The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery

SUMO and ubiquitin are key signal transducers in several cellular processes including the DNA-damage response. Here the authors describe a method for selective enrichment of ubiquitin substrates for E3 ligases from complex cellular proteomes and identify the SUMO conjugation machinery as direct RNF4...

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Autores principales: Ramesh Kumar, Román González-Prieto, Zhenyu Xiao, Matty Verlaan-de Vries, Alfred C. O. Vertegaal
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
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Acceso en línea:https://doaj.org/article/c048b9fb858b4d479c21ebe546d44acd
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