LINC complex-Lis1 interplay controls MT1-MMP matrix digest-on-demand response for confined tumor cell migration

The ability of cancer cells to migrate through small, constricted areas is limited by nuclear stiffness. Here the authors show that in turn nuclear stiffness stimulates the delivery of enzymes important for the degradation of the extracellular matrix and the formation of invadopodia in association w...

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Autores principales:	Elvira Infante, Alessia Castagnino, Robin Ferrari, Pedro Monteiro, Sonia Agüera-González, Perrine Paul-Gilloteaux, Mélanie J. Domingues, Paolo Maiuri, Matthew Raab, Catherine M. Shanahan, Alexandre Baffet, Matthieu Piel, Edgar R. Gomes, Philippe Chavrier
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c03c4d3f6d774108a7eadc5798a2cc80
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spelling	oai:doaj.org-article:c03c4d3f6d774108a7eadc5798a2cc802021-12-02T17:33:18ZLINC complex-Lis1 interplay controls MT1-MMP matrix digest-on-demand response for confined tumor cell migration10.1038/s41467-018-04865-72041-1723https://doaj.org/article/c03c4d3f6d774108a7eadc5798a2cc802018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04865-7https://doaj.org/toc/2041-1723The ability of cancer cells to migrate through small, constricted areas is limited by nuclear stiffness. Here the authors show that in turn nuclear stiffness stimulates the delivery of enzymes important for the degradation of the extracellular matrix and the formation of invadopodia in association with fibers thus opposing nuclear movement.Elvira InfanteAlessia CastagninoRobin FerrariPedro MonteiroSonia Agüera-GonzálezPerrine Paul-GilloteauxMélanie J. DominguesPaolo MaiuriMatthew RaabCatherine M. ShanahanAlexandre BaffetMatthieu PielEdgar R. GomesPhilippe ChavrierNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Elvira Infante Alessia Castagnino Robin Ferrari Pedro Monteiro Sonia Agüera-González Perrine Paul-Gilloteaux Mélanie J. Domingues Paolo Maiuri Matthew Raab Catherine M. Shanahan Alexandre Baffet Matthieu Piel Edgar R. Gomes Philippe Chavrier LINC complex-Lis1 interplay controls MT1-MMP matrix digest-on-demand response for confined tumor cell migration
description	The ability of cancer cells to migrate through small, constricted areas is limited by nuclear stiffness. Here the authors show that in turn nuclear stiffness stimulates the delivery of enzymes important for the degradation of the extracellular matrix and the formation of invadopodia in association with fibers thus opposing nuclear movement.
format	article
author	Elvira Infante Alessia Castagnino Robin Ferrari Pedro Monteiro Sonia Agüera-González Perrine Paul-Gilloteaux Mélanie J. Domingues Paolo Maiuri Matthew Raab Catherine M. Shanahan Alexandre Baffet Matthieu Piel Edgar R. Gomes Philippe Chavrier
author_facet	Elvira Infante Alessia Castagnino Robin Ferrari Pedro Monteiro Sonia Agüera-González Perrine Paul-Gilloteaux Mélanie J. Domingues Paolo Maiuri Matthew Raab Catherine M. Shanahan Alexandre Baffet Matthieu Piel Edgar R. Gomes Philippe Chavrier
author_sort	Elvira Infante
title	LINC complex-Lis1 interplay controls MT1-MMP matrix digest-on-demand response for confined tumor cell migration
title_short	LINC complex-Lis1 interplay controls MT1-MMP matrix digest-on-demand response for confined tumor cell migration
title_full	LINC complex-Lis1 interplay controls MT1-MMP matrix digest-on-demand response for confined tumor cell migration
title_fullStr	LINC complex-Lis1 interplay controls MT1-MMP matrix digest-on-demand response for confined tumor cell migration
title_full_unstemmed	LINC complex-Lis1 interplay controls MT1-MMP matrix digest-on-demand response for confined tumor cell migration
title_sort	linc complex-lis1 interplay controls mt1-mmp matrix digest-on-demand response for confined tumor cell migration
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/c03c4d3f6d774108a7eadc5798a2cc80
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LINC complex-Lis1 interplay controls MT1-MMP matrix digest-on-demand response for confined tumor cell migration

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