Single Nucleotide Polymorphisms from <i>CSF2</i>, <i>FLT1</i>, <i>TFPI</i> and <i>TLR9</i> Genes Are Associated with Prelabor Rupture of Membranes
A prelabor rupture of membranes (PROM) and its subtypes, preterm PROM (pPROM) and term PROM (tPROM), are associated with disturbances in the hemostatic system and angiogenesis. This study was designed to demonstrate the role of single nucleotide polymorphisms (SNPs), localized in <i>CSF2</i...
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| Autores principales: | , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
MDPI AG
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/c03cfa237a7c423d909c68135f1c4a21 |
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| Sumario: | A prelabor rupture of membranes (PROM) and its subtypes, preterm PROM (pPROM) and term PROM (tPROM), are associated with disturbances in the hemostatic system and angiogenesis. This study was designed to demonstrate the role of single nucleotide polymorphisms (SNPs), localized in <i>CSF2</i> (rs25881), <i>FLT1</i> (rs722503), <i>TFPI</i> (C-399T) and <i>TLR9</i> (rs352140) genes, in PROM. A population of 360 women with singleton pregnancy consisted of 180 PROM cases and 180 healthy controls. A single-SNP analysis showed a similar distribution of genotypes in the studied polymorphisms between the PROM or the pPROM women and the healthy controls. Double-SNP TT variants for <i>CSF2</i> and <i>FLT1</i> polymorphisms, CC variants for <i>TLR9</i> and <i>TFPI</i> SNPs, TTC for <i>CSF2</i>, <i>FLT1</i> and <i>TLR9</i> polymorphisms, TTT for <i>FLT1</i>, <i>TLR9</i> and <i>TFPI</i> SNPs and CCCC and TTTC complex variants for all tested SNPs correlated with an increased risk of PROM after adjusting for APTT, PLT parameters and/or pregnancy disorders. The TCT variants for the <i>CSF2</i>, <i>FLT1</i> and <i>TLR9</i> SNPs and the CCTC for the <i>CSF2</i>, <i>FLT1</i>, <i>TLR9</i> and <i>TFPI</i> polymorphisms correlated with a reduced risk of PROM when corrected by PLT and APTT, respectively. We concluded that the polymorphisms of genes, involved in hemostasis and angiogenesis, contributed to PROM. |
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