Gene expression associated with individual variability in intrinsic functional connectivity

It has been revealed that intersubject variability (ISV) in intrinsic functional connectivity (FC) is associated with a wide variety of cognitive and behavioral performances. However, the underlying organizational principle of ISV in FC and its related gene transcriptional profiles remain unclear. U...

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Autores principales:	Liangfang Li, Yongbin Wei, Jinbo Zhang, Junji Ma, Yangyang Yi, Yue Gu, Liman Man Wai Li, Ying Lin, Zhengjia Dai
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Intersubject variability Functional connectivity Resting-state fMRI Gene expression Metabolism Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/c038ef612baa4643a066afc68d11cefc
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spelling	oai:doaj.org-article:c038ef612baa4643a066afc68d11cefc2021-11-28T04:29:13ZGene expression associated with individual variability in intrinsic functional connectivity1095-957210.1016/j.neuroimage.2021.118743https://doaj.org/article/c038ef612baa4643a066afc68d11cefc2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1053811921010156https://doaj.org/toc/1095-9572It has been revealed that intersubject variability (ISV) in intrinsic functional connectivity (FC) is associated with a wide variety of cognitive and behavioral performances. However, the underlying organizational principle of ISV in FC and its related gene transcriptional profiles remain unclear. Using resting-state fMRI data from the Human Connectome Project (299 adult participants) and microarray gene expression data from the Allen Human Brain Atlas, we conducted a transcription-neuroimaging association study to investigate the spatial configurations of ISV in intrinsic FC and their associations with spatial gene transcriptional profiles. We found that the multimodal association cortices showed the greatest ISV in FC, while the unimodal cortices and subcortical areas showed the least ISV. Importantly, partial least squares regression analysis revealed that the transcriptional profiles of genes associated with human accelerated regions (HARs) could explain 31.29% of the variation in the spatial distribution of ISV in FC. The top-related genes in the transcriptional profiles were enriched for the development of the central nervous system, neurogenesis and the cellular components of synapse. Moreover, we observed that the effect of gene expression profile on the heterogeneous distribution of ISV in FC was significantly mediated by the cerebral blood flow configuration. These findings highlighted the spatial arrangement of ISV in FC and their coupling with variations in transcriptional profiles and cerebral blood flow supply.Liangfang LiYongbin WeiJinbo ZhangJunji MaYangyang YiYue GuLiman Man Wai LiYing LinZhengjia DaiElsevierarticleIntersubject variabilityFunctional connectivityResting-state fMRIGene expressionMetabolismNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENNeuroImage, Vol 245, Iss , Pp 118743- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Intersubject variability Functional connectivity Resting-state fMRI Gene expression Metabolism Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Intersubject variability Functional connectivity Resting-state fMRI Gene expression Metabolism Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Liangfang Li Yongbin Wei Jinbo Zhang Junji Ma Yangyang Yi Yue Gu Liman Man Wai Li Ying Lin Zhengjia Dai Gene expression associated with individual variability in intrinsic functional connectivity
description	It has been revealed that intersubject variability (ISV) in intrinsic functional connectivity (FC) is associated with a wide variety of cognitive and behavioral performances. However, the underlying organizational principle of ISV in FC and its related gene transcriptional profiles remain unclear. Using resting-state fMRI data from the Human Connectome Project (299 adult participants) and microarray gene expression data from the Allen Human Brain Atlas, we conducted a transcription-neuroimaging association study to investigate the spatial configurations of ISV in intrinsic FC and their associations with spatial gene transcriptional profiles. We found that the multimodal association cortices showed the greatest ISV in FC, while the unimodal cortices and subcortical areas showed the least ISV. Importantly, partial least squares regression analysis revealed that the transcriptional profiles of genes associated with human accelerated regions (HARs) could explain 31.29% of the variation in the spatial distribution of ISV in FC. The top-related genes in the transcriptional profiles were enriched for the development of the central nervous system, neurogenesis and the cellular components of synapse. Moreover, we observed that the effect of gene expression profile on the heterogeneous distribution of ISV in FC was significantly mediated by the cerebral blood flow configuration. These findings highlighted the spatial arrangement of ISV in FC and their coupling with variations in transcriptional profiles and cerebral blood flow supply.
format	article
author	Liangfang Li Yongbin Wei Jinbo Zhang Junji Ma Yangyang Yi Yue Gu Liman Man Wai Li Ying Lin Zhengjia Dai
author_facet	Liangfang Li Yongbin Wei Jinbo Zhang Junji Ma Yangyang Yi Yue Gu Liman Man Wai Li Ying Lin Zhengjia Dai
author_sort	Liangfang Li
title	Gene expression associated with individual variability in intrinsic functional connectivity
title_short	Gene expression associated with individual variability in intrinsic functional connectivity
title_full	Gene expression associated with individual variability in intrinsic functional connectivity
title_fullStr	Gene expression associated with individual variability in intrinsic functional connectivity
title_full_unstemmed	Gene expression associated with individual variability in intrinsic functional connectivity
title_sort	gene expression associated with individual variability in intrinsic functional connectivity
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/c038ef612baa4643a066afc68d11cefc
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_version_	1718408405723381760

Gene expression associated with individual variability in intrinsic functional connectivity

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