LncRNAs: Novel Biomarkers for Pancreatic Cancer

Pancreatic cancer is one of the most deadly neoplasms and the seventh major cause of cancer-related deaths among both males and females. This cancer has a poor prognosis due to the lack of appropriate methods for early detection of cancer. Long non-coding RNAs (lncRNAs) have been recently found to i...

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Autores principales:	Soudeh Ghafouri-Fard, Mohadeseh Fathi, Tianyue Zhai, Mohammad Taheri, Peixin Dong
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	lncRNAs pancreatic cancer biomarker diagnosis prognosis Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/c030a2d584344fca9982c981452118cc
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spelling	oai:doaj.org-article:c030a2d584344fca9982c981452118cc2021-11-25T16:53:32ZLncRNAs: Novel Biomarkers for Pancreatic Cancer10.3390/biom111116652218-273Xhttps://doaj.org/article/c030a2d584344fca9982c981452118cc2021-11-01T00:00:00Zhttps://www.mdpi.com/2218-273X/11/11/1665https://doaj.org/toc/2218-273XPancreatic cancer is one of the most deadly neoplasms and the seventh major cause of cancer-related deaths among both males and females. This cancer has a poor prognosis due to the lack of appropriate methods for early detection of cancer. Long non-coding RNAs (lncRNAs) have been recently found to influence the progression and initiation of pancreatic cancer. MACC1-AS1, LINC00976, LINC00462, LINC01559, HOXA-AS2, LINC00152, TP73-AS1, XIST, SNHG12, LUCAT1, and UCA1 are among the oncogenic lncRNAs in pancreatic cancer. On the other hand, LINC01111, LINC01963, DGCR5, MEG3, GAS5, and LINC00261 are among tumor suppressor lncRNAs in this tissue. In the current review, we summarize the roles of these two classes of lncRNAs in pancreatic cancer and discuss their potential as attractive diagnostic and prognostic biomarkers for pancreatic cancer. We also identified that the low expression of MEG3, LINC01963, and LINC00261 and the high expression of MACC1-AS1, LINC00462, LINC01559, and UCA1 were significantly correlated with worse survival in pancreatic cancer patients. Further research on these lncRNAs will provide new clues that could potentially improve the early diagnosis, prognostic prediction, and personalized treatments of patients with pancreatic cancer.Soudeh Ghafouri-FardMohadeseh FathiTianyue ZhaiMohammad TaheriPeixin DongMDPI AGarticlelncRNAspancreatic cancerbiomarkerdiagnosisprognosisMicrobiologyQR1-502ENBiomolecules, Vol 11, Iss 1665, p 1665 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	lncRNAs pancreatic cancer biomarker diagnosis prognosis Microbiology QR1-502
spellingShingle	lncRNAs pancreatic cancer biomarker diagnosis prognosis Microbiology QR1-502 Soudeh Ghafouri-Fard Mohadeseh Fathi Tianyue Zhai Mohammad Taheri Peixin Dong LncRNAs: Novel Biomarkers for Pancreatic Cancer
description	Pancreatic cancer is one of the most deadly neoplasms and the seventh major cause of cancer-related deaths among both males and females. This cancer has a poor prognosis due to the lack of appropriate methods for early detection of cancer. Long non-coding RNAs (lncRNAs) have been recently found to influence the progression and initiation of pancreatic cancer. MACC1-AS1, LINC00976, LINC00462, LINC01559, HOXA-AS2, LINC00152, TP73-AS1, XIST, SNHG12, LUCAT1, and UCA1 are among the oncogenic lncRNAs in pancreatic cancer. On the other hand, LINC01111, LINC01963, DGCR5, MEG3, GAS5, and LINC00261 are among tumor suppressor lncRNAs in this tissue. In the current review, we summarize the roles of these two classes of lncRNAs in pancreatic cancer and discuss their potential as attractive diagnostic and prognostic biomarkers for pancreatic cancer. We also identified that the low expression of MEG3, LINC01963, and LINC00261 and the high expression of MACC1-AS1, LINC00462, LINC01559, and UCA1 were significantly correlated with worse survival in pancreatic cancer patients. Further research on these lncRNAs will provide new clues that could potentially improve the early diagnosis, prognostic prediction, and personalized treatments of patients with pancreatic cancer.
format	article
author	Soudeh Ghafouri-Fard Mohadeseh Fathi Tianyue Zhai Mohammad Taheri Peixin Dong
author_facet	Soudeh Ghafouri-Fard Mohadeseh Fathi Tianyue Zhai Mohammad Taheri Peixin Dong
author_sort	Soudeh Ghafouri-Fard
title	LncRNAs: Novel Biomarkers for Pancreatic Cancer
title_short	LncRNAs: Novel Biomarkers for Pancreatic Cancer
title_full	LncRNAs: Novel Biomarkers for Pancreatic Cancer
title_fullStr	LncRNAs: Novel Biomarkers for Pancreatic Cancer
title_full_unstemmed	LncRNAs: Novel Biomarkers for Pancreatic Cancer
title_sort	lncrnas: novel biomarkers for pancreatic cancer
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c030a2d584344fca9982c981452118cc
work_keys_str_mv	AT soudehghafourifard lncrnasnovelbiomarkersforpancreaticcancer AT mohadesehfathi lncrnasnovelbiomarkersforpancreaticcancer AT tianyuezhai lncrnasnovelbiomarkersforpancreaticcancer AT mohammadtaheri lncrnasnovelbiomarkersforpancreaticcancer AT peixindong lncrnasnovelbiomarkersforpancreaticcancer
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LncRNAs: Novel Biomarkers for Pancreatic Cancer

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