Single Nucleotide Polymorphisms from CSF2, FLT1, TFPI and TLR9 Genes Are Associated with Prelabor Rupture of Membranes

A prelabor rupture of membranes (PROM) and its subtypes, preterm PROM (pPROM) and term PROM (tPROM), are associated with disturbances in the hemostatic system and angiogenesis. This study was designed to demonstrate the role of single nucleotide polymorphisms (SNPs), localized in CSF2</i...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Wioletta Izabela Wujcicka, Marian Kacerovsky, Michał Krekora, Piotr Kaczmarek, Mariusz Grzesiak
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	prelabor rupture of membranes (PROM) pPROM tPROM hemostasis angiogenesis pregnancy Genetics QH426-470
Acceso en línea:	https://doaj.org/article/c03cfa237a7c423d909c68135f1c4a21
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c03cfa237a7c423d909c68135f1c4a21
record_format	dspace
spelling	oai:doaj.org-article:c03cfa237a7c423d909c68135f1c4a212021-11-25T17:41:17ZSingle Nucleotide Polymorphisms from <i>CSF2</i>, <i>FLT1</i>, <i>TFPI</i> and <i>TLR9</i> Genes Are Associated with Prelabor Rupture of Membranes10.3390/genes121117252073-4425https://doaj.org/article/c03cfa237a7c423d909c68135f1c4a212021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4425/12/11/1725https://doaj.org/toc/2073-4425A prelabor rupture of membranes (PROM) and its subtypes, preterm PROM (pPROM) and term PROM (tPROM), are associated with disturbances in the hemostatic system and angiogenesis. This study was designed to demonstrate the role of single nucleotide polymorphisms (SNPs), localized in <i>CSF2</i> (rs25881), <i>FLT1</i> (rs722503), <i>TFPI</i> (C-399T) and <i>TLR9</i> (rs352140) genes, in PROM. A population of 360 women with singleton pregnancy consisted of 180 PROM cases and 180 healthy controls. A single-SNP analysis showed a similar distribution of genotypes in the studied polymorphisms between the PROM or the pPROM women and the healthy controls. Double-SNP TT variants for <i>CSF2</i> and <i>FLT1</i> polymorphisms, CC variants for <i>TLR9</i> and <i>TFPI</i> SNPs, TTC for <i>CSF2</i>, <i>FLT1</i> and <i>TLR9</i> polymorphisms, TTT for <i>FLT1</i>, <i>TLR9</i> and <i>TFPI</i> SNPs and CCCC and TTTC complex variants for all tested SNPs correlated with an increased risk of PROM after adjusting for APTT, PLT parameters and/or pregnancy disorders. The TCT variants for the <i>CSF2</i>, <i>FLT1</i> and <i>TLR9</i> SNPs and the CCTC for the <i>CSF2</i>, <i>FLT1</i>, <i>TLR9</i> and <i>TFPI</i> polymorphisms correlated with a reduced risk of PROM when corrected by PLT and APTT, respectively. We concluded that the polymorphisms of genes, involved in hemostasis and angiogenesis, contributed to PROM.Wioletta Izabela WujcickaMarian KacerovskyMichał KrekoraPiotr KaczmarekMariusz GrzesiakMDPI AGarticleprelabor rupture of membranes (PROM)pPROMtPROMhemostasisangiogenesispregnancyGeneticsQH426-470ENGenes, Vol 12, Iss 1725, p 1725 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	prelabor rupture of membranes (PROM) pPROM tPROM hemostasis angiogenesis pregnancy Genetics QH426-470
spellingShingle	prelabor rupture of membranes (PROM) pPROM tPROM hemostasis angiogenesis pregnancy Genetics QH426-470 Wioletta Izabela Wujcicka Marian Kacerovsky Michał Krekora Piotr Kaczmarek Mariusz Grzesiak Single Nucleotide Polymorphisms from <i>CSF2</i>, <i>FLT1</i>, <i>TFPI</i> and <i>TLR9</i> Genes Are Associated with Prelabor Rupture of Membranes
description	A prelabor rupture of membranes (PROM) and its subtypes, preterm PROM (pPROM) and term PROM (tPROM), are associated with disturbances in the hemostatic system and angiogenesis. This study was designed to demonstrate the role of single nucleotide polymorphisms (SNPs), localized in <i>CSF2</i> (rs25881), <i>FLT1</i> (rs722503), <i>TFPI</i> (C-399T) and <i>TLR9</i> (rs352140) genes, in PROM. A population of 360 women with singleton pregnancy consisted of 180 PROM cases and 180 healthy controls. A single-SNP analysis showed a similar distribution of genotypes in the studied polymorphisms between the PROM or the pPROM women and the healthy controls. Double-SNP TT variants for <i>CSF2</i> and <i>FLT1</i> polymorphisms, CC variants for <i>TLR9</i> and <i>TFPI</i> SNPs, TTC for <i>CSF2</i>, <i>FLT1</i> and <i>TLR9</i> polymorphisms, TTT for <i>FLT1</i>, <i>TLR9</i> and <i>TFPI</i> SNPs and CCCC and TTTC complex variants for all tested SNPs correlated with an increased risk of PROM after adjusting for APTT, PLT parameters and/or pregnancy disorders. The TCT variants for the <i>CSF2</i>, <i>FLT1</i> and <i>TLR9</i> SNPs and the CCTC for the <i>CSF2</i>, <i>FLT1</i>, <i>TLR9</i> and <i>TFPI</i> polymorphisms correlated with a reduced risk of PROM when corrected by PLT and APTT, respectively. We concluded that the polymorphisms of genes, involved in hemostasis and angiogenesis, contributed to PROM.
format	article
author	Wioletta Izabela Wujcicka Marian Kacerovsky Michał Krekora Piotr Kaczmarek Mariusz Grzesiak
author_facet	Wioletta Izabela Wujcicka Marian Kacerovsky Michał Krekora Piotr Kaczmarek Mariusz Grzesiak
author_sort	Wioletta Izabela Wujcicka
title	Single Nucleotide Polymorphisms from <i>CSF2</i>, <i>FLT1</i>, <i>TFPI</i> and <i>TLR9</i> Genes Are Associated with Prelabor Rupture of Membranes
title_short	Single Nucleotide Polymorphisms from <i>CSF2</i>, <i>FLT1</i>, <i>TFPI</i> and <i>TLR9</i> Genes Are Associated with Prelabor Rupture of Membranes
title_full	Single Nucleotide Polymorphisms from <i>CSF2</i>, <i>FLT1</i>, <i>TFPI</i> and <i>TLR9</i> Genes Are Associated with Prelabor Rupture of Membranes
title_fullStr	Single Nucleotide Polymorphisms from <i>CSF2</i>, <i>FLT1</i>, <i>TFPI</i> and <i>TLR9</i> Genes Are Associated with Prelabor Rupture of Membranes
title_full_unstemmed	Single Nucleotide Polymorphisms from <i>CSF2</i>, <i>FLT1</i>, <i>TFPI</i> and <i>TLR9</i> Genes Are Associated with Prelabor Rupture of Membranes
title_sort	single nucleotide polymorphisms from <i>csf2</i>, <i>flt1</i>, <i>tfpi</i> and <i>tlr9</i> genes are associated with prelabor rupture of membranes
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c03cfa237a7c423d909c68135f1c4a21
work_keys_str_mv	AT wiolettaizabelawujcicka singlenucleotidepolymorphismsfromicsf2iiflt1iitfpiianditlr9igenesareassociatedwithprelaborruptureofmembranes AT mariankacerovsky singlenucleotidepolymorphismsfromicsf2iiflt1iitfpiianditlr9igenesareassociatedwithprelaborruptureofmembranes AT michałkrekora singlenucleotidepolymorphismsfromicsf2iiflt1iitfpiianditlr9igenesareassociatedwithprelaborruptureofmembranes AT piotrkaczmarek singlenucleotidepolymorphismsfromicsf2iiflt1iitfpiianditlr9igenesareassociatedwithprelaborruptureofmembranes AT mariuszgrzesiak singlenucleotidepolymorphismsfromicsf2iiflt1iitfpiianditlr9igenesareassociatedwithprelaborruptureofmembranes
_version_	1718412129548107776

Single Nucleotide Polymorphisms from <i>CSF2</i>, <i>FLT1</i>, <i>TFPI</i> and <i>TLR9</i> Genes Are Associated with Prelabor Rupture of Membranes

Ejemplares similares