Critical Review of Synthesis, Toxicology and Detection of Acyclovir

Acyclovir (ACV) is an effective and selective antiviral drug, and the study of its toxicology and the use of appropriate detection techniques to control its toxicity at safe levels are extremely important for medicine efforts and human health. This review discusses the mechanism driving ACV’s abilit...

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Autores principales:	Yan-Ping Wei, Liang-Yuan Yao, Yi-Yong Wu, Xia Liu, Li-Hong Peng, Ya-Ling Tian, Jian-Hua Ding, Kang-Hua Li, Quan-Guo He
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	acyclovir pharmacology synthesis toxicology analytical methods Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/c044ef2226054a1aabad05e2213b5b6a
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spelling	oai:doaj.org-article:c044ef2226054a1aabad05e2213b5b6a2021-11-11T18:32:54ZCritical Review of Synthesis, Toxicology and Detection of Acyclovir10.3390/molecules262165661420-3049https://doaj.org/article/c044ef2226054a1aabad05e2213b5b6a2021-10-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/21/6566https://doaj.org/toc/1420-3049Acyclovir (ACV) is an effective and selective antiviral drug, and the study of its toxicology and the use of appropriate detection techniques to control its toxicity at safe levels are extremely important for medicine efforts and human health. This review discusses the mechanism driving ACV’s ability to inhibit viral coding, starting from its development and pharmacology. A comprehensive summary of the existing preparation methods and synthetic materials, such as 5-aminoimidazole-4-carboxamide, guanine and its derivatives, and other purine derivatives, is presented to elucidate the preparation of ACV in detail. In addition, it presents valuable analytical procedures for the toxicological studies of ACV, which are essential for human use and dosing. Analytical methods, including spectrophotometry, high performance liquid chromatography (HPLC), liquid chromatography/tandem mass spectrometry (LC-MS/MS), electrochemical sensors, molecularly imprinted polymers (MIPs), and flow injection–chemiluminescence (FI-CL) are also highlighted. A brief description of the characteristics of each of these methods is also presented. Finally, insight is provided for the development of ACV to drive further innovation of ACV in pharmaceutical applications. This review provides a comprehensive summary of the past life and future challenges of ACV.Yan-Ping WeiLiang-Yuan YaoYi-Yong WuXia LiuLi-Hong PengYa-Ling TianJian-Hua DingKang-Hua LiQuan-Guo HeMDPI AGarticleacyclovirpharmacologysynthesistoxicologyanalytical methodsOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6566, p 6566 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	acyclovir pharmacology synthesis toxicology analytical methods Organic chemistry QD241-441
spellingShingle	acyclovir pharmacology synthesis toxicology analytical methods Organic chemistry QD241-441 Yan-Ping Wei Liang-Yuan Yao Yi-Yong Wu Xia Liu Li-Hong Peng Ya-Ling Tian Jian-Hua Ding Kang-Hua Li Quan-Guo He Critical Review of Synthesis, Toxicology and Detection of Acyclovir
description	Acyclovir (ACV) is an effective and selective antiviral drug, and the study of its toxicology and the use of appropriate detection techniques to control its toxicity at safe levels are extremely important for medicine efforts and human health. This review discusses the mechanism driving ACV’s ability to inhibit viral coding, starting from its development and pharmacology. A comprehensive summary of the existing preparation methods and synthetic materials, such as 5-aminoimidazole-4-carboxamide, guanine and its derivatives, and other purine derivatives, is presented to elucidate the preparation of ACV in detail. In addition, it presents valuable analytical procedures for the toxicological studies of ACV, which are essential for human use and dosing. Analytical methods, including spectrophotometry, high performance liquid chromatography (HPLC), liquid chromatography/tandem mass spectrometry (LC-MS/MS), electrochemical sensors, molecularly imprinted polymers (MIPs), and flow injection–chemiluminescence (FI-CL) are also highlighted. A brief description of the characteristics of each of these methods is also presented. Finally, insight is provided for the development of ACV to drive further innovation of ACV in pharmaceutical applications. This review provides a comprehensive summary of the past life and future challenges of ACV.
format	article
author	Yan-Ping Wei Liang-Yuan Yao Yi-Yong Wu Xia Liu Li-Hong Peng Ya-Ling Tian Jian-Hua Ding Kang-Hua Li Quan-Guo He
author_facet	Yan-Ping Wei Liang-Yuan Yao Yi-Yong Wu Xia Liu Li-Hong Peng Ya-Ling Tian Jian-Hua Ding Kang-Hua Li Quan-Guo He
author_sort	Yan-Ping Wei
title	Critical Review of Synthesis, Toxicology and Detection of Acyclovir
title_short	Critical Review of Synthesis, Toxicology and Detection of Acyclovir
title_full	Critical Review of Synthesis, Toxicology and Detection of Acyclovir
title_fullStr	Critical Review of Synthesis, Toxicology and Detection of Acyclovir
title_full_unstemmed	Critical Review of Synthesis, Toxicology and Detection of Acyclovir
title_sort	critical review of synthesis, toxicology and detection of acyclovir
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c044ef2226054a1aabad05e2213b5b6a
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Critical Review of Synthesis, Toxicology and Detection of Acyclovir

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