Multiscale dynamical network mechanisms underlying aging of an online organism from birth to death

Abstract We present the continuous-time evolution of an online organism network from birth to death which crosses all organizational and temporal scales, from individual components through to the mesoscopic and entire system scale. These continuous-time data reveal a lifespan driven by punctuated, r...

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Autores principales:	M. Zheng, Z. Cao, Y. Vorobyeva, P. Manrique, C. Song, N. F. Johnson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c04a84bac37647ce99b4a7e542fc5295
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spelling	oai:doaj.org-article:c04a84bac37647ce99b4a7e542fc52952021-12-02T15:08:23ZMultiscale dynamical network mechanisms underlying aging of an online organism from birth to death10.1038/s41598-018-22027-z2045-2322https://doaj.org/article/c04a84bac37647ce99b4a7e542fc52952018-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-22027-zhttps://doaj.org/toc/2045-2322Abstract We present the continuous-time evolution of an online organism network from birth to death which crosses all organizational and temporal scales, from individual components through to the mesoscopic and entire system scale. These continuous-time data reveal a lifespan driven by punctuated, real-time co-evolution of the structural and functional networks. Aging sees these structural and functional networks gradually diverge in terms of their small-worldness and eventually their connectivity. Dying emerges as an extended process associated with the formation of large but disjoint functional sub-networks together with an increasingly detached core. Our mathematical model quantifies the very different impacts that interventions will have on the overall lifetime, period of initial growth, peak of potency, and duration of old age, depending on when and how they are administered. In addition to their direct relevance to online extremism, our findings may offer insight into aging in other network systems of comparable complexity for which extensive in vivo data is not yet available.M. ZhengZ. CaoY. VorobyevaP. ManriqueC. SongN. F. JohnsonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q M. Zheng Z. Cao Y. Vorobyeva P. Manrique C. Song N. F. Johnson Multiscale dynamical network mechanisms underlying aging of an online organism from birth to death
description	Abstract We present the continuous-time evolution of an online organism network from birth to death which crosses all organizational and temporal scales, from individual components through to the mesoscopic and entire system scale. These continuous-time data reveal a lifespan driven by punctuated, real-time co-evolution of the structural and functional networks. Aging sees these structural and functional networks gradually diverge in terms of their small-worldness and eventually their connectivity. Dying emerges as an extended process associated with the formation of large but disjoint functional sub-networks together with an increasingly detached core. Our mathematical model quantifies the very different impacts that interventions will have on the overall lifetime, period of initial growth, peak of potency, and duration of old age, depending on when and how they are administered. In addition to their direct relevance to online extremism, our findings may offer insight into aging in other network systems of comparable complexity for which extensive in vivo data is not yet available.
format	article
author	M. Zheng Z. Cao Y. Vorobyeva P. Manrique C. Song N. F. Johnson
author_facet	M. Zheng Z. Cao Y. Vorobyeva P. Manrique C. Song N. F. Johnson
author_sort	M. Zheng
title	Multiscale dynamical network mechanisms underlying aging of an online organism from birth to death
title_short	Multiscale dynamical network mechanisms underlying aging of an online organism from birth to death
title_full	Multiscale dynamical network mechanisms underlying aging of an online organism from birth to death
title_fullStr	Multiscale dynamical network mechanisms underlying aging of an online organism from birth to death
title_full_unstemmed	Multiscale dynamical network mechanisms underlying aging of an online organism from birth to death
title_sort	multiscale dynamical network mechanisms underlying aging of an online organism from birth to death
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/c04a84bac37647ce99b4a7e542fc5295
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Multiscale dynamical network mechanisms underlying aging of an online organism from birth to death

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