Capsid-like particles decorated with the SARS-CoV-2 receptor-binding domain elicit strong virus neutralization activity
Here the authors generate a capsid-like particle based vaccine candidate displaying the receptor-binding domain of the SARS-CoV-2 spike protein and show induction of neutralizing antibodies after intramuscular prime-boost immunization in mice.
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Nature Portfolio
2021
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oai:doaj.org-article:c047e4469bfc4df49317bf7ddb5a7a952021-12-02T14:01:26ZCapsid-like particles decorated with the SARS-CoV-2 receptor-binding domain elicit strong virus neutralization activity10.1038/s41467-020-20251-82041-1723https://doaj.org/article/c047e4469bfc4df49317bf7ddb5a7a952021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20251-8https://doaj.org/toc/2041-1723Here the authors generate a capsid-like particle based vaccine candidate displaying the receptor-binding domain of the SARS-CoV-2 spike protein and show induction of neutralizing antibodies after intramuscular prime-boost immunization in mice.Cyrielle FougerouxLouise GoksøyrManja IdornVladislav SorokaSebenzile K. MyeniRobert DagilChristoph M. JanitzekMax SøgaardKara-Lee AvesEmma W. HorstedSayit Mahmut ErdoğanTobias GustavssonJerzy DoroszStine ClemmensenLaurits FredsgaardSusan ThraneElena E. Vidal-CalvoPaul KhaliféThomas M. HulenSwati ChoudharyMichael TheisenSusheel K. SinghAsier Garcia-SenosiainLinda Van OostenGorben PijlmanBettina HierzbergerTanja DomeyerBlanka W. NalewajekAnette StrøbækMagdalena SkrzypczakLaura F. AnderssonSøren BuusAnette Stryhn BuusJan Pravsgaard ChristensenTim J. DaleboutKasper IversenLene H. HarritshøjBenjamin MordmüllerHenrik UllumLine S. ReinertWillem Adriaan de JonghMarjolein KikkertSøren R. PaludanThor G. TheanderMorten A. NielsenAli SalantiAdam F. SanderNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Cyrielle Fougeroux Louise Goksøyr Manja Idorn Vladislav Soroka Sebenzile K. Myeni Robert Dagil Christoph M. Janitzek Max Søgaard Kara-Lee Aves Emma W. Horsted Sayit Mahmut Erdoğan Tobias Gustavsson Jerzy Dorosz Stine Clemmensen Laurits Fredsgaard Susan Thrane Elena E. Vidal-Calvo Paul Khalifé Thomas M. Hulen Swati Choudhary Michael Theisen Susheel K. Singh Asier Garcia-Senosiain Linda Van Oosten Gorben Pijlman Bettina Hierzberger Tanja Domeyer Blanka W. Nalewajek Anette Strøbæk Magdalena Skrzypczak Laura F. Andersson Søren Buus Anette Stryhn Buus Jan Pravsgaard Christensen Tim J. Dalebout Kasper Iversen Lene H. Harritshøj Benjamin Mordmüller Henrik Ullum Line S. Reinert Willem Adriaan de Jongh Marjolein Kikkert Søren R. Paludan Thor G. Theander Morten A. Nielsen Ali Salanti Adam F. Sander Capsid-like particles decorated with the SARS-CoV-2 receptor-binding domain elicit strong virus neutralization activity |
| description |
Here the authors generate a capsid-like particle based vaccine candidate displaying the receptor-binding domain of the SARS-CoV-2 spike protein and show induction of neutralizing antibodies after intramuscular prime-boost immunization in mice. |
| format |
article |
| author |
Cyrielle Fougeroux Louise Goksøyr Manja Idorn Vladislav Soroka Sebenzile K. Myeni Robert Dagil Christoph M. Janitzek Max Søgaard Kara-Lee Aves Emma W. Horsted Sayit Mahmut Erdoğan Tobias Gustavsson Jerzy Dorosz Stine Clemmensen Laurits Fredsgaard Susan Thrane Elena E. Vidal-Calvo Paul Khalifé Thomas M. Hulen Swati Choudhary Michael Theisen Susheel K. Singh Asier Garcia-Senosiain Linda Van Oosten Gorben Pijlman Bettina Hierzberger Tanja Domeyer Blanka W. Nalewajek Anette Strøbæk Magdalena Skrzypczak Laura F. Andersson Søren Buus Anette Stryhn Buus Jan Pravsgaard Christensen Tim J. Dalebout Kasper Iversen Lene H. Harritshøj Benjamin Mordmüller Henrik Ullum Line S. Reinert Willem Adriaan de Jongh Marjolein Kikkert Søren R. Paludan Thor G. Theander Morten A. Nielsen Ali Salanti Adam F. Sander |
| author_facet |
Cyrielle Fougeroux Louise Goksøyr Manja Idorn Vladislav Soroka Sebenzile K. Myeni Robert Dagil Christoph M. Janitzek Max Søgaard Kara-Lee Aves Emma W. Horsted Sayit Mahmut Erdoğan Tobias Gustavsson Jerzy Dorosz Stine Clemmensen Laurits Fredsgaard Susan Thrane Elena E. Vidal-Calvo Paul Khalifé Thomas M. Hulen Swati Choudhary Michael Theisen Susheel K. Singh Asier Garcia-Senosiain Linda Van Oosten Gorben Pijlman Bettina Hierzberger Tanja Domeyer Blanka W. Nalewajek Anette Strøbæk Magdalena Skrzypczak Laura F. Andersson Søren Buus Anette Stryhn Buus Jan Pravsgaard Christensen Tim J. Dalebout Kasper Iversen Lene H. Harritshøj Benjamin Mordmüller Henrik Ullum Line S. Reinert Willem Adriaan de Jongh Marjolein Kikkert Søren R. Paludan Thor G. Theander Morten A. Nielsen Ali Salanti Adam F. Sander |
| author_sort |
Cyrielle Fougeroux |
| title |
Capsid-like particles decorated with the SARS-CoV-2 receptor-binding domain elicit strong virus neutralization activity |
| title_short |
Capsid-like particles decorated with the SARS-CoV-2 receptor-binding domain elicit strong virus neutralization activity |
| title_full |
Capsid-like particles decorated with the SARS-CoV-2 receptor-binding domain elicit strong virus neutralization activity |
| title_fullStr |
Capsid-like particles decorated with the SARS-CoV-2 receptor-binding domain elicit strong virus neutralization activity |
| title_full_unstemmed |
Capsid-like particles decorated with the SARS-CoV-2 receptor-binding domain elicit strong virus neutralization activity |
| title_sort |
capsid-like particles decorated with the sars-cov-2 receptor-binding domain elicit strong virus neutralization activity |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/c047e4469bfc4df49317bf7ddb5a7a95 |
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