Notch transactivates Rheb to maintain the multipotency of TSC-null cells

Tuberous sclerosis complex (TSC) is a rare genetic condition causing tumours with differentiation abnormalities; however the molecular mechanisms causing these defects are unclear. Here the authors show that Notch cooperates with Rheb to block cell differentiation forming a regulatory loop that coul...

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Main Authors:	Jun-Hung Cho, Bhaumik Patel, Santosh Bonala, Sasikanth Manne, Yan Zhou, Surya K. Vadrevu, Jalpa Patel, Marco Peronaci, Shanawaz Ghouse, Elizabeth P. Henske, Fabrice Roegiers, Krinio Giannikou, David J. Kwiatkowski, Hossein Mansouri, Maciej M. Markiewski, Brandon White, Magdalena Karbowniczek
Format:	article
Language:	EN
Published:	Nature Portfolio 2017
Subjects:	Science Q
Online Access:	https://doaj.org/article/c032945d8d7b42608e09e9eacf6389a4
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spelling	oai:doaj.org-article:c032945d8d7b42608e09e9eacf6389a42021-12-02T14:41:22ZNotch transactivates Rheb to maintain the multipotency of TSC-null cells10.1038/s41467-017-01845-12041-1723https://doaj.org/article/c032945d8d7b42608e09e9eacf6389a42017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01845-1https://doaj.org/toc/2041-1723Tuberous sclerosis complex (TSC) is a rare genetic condition causing tumours with differentiation abnormalities; however the molecular mechanisms causing these defects are unclear. Here the authors show that Notch cooperates with Rheb to block cell differentiation forming a regulatory loop that could underlie TSC tumorigenesis.Jun-Hung ChoBhaumik PatelSantosh BonalaSasikanth ManneYan ZhouSurya K. VadrevuJalpa PatelMarco PeronaciShanawaz GhouseElizabeth P. HenskeFabrice RoegiersKrinio GiannikouDavid J. KwiatkowskiHossein MansouriMaciej M. MarkiewskiBrandon WhiteMagdalena KarbowniczekNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jun-Hung Cho Bhaumik Patel Santosh Bonala Sasikanth Manne Yan Zhou Surya K. Vadrevu Jalpa Patel Marco Peronaci Shanawaz Ghouse Elizabeth P. Henske Fabrice Roegiers Krinio Giannikou David J. Kwiatkowski Hossein Mansouri Maciej M. Markiewski Brandon White Magdalena Karbowniczek Notch transactivates Rheb to maintain the multipotency of TSC-null cells
description	Tuberous sclerosis complex (TSC) is a rare genetic condition causing tumours with differentiation abnormalities; however the molecular mechanisms causing these defects are unclear. Here the authors show that Notch cooperates with Rheb to block cell differentiation forming a regulatory loop that could underlie TSC tumorigenesis.
format	article
author	Jun-Hung Cho Bhaumik Patel Santosh Bonala Sasikanth Manne Yan Zhou Surya K. Vadrevu Jalpa Patel Marco Peronaci Shanawaz Ghouse Elizabeth P. Henske Fabrice Roegiers Krinio Giannikou David J. Kwiatkowski Hossein Mansouri Maciej M. Markiewski Brandon White Magdalena Karbowniczek
author_facet	Jun-Hung Cho Bhaumik Patel Santosh Bonala Sasikanth Manne Yan Zhou Surya K. Vadrevu Jalpa Patel Marco Peronaci Shanawaz Ghouse Elizabeth P. Henske Fabrice Roegiers Krinio Giannikou David J. Kwiatkowski Hossein Mansouri Maciej M. Markiewski Brandon White Magdalena Karbowniczek
author_sort	Jun-Hung Cho
title	Notch transactivates Rheb to maintain the multipotency of TSC-null cells
title_short	Notch transactivates Rheb to maintain the multipotency of TSC-null cells
title_full	Notch transactivates Rheb to maintain the multipotency of TSC-null cells
title_fullStr	Notch transactivates Rheb to maintain the multipotency of TSC-null cells
title_full_unstemmed	Notch transactivates Rheb to maintain the multipotency of TSC-null cells
title_sort	notch transactivates rheb to maintain the multipotency of tsc-null cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c032945d8d7b42608e09e9eacf6389a4
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Notch transactivates Rheb to maintain the multipotency of TSC-null cells

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