Preliminary Safety and Efficacy of Proton Plus Carbon-Ion Radiotherapy With Concurrent Chemotherapy in Limited-Stage Small Cell Lung Cancer

ObjectivesThis study aimed to investigate the tolerance and effect of proton plus carbon-ion radiotherapy with concurrent chemotherapy in limited-stage small cell lung cancer using the pencil beam scanning technique.Materials and MethodsFrom March 2017 to April 2020, 25 patients with limited-stage s...

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Autores principales:	Ning-Yi Ma, Jian Chen, Xue Ming, Guo-Liang Jiang, Jiade J. Lu, Kai-Liang Wu, Jingfang Mao
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	small cell lung cancer radiotherapy proton carbon ion efficacy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/c03210bdedfd48e7b9eb50e667be599a
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spelling	oai:doaj.org-article:c03210bdedfd48e7b9eb50e667be599a2021-11-11T04:52:17ZPreliminary Safety and Efficacy of Proton Plus Carbon-Ion Radiotherapy With Concurrent Chemotherapy in Limited-Stage Small Cell Lung Cancer2234-943X10.3389/fonc.2021.766822https://doaj.org/article/c03210bdedfd48e7b9eb50e667be599a2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.766822/fullhttps://doaj.org/toc/2234-943XObjectivesThis study aimed to investigate the tolerance and effect of proton plus carbon-ion radiotherapy with concurrent chemotherapy in limited-stage small cell lung cancer using the pencil beam scanning technique.Materials and MethodsFrom March 2017 to April 2020, 25 patients with limited-stage small cell lung cancer treated with combined proton and carbon-ion radiotherapy were analyzed. The primary lesions and involved lymph nodes were irradiated using 2–4 portals. Proton and sequential carbon-ion beams were delivered with a median dose of 67.1 (range, 63–74.8) GyE as fraction doses of 2.0–2.2 GyE with proton beams in 20–23 fractions and 3.0–3.8 GyE with carbon ions in 5–8 fractions. Chemotherapy was delivered concurrently with radiotherapy in all patients.ResultsAt the last follow-up, the 2-year overall and locoregional progression-free survival rates were 81.7% and 66.7%, respectively. Radiochemotherapy was well tolerated, with grade 1, 2, and 3 acute toxicities occurring in 12.0%, 68.0%, and 20.0% of patients, respectively. All grade 3 acute toxicities were hematologically related changes. One patient experienced grade 3 acute non-hematological toxicity in the esophagus, and one other patient had grade 3 bronchial obstruction accompanied by obstructive atelectasis as a late side effect.ConclusionProton plus carbon-ion radiotherapy using pencil beam scanning yielded promising survival rates and tolerability in patients with limited-stage small cell lung cancer. A prospective clinical study is warranted to validate the therapeutic efficacy of particle radiotherapy in combination with chemotherapy in limited-stage small cell lung cancer.Ning-Yi MaNing-Yi MaNing-Yi MaJian ChenJian ChenJian ChenXue MingXue MingXue MingGuo-Liang JiangGuo-Liang JiangGuo-Liang JiangJiade J. LuJiade J. LuJiade J. LuKai-Liang WuKai-Liang WuKai-Liang WuJingfang MaoJingfang MaoJingfang MaoFrontiers Media S.A.articlesmall cell lung cancerradiotherapyprotoncarbon ionefficacyNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	small cell lung cancer radiotherapy proton carbon ion efficacy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	small cell lung cancer radiotherapy proton carbon ion efficacy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Ning-Yi Ma Ning-Yi Ma Ning-Yi Ma Jian Chen Jian Chen Jian Chen Xue Ming Xue Ming Xue Ming Guo-Liang Jiang Guo-Liang Jiang Guo-Liang Jiang Jiade J. Lu Jiade J. Lu Jiade J. Lu Kai-Liang Wu Kai-Liang Wu Kai-Liang Wu Jingfang Mao Jingfang Mao Jingfang Mao Preliminary Safety and Efficacy of Proton Plus Carbon-Ion Radiotherapy With Concurrent Chemotherapy in Limited-Stage Small Cell Lung Cancer
description	ObjectivesThis study aimed to investigate the tolerance and effect of proton plus carbon-ion radiotherapy with concurrent chemotherapy in limited-stage small cell lung cancer using the pencil beam scanning technique.Materials and MethodsFrom March 2017 to April 2020, 25 patients with limited-stage small cell lung cancer treated with combined proton and carbon-ion radiotherapy were analyzed. The primary lesions and involved lymph nodes were irradiated using 2–4 portals. Proton and sequential carbon-ion beams were delivered with a median dose of 67.1 (range, 63–74.8) GyE as fraction doses of 2.0–2.2 GyE with proton beams in 20–23 fractions and 3.0–3.8 GyE with carbon ions in 5–8 fractions. Chemotherapy was delivered concurrently with radiotherapy in all patients.ResultsAt the last follow-up, the 2-year overall and locoregional progression-free survival rates were 81.7% and 66.7%, respectively. Radiochemotherapy was well tolerated, with grade 1, 2, and 3 acute toxicities occurring in 12.0%, 68.0%, and 20.0% of patients, respectively. All grade 3 acute toxicities were hematologically related changes. One patient experienced grade 3 acute non-hematological toxicity in the esophagus, and one other patient had grade 3 bronchial obstruction accompanied by obstructive atelectasis as a late side effect.ConclusionProton plus carbon-ion radiotherapy using pencil beam scanning yielded promising survival rates and tolerability in patients with limited-stage small cell lung cancer. A prospective clinical study is warranted to validate the therapeutic efficacy of particle radiotherapy in combination with chemotherapy in limited-stage small cell lung cancer.
format	article
author	Ning-Yi Ma Ning-Yi Ma Ning-Yi Ma Jian Chen Jian Chen Jian Chen Xue Ming Xue Ming Xue Ming Guo-Liang Jiang Guo-Liang Jiang Guo-Liang Jiang Jiade J. Lu Jiade J. Lu Jiade J. Lu Kai-Liang Wu Kai-Liang Wu Kai-Liang Wu Jingfang Mao Jingfang Mao Jingfang Mao
author_facet	Ning-Yi Ma Ning-Yi Ma Ning-Yi Ma Jian Chen Jian Chen Jian Chen Xue Ming Xue Ming Xue Ming Guo-Liang Jiang Guo-Liang Jiang Guo-Liang Jiang Jiade J. Lu Jiade J. Lu Jiade J. Lu Kai-Liang Wu Kai-Liang Wu Kai-Liang Wu Jingfang Mao Jingfang Mao Jingfang Mao
author_sort	Ning-Yi Ma
title	Preliminary Safety and Efficacy of Proton Plus Carbon-Ion Radiotherapy With Concurrent Chemotherapy in Limited-Stage Small Cell Lung Cancer
title_short	Preliminary Safety and Efficacy of Proton Plus Carbon-Ion Radiotherapy With Concurrent Chemotherapy in Limited-Stage Small Cell Lung Cancer
title_full	Preliminary Safety and Efficacy of Proton Plus Carbon-Ion Radiotherapy With Concurrent Chemotherapy in Limited-Stage Small Cell Lung Cancer
title_fullStr	Preliminary Safety and Efficacy of Proton Plus Carbon-Ion Radiotherapy With Concurrent Chemotherapy in Limited-Stage Small Cell Lung Cancer
title_full_unstemmed	Preliminary Safety and Efficacy of Proton Plus Carbon-Ion Radiotherapy With Concurrent Chemotherapy in Limited-Stage Small Cell Lung Cancer
title_sort	preliminary safety and efficacy of proton plus carbon-ion radiotherapy with concurrent chemotherapy in limited-stage small cell lung cancer
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/c03210bdedfd48e7b9eb50e667be599a
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Preliminary Safety and Efficacy of Proton Plus Carbon-Ion Radiotherapy With Concurrent Chemotherapy in Limited-Stage Small Cell Lung Cancer

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