Munc13-1 and Munc18-1 together prevent NSF-dependent de-priming of synaptic vesicles

The molecular mechanism underlying the generation and maintenance of the readily releasable pool composed of primed synaptic vesicles is only partially known. Here the authors show that in mouse primary neurons, Munc13-1 and Munc18-1 stabilize primed synaptic vesicles by preventing NSF-dependent de-...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Enqi He, Keimpe Wierda, Rhode van Westen, Jurjen H. Broeke, Ruud F. Toonen, L. Niels Cornelisse, Matthijs Verhage
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c04e466c0f2a462ab9e60635e82e61e1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c04e466c0f2a462ab9e60635e82e61e1
record_format	dspace
spelling	oai:doaj.org-article:c04e466c0f2a462ab9e60635e82e61e12021-12-02T15:38:40ZMunc13-1 and Munc18-1 together prevent NSF-dependent de-priming of synaptic vesicles10.1038/ncomms159152041-1723https://doaj.org/article/c04e466c0f2a462ab9e60635e82e61e12017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15915https://doaj.org/toc/2041-1723The molecular mechanism underlying the generation and maintenance of the readily releasable pool composed of primed synaptic vesicles is only partially known. Here the authors show that in mouse primary neurons, Munc13-1 and Munc18-1 stabilize primed synaptic vesicles by preventing NSF-dependent de-priming.Enqi HeKeimpe WierdaRhode van WestenJurjen H. BroekeRuud F. ToonenL. Niels CornelisseMatthijs VerhageNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Enqi He Keimpe Wierda Rhode van Westen Jurjen H. Broeke Ruud F. Toonen L. Niels Cornelisse Matthijs Verhage Munc13-1 and Munc18-1 together prevent NSF-dependent de-priming of synaptic vesicles
description	The molecular mechanism underlying the generation and maintenance of the readily releasable pool composed of primed synaptic vesicles is only partially known. Here the authors show that in mouse primary neurons, Munc13-1 and Munc18-1 stabilize primed synaptic vesicles by preventing NSF-dependent de-priming.
format	article
author	Enqi He Keimpe Wierda Rhode van Westen Jurjen H. Broeke Ruud F. Toonen L. Niels Cornelisse Matthijs Verhage
author_facet	Enqi He Keimpe Wierda Rhode van Westen Jurjen H. Broeke Ruud F. Toonen L. Niels Cornelisse Matthijs Verhage
author_sort	Enqi He
title	Munc13-1 and Munc18-1 together prevent NSF-dependent de-priming of synaptic vesicles
title_short	Munc13-1 and Munc18-1 together prevent NSF-dependent de-priming of synaptic vesicles
title_full	Munc13-1 and Munc18-1 together prevent NSF-dependent de-priming of synaptic vesicles
title_fullStr	Munc13-1 and Munc18-1 together prevent NSF-dependent de-priming of synaptic vesicles
title_full_unstemmed	Munc13-1 and Munc18-1 together prevent NSF-dependent de-priming of synaptic vesicles
title_sort	munc13-1 and munc18-1 together prevent nsf-dependent de-priming of synaptic vesicles
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c04e466c0f2a462ab9e60635e82e61e1
work_keys_str_mv	AT enqihe munc131andmunc181togetherpreventnsfdependentdeprimingofsynapticvesicles AT keimpewierda munc131andmunc181togetherpreventnsfdependentdeprimingofsynapticvesicles AT rhodevanwesten munc131andmunc181togetherpreventnsfdependentdeprimingofsynapticvesicles AT jurjenhbroeke munc131andmunc181togetherpreventnsfdependentdeprimingofsynapticvesicles AT ruudftoonen munc131andmunc181togetherpreventnsfdependentdeprimingofsynapticvesicles AT lnielscornelisse munc131andmunc181togetherpreventnsfdependentdeprimingofsynapticvesicles AT matthijsverhage munc131andmunc181togetherpreventnsfdependentdeprimingofsynapticvesicles
_version_	1718386137993576448

Munc13-1 and Munc18-1 together prevent NSF-dependent de-priming of synaptic vesicles

Ejemplares similares