Cognitive decline in Huntington's disease in the Digitalized Arithmetic Task (DAT).
<h4>Background</h4>Efficient cognitive tasks sensitive to longitudinal deterioration in small cohorts of Huntington's disease (HD) patients are lacking in HD research. We thus developed and assessed the digitized arithmetic task (DAT), which combines inner language and executive fun...
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2021
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oai:doaj.org-article:c04397e7a29a4b84ab292fc83727f04d2021-12-02T20:17:40ZCognitive decline in Huntington's disease in the Digitalized Arithmetic Task (DAT).1932-620310.1371/journal.pone.0253064https://doaj.org/article/c04397e7a29a4b84ab292fc83727f04d2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0253064https://doaj.org/toc/1932-6203<h4>Background</h4>Efficient cognitive tasks sensitive to longitudinal deterioration in small cohorts of Huntington's disease (HD) patients are lacking in HD research. We thus developed and assessed the digitized arithmetic task (DAT), which combines inner language and executive functions in approximately 4 minutes.<h4>Methods</h4>We assessed the psychometric properties of DAT in three languages, across four European sites, in 77 early-stage HD patients (age: 52 ± 11 years; 27 females), and 57 controls (age: 50 ± 10, 31 females). Forty-eight HD patients and 34 controls were followed up to one year with 96 participants who underwent MRI brain imaging (HD patients = 46) at baseline and 50 participants (HD patients = 22) at one year. Linear mixed models and Pearson correlations were used to assess associations with clinical assessment.<h4>Results</h4>At baseline, HD patients were less accurate (p = 0.0002) with increased response time (p<0.0001) when compared to DAT in controls. Test-retest reliability in HD patients ranged from good to excellent for response time (range: 0.63-0.79) and from questionable to acceptable for accuracy (range: r = 0.52-0.69). Only DAT, the Mattis Dementia Rating Scale, the Symbol Digit Modalities Test, and Total Functional Capacity scores were able to detect a decline within a one-year follow-up in HD patients (all p< 0.05). In contrast with all the other cognitive tasks, DAT correlated with striatal atrophy over time (p = 0.037) but not with motor impairment.<h4>Conclusions</h4>DAT is fast, reliable, motor-free, applicable in several languages, and able to unmask cognitive decline correlated with striatal atrophy in small cohorts of HD patients. This likely makes it a useful endpoint in future trials for HD and other neurodegenerative diseases.Marine LunvenJennifer Hamet BagnouKatia YoussovAlexis GabadinhoRafika FlissJustine MontillotEtienne AudureauBlanche BapstGraça MorgadoRalf ReilmannRobin SchubertMonica BusseDavid CraufurdRenaud MassartAnne RosserAnne-Catherine Bachoud-LéviPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0253064 (2021) |
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DOAJ |
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DOAJ |
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Medicine R Science Q |
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Medicine R Science Q Marine Lunven Jennifer Hamet Bagnou Katia Youssov Alexis Gabadinho Rafika Fliss Justine Montillot Etienne Audureau Blanche Bapst Graça Morgado Ralf Reilmann Robin Schubert Monica Busse David Craufurd Renaud Massart Anne Rosser Anne-Catherine Bachoud-Lévi Cognitive decline in Huntington's disease in the Digitalized Arithmetic Task (DAT). |
| description |
<h4>Background</h4>Efficient cognitive tasks sensitive to longitudinal deterioration in small cohorts of Huntington's disease (HD) patients are lacking in HD research. We thus developed and assessed the digitized arithmetic task (DAT), which combines inner language and executive functions in approximately 4 minutes.<h4>Methods</h4>We assessed the psychometric properties of DAT in three languages, across four European sites, in 77 early-stage HD patients (age: 52 ± 11 years; 27 females), and 57 controls (age: 50 ± 10, 31 females). Forty-eight HD patients and 34 controls were followed up to one year with 96 participants who underwent MRI brain imaging (HD patients = 46) at baseline and 50 participants (HD patients = 22) at one year. Linear mixed models and Pearson correlations were used to assess associations with clinical assessment.<h4>Results</h4>At baseline, HD patients were less accurate (p = 0.0002) with increased response time (p<0.0001) when compared to DAT in controls. Test-retest reliability in HD patients ranged from good to excellent for response time (range: 0.63-0.79) and from questionable to acceptable for accuracy (range: r = 0.52-0.69). Only DAT, the Mattis Dementia Rating Scale, the Symbol Digit Modalities Test, and Total Functional Capacity scores were able to detect a decline within a one-year follow-up in HD patients (all p< 0.05). In contrast with all the other cognitive tasks, DAT correlated with striatal atrophy over time (p = 0.037) but not with motor impairment.<h4>Conclusions</h4>DAT is fast, reliable, motor-free, applicable in several languages, and able to unmask cognitive decline correlated with striatal atrophy in small cohorts of HD patients. This likely makes it a useful endpoint in future trials for HD and other neurodegenerative diseases. |
| format |
article |
| author |
Marine Lunven Jennifer Hamet Bagnou Katia Youssov Alexis Gabadinho Rafika Fliss Justine Montillot Etienne Audureau Blanche Bapst Graça Morgado Ralf Reilmann Robin Schubert Monica Busse David Craufurd Renaud Massart Anne Rosser Anne-Catherine Bachoud-Lévi |
| author_facet |
Marine Lunven Jennifer Hamet Bagnou Katia Youssov Alexis Gabadinho Rafika Fliss Justine Montillot Etienne Audureau Blanche Bapst Graça Morgado Ralf Reilmann Robin Schubert Monica Busse David Craufurd Renaud Massart Anne Rosser Anne-Catherine Bachoud-Lévi |
| author_sort |
Marine Lunven |
| title |
Cognitive decline in Huntington's disease in the Digitalized Arithmetic Task (DAT). |
| title_short |
Cognitive decline in Huntington's disease in the Digitalized Arithmetic Task (DAT). |
| title_full |
Cognitive decline in Huntington's disease in the Digitalized Arithmetic Task (DAT). |
| title_fullStr |
Cognitive decline in Huntington's disease in the Digitalized Arithmetic Task (DAT). |
| title_full_unstemmed |
Cognitive decline in Huntington's disease in the Digitalized Arithmetic Task (DAT). |
| title_sort |
cognitive decline in huntington's disease in the digitalized arithmetic task (dat). |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2021 |
| url |
https://doaj.org/article/c04397e7a29a4b84ab292fc83727f04d |
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