Advancements in the Pharmaceutical Applications of Probiotics: Dosage Forms and Formulation Technology

Kshitis Chandra Baral, Rajiv Bajracharya, Sang Hoon Lee, Hyo-Kyung Han BK21 FOUR Team and Integrated Research Institute for Drug Development, College of Pharmacy, Dongguk University-Seoul, Goyang, 10326, KoreaCorrespondence: Hyo-Kyung HanBK21 FOUR Team, College of Pharmacy, Dongguk University-Seoul,...

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Autores principales:	Baral KC, Bajracharya R, Lee SH, Han HK
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	probiotic therapeutic adjuvant formulation drug delivery system gut microbiota Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/c0337f7f6bd14c93b409b430089ba666
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spelling	oai:doaj.org-article:c0337f7f6bd14c93b409b430089ba6662021-12-02T18:16:54ZAdvancements in the Pharmaceutical Applications of Probiotics: Dosage Forms and Formulation Technology1178-2013https://doaj.org/article/c0337f7f6bd14c93b409b430089ba6662021-11-01T00:00:00Zhttps://www.dovepress.com/advancements-in-the-pharmaceutical-applications-of-probiotics-dosage-f-peer-reviewed-fulltext-article-IJNhttps://doaj.org/toc/1178-2013Kshitis Chandra Baral, Rajiv Bajracharya, Sang Hoon Lee, Hyo-Kyung Han BK21 FOUR Team and Integrated Research Institute for Drug Development, College of Pharmacy, Dongguk University-Seoul, Goyang, 10326, KoreaCorrespondence: Hyo-Kyung HanBK21 FOUR Team, College of Pharmacy, Dongguk University-Seoul, Dongguk-ro-32, Ilsan-Donggu, Goyang, 10326, KoreaTel +82-31-961-5217Fax +82-31-961-5206Email hkhan@dongguk.eduAbstract: Probiotics have demonstrated their high potential to treat and/or prevent various diseases including neurodegenerative disorders, cancers, cardiovascular diseases, and inflammatory diseases. Probiotics are also effective against multidrug-resistant pathogens and help maintain a balanced gut microbiota ecosystem. Accordingly, the global market of probiotics is growing rapidly, and research efforts to develop probiotics into therapeutic adjuvants are gaining momentum. However, because probiotics are living microorganisms, many biological and biopharmaceutical barriers limit their clinical application. Probiotics may lose their activity in the harsh gastric conditions of the stomach or in the presence of bile salts. Moreover, they easily lose their viability under thermal or oxidative stress during their preparation and storage. Therefore, stable formulations of probiotics are required to overcome the various physicochemical, biopharmaceutical, and biological barriers and to maximize their therapeutic effectiveness and clinical applicability. This review provides an overview of the pharmaceutical applications of probiotics and covers recent formulation approaches to optimize the delivery of probiotics with particular emphasis on various dosage forms and formulation technologies.Keywords: probiotic, therapeutic adjuvant, formulation, drug delivery system, gut microbiotaBaral KCBajracharya RLee SHHan HKDove Medical Pressarticleprobiotictherapeutic adjuvantformulationdrug delivery systemgut microbiotaMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 16, Pp 7535-7556 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	probiotic therapeutic adjuvant formulation drug delivery system gut microbiota Medicine (General) R5-920
spellingShingle	probiotic therapeutic adjuvant formulation drug delivery system gut microbiota Medicine (General) R5-920 Baral KC Bajracharya R Lee SH Han HK Advancements in the Pharmaceutical Applications of Probiotics: Dosage Forms and Formulation Technology
description	Kshitis Chandra Baral, Rajiv Bajracharya, Sang Hoon Lee, Hyo-Kyung Han BK21 FOUR Team and Integrated Research Institute for Drug Development, College of Pharmacy, Dongguk University-Seoul, Goyang, 10326, KoreaCorrespondence: Hyo-Kyung HanBK21 FOUR Team, College of Pharmacy, Dongguk University-Seoul, Dongguk-ro-32, Ilsan-Donggu, Goyang, 10326, KoreaTel +82-31-961-5217Fax +82-31-961-5206Email hkhan@dongguk.eduAbstract: Probiotics have demonstrated their high potential to treat and/or prevent various diseases including neurodegenerative disorders, cancers, cardiovascular diseases, and inflammatory diseases. Probiotics are also effective against multidrug-resistant pathogens and help maintain a balanced gut microbiota ecosystem. Accordingly, the global market of probiotics is growing rapidly, and research efforts to develop probiotics into therapeutic adjuvants are gaining momentum. However, because probiotics are living microorganisms, many biological and biopharmaceutical barriers limit their clinical application. Probiotics may lose their activity in the harsh gastric conditions of the stomach or in the presence of bile salts. Moreover, they easily lose their viability under thermal or oxidative stress during their preparation and storage. Therefore, stable formulations of probiotics are required to overcome the various physicochemical, biopharmaceutical, and biological barriers and to maximize their therapeutic effectiveness and clinical applicability. This review provides an overview of the pharmaceutical applications of probiotics and covers recent formulation approaches to optimize the delivery of probiotics with particular emphasis on various dosage forms and formulation technologies.Keywords: probiotic, therapeutic adjuvant, formulation, drug delivery system, gut microbiota
format	article
author	Baral KC Bajracharya R Lee SH Han HK
author_facet	Baral KC Bajracharya R Lee SH Han HK
author_sort	Baral KC
title	Advancements in the Pharmaceutical Applications of Probiotics: Dosage Forms and Formulation Technology
title_short	Advancements in the Pharmaceutical Applications of Probiotics: Dosage Forms and Formulation Technology
title_full	Advancements in the Pharmaceutical Applications of Probiotics: Dosage Forms and Formulation Technology
title_fullStr	Advancements in the Pharmaceutical Applications of Probiotics: Dosage Forms and Formulation Technology
title_full_unstemmed	Advancements in the Pharmaceutical Applications of Probiotics: Dosage Forms and Formulation Technology
title_sort	advancements in the pharmaceutical applications of probiotics: dosage forms and formulation technology
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/c0337f7f6bd14c93b409b430089ba666
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Advancements in the Pharmaceutical Applications of Probiotics: Dosage Forms and Formulation Technology

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