The G127V variant of the prion protein interferes with dimer formation in vitro but not in cellulo

The G127V variant of the prion protein interferes with dimer formation in vitro but not in cellulo

Abstract Scrapie prion, PrPSc, formation is the central event of all types of transmissible spongiform encephalopathies (TSEs), while the pathway with possible intermediates and their mechanism of formation from the normal isoform of prion (PrP), remains not fully understood. Recently, the G127V var...

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Autores principales: Sudheer Babu Sangeetham, Anna Dorothee Engelke, Elfrieda Fodor, Sarah Laura Krausz, Jörg Tatzelt, Ervin Welker
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/c043bbcf337e4e7aaaff2a79aaf27566
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