Anterior thalamic nuclei neurons sustain memory

A hippocampal-diencephalic-cortical network supports memory function. The anterior thalamic nuclei (ATN) form a key anatomical hub within this system. Consistent with this, injury to the mammillary body-ATN axis is associated with examples of clinical amnesia. However, there is only limited and indi...

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Autores principales:	S.C. Barnett, L.C. Parr-Brownlie, B.A.L. Perry, C.K. Young, H.E. Wicky, S.M. Hughes, N. McNaughton, J.C. Dalrymple-Alford
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Anterior thalamic nuclei Mammillothalamc tract Lesions Optogenetics Spatial memory Recovery of function Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/c034fe75b24c4e6d8476d1419874bedb
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spelling	oai:doaj.org-article:c034fe75b24c4e6d8476d1419874bedb2021-11-04T04:39:29ZAnterior thalamic nuclei neurons sustain memory2665-945X10.1016/j.crneur.2021.100022https://doaj.org/article/c034fe75b24c4e6d8476d1419874bedb2021-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2665945X21000188https://doaj.org/toc/2665-945XA hippocampal-diencephalic-cortical network supports memory function. The anterior thalamic nuclei (ATN) form a key anatomical hub within this system. Consistent with this, injury to the mammillary body-ATN axis is associated with examples of clinical amnesia. However, there is only limited and indirect support that the output of ATN neurons actively enhances memory. Here, in rats, we first showed that mammillothalamic tract (MTT) lesions caused a persistent impairment in spatial working memory. MTT lesions also reduced rhythmic electrical activity across the memory system. Next, we introduced 8.5 Hz optogenetic theta-burst stimulation of the ATN glutamatergic neurons. The exogenously-triggered, regular pattern of stimulation produced an acute and substantial improvement of spatial working memory in rats with MTT lesions and enhanced rhythmic electrical activity. Neither behaviour nor rhythmic activity was affected by endogenous stimulation derived from the dorsal hippocampus. Analysis of immediate early gene activity, after the rats foraged for food in an open field, showed that exogenously-triggered ATN stimulation also increased Zif268 expression across memory-related structures. These findings provide clear evidence that increased ATN neuronal activity supports memory. They suggest that ATN-focused gene therapy may be feasible to counter clinical amnesia associated with dysfunction in the mammillary body-ATN axis.S.C. BarnettL.C. Parr-BrownlieB.A.L. PerryC.K. YoungH.E. WickyS.M. HughesN. McNaughtonJ.C. Dalrymple-AlfordElsevierarticleAnterior thalamic nucleiMammillothalamc tractLesionsOptogeneticsSpatial memoryRecovery of functionNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENCurrent Research in Neurobiology, Vol 2, Iss , Pp 100022- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Anterior thalamic nuclei Mammillothalamc tract Lesions Optogenetics Spatial memory Recovery of function Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Anterior thalamic nuclei Mammillothalamc tract Lesions Optogenetics Spatial memory Recovery of function Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 S.C. Barnett L.C. Parr-Brownlie B.A.L. Perry C.K. Young H.E. Wicky S.M. Hughes N. McNaughton J.C. Dalrymple-Alford Anterior thalamic nuclei neurons sustain memory
description	A hippocampal-diencephalic-cortical network supports memory function. The anterior thalamic nuclei (ATN) form a key anatomical hub within this system. Consistent with this, injury to the mammillary body-ATN axis is associated with examples of clinical amnesia. However, there is only limited and indirect support that the output of ATN neurons actively enhances memory. Here, in rats, we first showed that mammillothalamic tract (MTT) lesions caused a persistent impairment in spatial working memory. MTT lesions also reduced rhythmic electrical activity across the memory system. Next, we introduced 8.5 Hz optogenetic theta-burst stimulation of the ATN glutamatergic neurons. The exogenously-triggered, regular pattern of stimulation produced an acute and substantial improvement of spatial working memory in rats with MTT lesions and enhanced rhythmic electrical activity. Neither behaviour nor rhythmic activity was affected by endogenous stimulation derived from the dorsal hippocampus. Analysis of immediate early gene activity, after the rats foraged for food in an open field, showed that exogenously-triggered ATN stimulation also increased Zif268 expression across memory-related structures. These findings provide clear evidence that increased ATN neuronal activity supports memory. They suggest that ATN-focused gene therapy may be feasible to counter clinical amnesia associated with dysfunction in the mammillary body-ATN axis.
format	article
author	S.C. Barnett L.C. Parr-Brownlie B.A.L. Perry C.K. Young H.E. Wicky S.M. Hughes N. McNaughton J.C. Dalrymple-Alford
author_facet	S.C. Barnett L.C. Parr-Brownlie B.A.L. Perry C.K. Young H.E. Wicky S.M. Hughes N. McNaughton J.C. Dalrymple-Alford
author_sort	S.C. Barnett
title	Anterior thalamic nuclei neurons sustain memory
title_short	Anterior thalamic nuclei neurons sustain memory
title_full	Anterior thalamic nuclei neurons sustain memory
title_fullStr	Anterior thalamic nuclei neurons sustain memory
title_full_unstemmed	Anterior thalamic nuclei neurons sustain memory
title_sort	anterior thalamic nuclei neurons sustain memory
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/c034fe75b24c4e6d8476d1419874bedb
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_version_	1718445237094842368

Anterior thalamic nuclei neurons sustain memory

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