharmacological research has identified the main antitumor components are tetracyclic triterpene quassinoids. However, most of these active components have poor water solubility and low bioavailability, which greatly limit their clinical application. Nanoparticulate delivery systems are urgently needed to improve the bioavailability of Brucea javanica. This paper mainly focuses on the chemical components in Brucea javanica and its pharmacological properties and nanoparticulate formulations, in an attempt to encourage further research on its active components and nanoparticulate drug delivery systems to expand its clinical applications. It is expected to improve the level of pharmaceutical research and provide a strong scientific foundation for further study on the medicinal properties of this plant.Keywords: Brucea javanica, chemical components, pharmacology, nanoparticulate delivery systemsPeng XHu YTan WWang SChen RChen MWang YDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2013, Iss default, Pp 85-92 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Peng X Hu Y Tan W Wang S Chen R Chen M Wang Y Chemical components, pharmacological properties, and nanoparticulate delivery systems of Brucea javanica
description	Meiwan Chen,1,&Dagger; Ruie Chen,1,&Dagger; Shengpeng Wang,1 Wen Tan,1 Yangyang Hu,1 Xinsheng Peng,2 Yitao Wang11State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China; 2School of Pharmaceutical Sciences, Guangdong Medical College, Dongguan, China&Dagger;These authors contributed equally to this workAbstract: Brucea javanica has demonstrated a variety of antitumoral, antimalarial, and anti-inflammatory properties. As a Chinese herbal medicine, Brucea javanica is mainly used in the treatment of lung and gastrointestinal cancers. Pharmacological research has identified the main antitumor components are tetracyclic triterpene quassinoids. However, most of these active components have poor water solubility and low bioavailability, which greatly limit their clinical application. Nanoparticulate delivery systems are urgently needed to improve the bioavailability of Brucea javanica. This paper mainly focuses on the chemical components in Brucea javanica and its pharmacological properties and nanoparticulate formulations, in an attempt to encourage further research on its active components and nanoparticulate drug delivery systems to expand its clinical applications. It is expected to improve the level of pharmaceutical research and provide a strong scientific foundation for further study on the medicinal properties of this plant.Keywords: Brucea javanica, chemical components, pharmacology, nanoparticulate delivery systems
format	article
author	Peng X Hu Y Tan W Wang S Chen R Chen M Wang Y
author_facet	Peng X Hu Y Tan W Wang S Chen R Chen M Wang Y
author_sort	Peng X
title	Chemical components, pharmacological properties, and nanoparticulate delivery systems of Brucea javanica
title_short	Chemical components, pharmacological properties, and nanoparticulate delivery systems of Brucea javanica
title_full	Chemical components, pharmacological properties, and nanoparticulate delivery systems of Brucea javanica
title_fullStr	Chemical components, pharmacological properties, and nanoparticulate delivery systems of Brucea javanica
title_full_unstemmed	Chemical components, pharmacological properties, and nanoparticulate delivery systems of Brucea javanica
title_sort	chemical components, pharmacological properties, and nanoparticulate delivery systems of brucea javanica
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/c02f4bbeceff41068b5003117056c0b8
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Chemical components, pharmacological properties, and nanoparticulate delivery systems of Brucea javanica

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