Effects of bed-rest on urea and creatinine: correlation with changes in fat-free mass.

<h4>Background</h4>Bed-rest experiments are designed for investigation on catabolic effects of hypokinetic conditions and/or for microgravity simulation in on-ground aerospace research. Bed-rest effects include a reduction in fat-free mass and muscle mass. Urea and creatinine are catabol...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Giancarlo Bilancio, Cinzia Lombardi, Rado Pisot, Natale G De Santo, Pierpaolo Cavallo, Massimo Cirillo
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c0383d27aa1748728a2ef9dce9dd8ebf
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c0383d27aa1748728a2ef9dce9dd8ebf
record_format	dspace
spelling	oai:doaj.org-article:c0383d27aa1748728a2ef9dce9dd8ebf2021-11-25T05:58:53ZEffects of bed-rest on urea and creatinine: correlation with changes in fat-free mass.1932-620310.1371/journal.pone.0108805https://doaj.org/article/c0383d27aa1748728a2ef9dce9dd8ebf2014-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0108805https://doaj.org/toc/1932-6203<h4>Background</h4>Bed-rest experiments are designed for investigation on catabolic effects of hypokinetic conditions and/or for microgravity simulation in on-ground aerospace research. Bed-rest effects include a reduction in fat-free mass and muscle mass. Urea and creatinine are catabolites of endogenous protein and of muscular energetic metabolism which are excreted mainly by the kidney. The study investigated on urea, creatinine, and kidney function during bed-rest.<h4>Methods</h4>Twenty healthy young men underwent a 7-day adaptation period (day-6 to day-0) and a 35-day bed-rest experiment (day1 to day35) during normocaloric diet. Urine were collected from day-3 to day0 (baseline) and from day1 to day35. Blood samples and anthropometrical data were collected at day0 (baseline) and bed-rest days 7, 14, 21, 28, and 35.<h4>Results</h4>Bed-rest reduced plasma volume, weight, fat-free mass, and muscle mass (P<0.001). During bed-rest there was a transient increase in plasma and urinary urea, a decrease in plasma creatinine, and no change in urinary creatinine. The overall integral of changes from day0 to day35 was on average +101.7 mg/dL for plasma urea (95%CI = +43.4/+159.9), +82.2 g/24 h for urinary urea (95%CI = +55.8/+108.7), -2.5 mg/dL for plasma creatinine (95%CI = -3.1/-1.9). Bed-rest reduced plasma cistatyn C also, which was used as mass-independent marker of glomerular filtration rate (-13.1%, P<0.05). Correlations with final reduction in fat-free mass and muscle mass were significant for the overall integral of changes in urinary urea from day0 to day35 (R = 0.706, P<0.001) and for early changes in urinary urea and plasma urea from day0 to day7 (R = 0.566, P = 0.009 and R = 0.715, P<0.001, respectively).<h4>Conclusions</h4>Study results shows that urea is a marker of catabolic conditions secondary to hypokinetic conditions.Giancarlo BilancioCinzia LombardiRado PisotNatale G De SantoPierpaolo CavalloMassimo CirilloPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 9, p e108805 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Giancarlo Bilancio Cinzia Lombardi Rado Pisot Natale G De Santo Pierpaolo Cavallo Massimo Cirillo Effects of bed-rest on urea and creatinine: correlation with changes in fat-free mass.
description	<h4>Background</h4>Bed-rest experiments are designed for investigation on catabolic effects of hypokinetic conditions and/or for microgravity simulation in on-ground aerospace research. Bed-rest effects include a reduction in fat-free mass and muscle mass. Urea and creatinine are catabolites of endogenous protein and of muscular energetic metabolism which are excreted mainly by the kidney. The study investigated on urea, creatinine, and kidney function during bed-rest.<h4>Methods</h4>Twenty healthy young men underwent a 7-day adaptation period (day-6 to day-0) and a 35-day bed-rest experiment (day1 to day35) during normocaloric diet. Urine were collected from day-3 to day0 (baseline) and from day1 to day35. Blood samples and anthropometrical data were collected at day0 (baseline) and bed-rest days 7, 14, 21, 28, and 35.<h4>Results</h4>Bed-rest reduced plasma volume, weight, fat-free mass, and muscle mass (P<0.001). During bed-rest there was a transient increase in plasma and urinary urea, a decrease in plasma creatinine, and no change in urinary creatinine. The overall integral of changes from day0 to day35 was on average +101.7 mg/dL for plasma urea (95%CI = +43.4/+159.9), +82.2 g/24 h for urinary urea (95%CI = +55.8/+108.7), -2.5 mg/dL for plasma creatinine (95%CI = -3.1/-1.9). Bed-rest reduced plasma cistatyn C also, which was used as mass-independent marker of glomerular filtration rate (-13.1%, P<0.05). Correlations with final reduction in fat-free mass and muscle mass were significant for the overall integral of changes in urinary urea from day0 to day35 (R = 0.706, P<0.001) and for early changes in urinary urea and plasma urea from day0 to day7 (R = 0.566, P = 0.009 and R = 0.715, P<0.001, respectively).<h4>Conclusions</h4>Study results shows that urea is a marker of catabolic conditions secondary to hypokinetic conditions.
format	article
author	Giancarlo Bilancio Cinzia Lombardi Rado Pisot Natale G De Santo Pierpaolo Cavallo Massimo Cirillo
author_facet	Giancarlo Bilancio Cinzia Lombardi Rado Pisot Natale G De Santo Pierpaolo Cavallo Massimo Cirillo
author_sort	Giancarlo Bilancio
title	Effects of bed-rest on urea and creatinine: correlation with changes in fat-free mass.
title_short	Effects of bed-rest on urea and creatinine: correlation with changes in fat-free mass.
title_full	Effects of bed-rest on urea and creatinine: correlation with changes in fat-free mass.
title_fullStr	Effects of bed-rest on urea and creatinine: correlation with changes in fat-free mass.
title_full_unstemmed	Effects of bed-rest on urea and creatinine: correlation with changes in fat-free mass.
title_sort	effects of bed-rest on urea and creatinine: correlation with changes in fat-free mass.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/c0383d27aa1748728a2ef9dce9dd8ebf
work_keys_str_mv	AT giancarlobilancio effectsofbedrestonureaandcreatininecorrelationwithchangesinfatfreemass AT cinzialombardi effectsofbedrestonureaandcreatininecorrelationwithchangesinfatfreemass AT radopisot effectsofbedrestonureaandcreatininecorrelationwithchangesinfatfreemass AT natalegdesanto effectsofbedrestonureaandcreatininecorrelationwithchangesinfatfreemass AT pierpaolocavallo effectsofbedrestonureaandcreatininecorrelationwithchangesinfatfreemass AT massimocirillo effectsofbedrestonureaandcreatininecorrelationwithchangesinfatfreemass
_version_	1718414365319757824

Effects of bed-rest on urea and creatinine: correlation with changes in fat-free mass.

Ejemplares similares