N-terminal tyrosine of ISCU2 triggers [2Fe-2S] cluster synthesis by ISCU2 dimerization

[2Fe-2S] protein cofactors are essential for life and are synthesized on ISCU2 scaffolds. Here, the authors show that hydrophobic interaction of two conserved N-terminal tyrosines induces ISCU2 dimerization and concomitant [2Fe-2S] cluster synthesis.

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Autores principales:	Sven-A. Freibert, Michal T. Boniecki, Claudia Stümpfig, Vinzent Schulz, Nils Krapoth, Dennis R. Winge, Ulrich Mühlenhoff, Oliver Stehling, Miroslaw Cygler, Roland Lill
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c031fda3199f4ae4ade00e57b4490d02
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spelling	oai:doaj.org-article:c031fda3199f4ae4ade00e57b4490d022021-11-28T12:32:04ZN-terminal tyrosine of ISCU2 triggers [2Fe-2S] cluster synthesis by ISCU2 dimerization10.1038/s41467-021-27122-w2041-1723https://doaj.org/article/c031fda3199f4ae4ade00e57b4490d022021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27122-whttps://doaj.org/toc/2041-1723[2Fe-2S] protein cofactors are essential for life and are synthesized on ISCU2 scaffolds. Here, the authors show that hydrophobic interaction of two conserved N-terminal tyrosines induces ISCU2 dimerization and concomitant [2Fe-2S] cluster synthesis.Sven-A. FreibertMichal T. BonieckiClaudia StümpfigVinzent SchulzNils KrapothDennis R. WingeUlrich MühlenhoffOliver StehlingMiroslaw CyglerRoland LillNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sven-A. Freibert Michal T. Boniecki Claudia Stümpfig Vinzent Schulz Nils Krapoth Dennis R. Winge Ulrich Mühlenhoff Oliver Stehling Miroslaw Cygler Roland Lill N-terminal tyrosine of ISCU2 triggers [2Fe-2S] cluster synthesis by ISCU2 dimerization
description	[2Fe-2S] protein cofactors are essential for life and are synthesized on ISCU2 scaffolds. Here, the authors show that hydrophobic interaction of two conserved N-terminal tyrosines induces ISCU2 dimerization and concomitant [2Fe-2S] cluster synthesis.
format	article
author	Sven-A. Freibert Michal T. Boniecki Claudia Stümpfig Vinzent Schulz Nils Krapoth Dennis R. Winge Ulrich Mühlenhoff Oliver Stehling Miroslaw Cygler Roland Lill
author_facet	Sven-A. Freibert Michal T. Boniecki Claudia Stümpfig Vinzent Schulz Nils Krapoth Dennis R. Winge Ulrich Mühlenhoff Oliver Stehling Miroslaw Cygler Roland Lill
author_sort	Sven-A. Freibert
title	N-terminal tyrosine of ISCU2 triggers [2Fe-2S] cluster synthesis by ISCU2 dimerization
title_short	N-terminal tyrosine of ISCU2 triggers [2Fe-2S] cluster synthesis by ISCU2 dimerization
title_full	N-terminal tyrosine of ISCU2 triggers [2Fe-2S] cluster synthesis by ISCU2 dimerization
title_fullStr	N-terminal tyrosine of ISCU2 triggers [2Fe-2S] cluster synthesis by ISCU2 dimerization
title_full_unstemmed	N-terminal tyrosine of ISCU2 triggers [2Fe-2S] cluster synthesis by ISCU2 dimerization
title_sort	n-terminal tyrosine of iscu2 triggers [2fe-2s] cluster synthesis by iscu2 dimerization
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c031fda3199f4ae4ade00e57b4490d02
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N-terminal tyrosine of ISCU2 triggers [2Fe-2S] cluster synthesis by ISCU2 dimerization

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