The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery

SUMO and ubiquitin are key signal transducers in several cellular processes including the DNA-damage response. Here the authors describe a method for selective enrichment of ubiquitin substrates for E3 ligases from complex cellular proteomes and identify the SUMO conjugation machinery as direct RNF4...

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Autores principales:	Ramesh Kumar, Román González-Prieto, Zhenyu Xiao, Matty Verlaan-de Vries, Alfred C. O. Vertegaal
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c048b9fb858b4d479c21ebe546d44acd
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spelling	oai:doaj.org-article:c048b9fb858b4d479c21ebe546d44acd2021-12-02T15:38:50ZThe STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery10.1038/s41467-017-01900-x2041-1723https://doaj.org/article/c048b9fb858b4d479c21ebe546d44acd2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01900-xhttps://doaj.org/toc/2041-1723SUMO and ubiquitin are key signal transducers in several cellular processes including the DNA-damage response. Here the authors describe a method for selective enrichment of ubiquitin substrates for E3 ligases from complex cellular proteomes and identify the SUMO conjugation machinery as direct RNF4 substrates.Ramesh KumarRomán González-PrietoZhenyu XiaoMatty Verlaan-de VriesAlfred C. O. VertegaalNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ramesh Kumar Román González-Prieto Zhenyu Xiao Matty Verlaan-de Vries Alfred C. O. Vertegaal The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery
description	SUMO and ubiquitin are key signal transducers in several cellular processes including the DNA-damage response. Here the authors describe a method for selective enrichment of ubiquitin substrates for E3 ligases from complex cellular proteomes and identify the SUMO conjugation machinery as direct RNF4 substrates.
format	article
author	Ramesh Kumar Román González-Prieto Zhenyu Xiao Matty Verlaan-de Vries Alfred C. O. Vertegaal
author_facet	Ramesh Kumar Román González-Prieto Zhenyu Xiao Matty Verlaan-de Vries Alfred C. O. Vertegaal
author_sort	Ramesh Kumar
title	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery
title_short	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery
title_full	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery
title_fullStr	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery
title_full_unstemmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery
title_sort	stubl rnf4 regulates protein group sumoylation by targeting the sumo conjugation machinery
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c048b9fb858b4d479c21ebe546d44acd
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The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery

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