Participation of nitrogen oxide and its metabolites in the genesis of hyperimmune inflammation in COVID-19

Despite the success in the tactics of treating COVID-19, there are many unexplored issues related to the development and progression of the process in the lungs, brain, and other organs, as well as the role of individual elements, in particular, nitric oxide (NO), and in the pathogenesis of organ da...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sergey Petrovich Lysenkov, Dmitriy Vitalevich Muzhenya, Aminat Ramazanovna Tuguz, Tamara Ur′evna Urakova, Dmitriy Sergeevich Shumilov, Ibragim Askarbievich Thakushinov
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Medknow Publications 2021
Materias:	brain covid-19 lungs nitric oxide peroxynitrite vascular endothelium Physiology QP1-981
Acceso en línea:	https://doaj.org/article/c03b6d4e4b414893a77738568346604e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c03b6d4e4b414893a77738568346604e
record_format	dspace
spelling	oai:doaj.org-article:c03b6d4e4b414893a77738568346604e2021-11-12T10:09:38ZParticipation of nitrogen oxide and its metabolites in the genesis of hyperimmune inflammation in COVID-190304-49202666-005910.4103/cjp.cjp_38_21https://doaj.org/article/c03b6d4e4b414893a77738568346604e2021-01-01T00:00:00Zhttp://www.cjphysiology.org/article.asp?issn=0304-4920;year=2021;volume=64;issue=4;spage=167;epage=176;aulast=Lysenkovhttps://doaj.org/toc/0304-4920https://doaj.org/toc/2666-0059Despite the success in the tactics of treating COVID-19, there are many unexplored issues related to the development and progression of the process in the lungs, brain, and other organs, as well as the role of individual elements, in particular, nitric oxide (NO), and in the pathogenesis of organ damage. Based on the analyzed literature data, we considered a possible pathophysiological mechanism of action of NO and its derivatives in COVID-19. It can be noted that hyperimmune systemic inflammation and “cytokine storm” are enhanced by the production of NO, products of its oxidation (“nitrosative stress”). It is noted in the work that as a result of the oxidation of NO, a large amount of the toxic compound peroxynitrite is formed, which is a powerful proinflammatory agent. Its presence significantly damages the endothelium of the vascular walls and also oxidizes lipids, hemoglobin, myoglobin, and cytochrome, binds SH-groups of proteins, and damages DNA in the target cells. This is confirmed by the picture of the vessels of the lungs on computed tomography and the data of biochemical studies. In case of peroxynitrite overproduction, inhibition of the synthesis of NO and its metabolic products seems to be justified. Another aspect considered in this work is the mechanism of damage by the virus to the central and peripheral nervous system, which remains poorly understood but may be important in understanding the consequences, as well as predicting brain functions in persons who have undergone COVID-19. According to the analyzed literature, it can be concluded that brain damage is possible due to the direct effect of the virus on the peripheral nerves and central structures, and indirectly through the effect on the endothelium of cerebral vessels. Disturbances in the central nervous regulation of immune responses may be associated with the insufficient function of the acetylcholine anti-inflammatory system. It is proposed to further study several approaches to influence various links of NO exchange, which are of interest for theoretical and practical medicine.Sergey Petrovich LysenkovDmitriy Vitalevich MuzhenyaAminat Ramazanovna TuguzTamara Ur′evna UrakovaDmitriy Sergeevich ShumilovIbragim Askarbievich ThakushinovWolters Kluwer Medknow Publicationsarticlebraincovid-19lungsnitric oxideperoxynitritevascular endotheliumPhysiologyQP1-981ENChinese Journal of Physiology, Vol 64, Iss 4, Pp 167-176 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	brain covid-19 lungs nitric oxide peroxynitrite vascular endothelium Physiology QP1-981
spellingShingle	brain covid-19 lungs nitric oxide peroxynitrite vascular endothelium Physiology QP1-981 Sergey Petrovich Lysenkov Dmitriy Vitalevich Muzhenya Aminat Ramazanovna Tuguz Tamara Ur′evna Urakova Dmitriy Sergeevich Shumilov Ibragim Askarbievich Thakushinov Participation of nitrogen oxide and its metabolites in the genesis of hyperimmune inflammation in COVID-19
description	Despite the success in the tactics of treating COVID-19, there are many unexplored issues related to the development and progression of the process in the lungs, brain, and other organs, as well as the role of individual elements, in particular, nitric oxide (NO), and in the pathogenesis of organ damage. Based on the analyzed literature data, we considered a possible pathophysiological mechanism of action of NO and its derivatives in COVID-19. It can be noted that hyperimmune systemic inflammation and “cytokine storm” are enhanced by the production of NO, products of its oxidation (“nitrosative stress”). It is noted in the work that as a result of the oxidation of NO, a large amount of the toxic compound peroxynitrite is formed, which is a powerful proinflammatory agent. Its presence significantly damages the endothelium of the vascular walls and also oxidizes lipids, hemoglobin, myoglobin, and cytochrome, binds SH-groups of proteins, and damages DNA in the target cells. This is confirmed by the picture of the vessels of the lungs on computed tomography and the data of biochemical studies. In case of peroxynitrite overproduction, inhibition of the synthesis of NO and its metabolic products seems to be justified. Another aspect considered in this work is the mechanism of damage by the virus to the central and peripheral nervous system, which remains poorly understood but may be important in understanding the consequences, as well as predicting brain functions in persons who have undergone COVID-19. According to the analyzed literature, it can be concluded that brain damage is possible due to the direct effect of the virus on the peripheral nerves and central structures, and indirectly through the effect on the endothelium of cerebral vessels. Disturbances in the central nervous regulation of immune responses may be associated with the insufficient function of the acetylcholine anti-inflammatory system. It is proposed to further study several approaches to influence various links of NO exchange, which are of interest for theoretical and practical medicine.
format	article
author	Sergey Petrovich Lysenkov Dmitriy Vitalevich Muzhenya Aminat Ramazanovna Tuguz Tamara Ur′evna Urakova Dmitriy Sergeevich Shumilov Ibragim Askarbievich Thakushinov
author_facet	Sergey Petrovich Lysenkov Dmitriy Vitalevich Muzhenya Aminat Ramazanovna Tuguz Tamara Ur′evna Urakova Dmitriy Sergeevich Shumilov Ibragim Askarbievich Thakushinov
author_sort	Sergey Petrovich Lysenkov
title	Participation of nitrogen oxide and its metabolites in the genesis of hyperimmune inflammation in COVID-19
title_short	Participation of nitrogen oxide and its metabolites in the genesis of hyperimmune inflammation in COVID-19
title_full	Participation of nitrogen oxide and its metabolites in the genesis of hyperimmune inflammation in COVID-19
title_fullStr	Participation of nitrogen oxide and its metabolites in the genesis of hyperimmune inflammation in COVID-19
title_full_unstemmed	Participation of nitrogen oxide and its metabolites in the genesis of hyperimmune inflammation in COVID-19
title_sort	participation of nitrogen oxide and its metabolites in the genesis of hyperimmune inflammation in covid-19
publisher	Wolters Kluwer Medknow Publications
publishDate	2021
url	https://doaj.org/article/c03b6d4e4b414893a77738568346604e
work_keys_str_mv	AT sergeypetrovichlysenkov participationofnitrogenoxideanditsmetabolitesinthegenesisofhyperimmuneinflammationincovid19 AT dmitriyvitalevichmuzhenya participationofnitrogenoxideanditsmetabolitesinthegenesisofhyperimmuneinflammationincovid19 AT aminatramazanovnatuguz participationofnitrogenoxideanditsmetabolitesinthegenesisofhyperimmuneinflammationincovid19 AT tamaraurevnaurakova participationofnitrogenoxideanditsmetabolitesinthegenesisofhyperimmuneinflammationincovid19 AT dmitriysergeevichshumilov participationofnitrogenoxideanditsmetabolitesinthegenesisofhyperimmuneinflammationincovid19 AT ibragimaskarbievichthakushinov participationofnitrogenoxideanditsmetabolitesinthegenesisofhyperimmuneinflammationincovid19
_version_	1718431075635560448

Participation of nitrogen oxide and its metabolites in the genesis of hyperimmune inflammation in COVID-19

Ejemplares similares