Thrombus-Targeting Polymeric Nanocarriers and Their Biomedical Applications in Thrombolytic Therapy

Due to the high morbidity and mortality of cardiovascular diseases, there is an urgent need for research on antithrombotic strategies. In view of the short half-life, insufficient drug penetration, poor targeting capabilities, and hemorrhagic side-effects of traditional thrombus treatment methods, t...

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Autores principales:	Qixiao Guan, Hongjing Dou
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	thrombosis polymeric nanocarriers targeted delivery biomimetic technology antithrombotic strategies Physiology QP1-981
Acceso en línea:	https://doaj.org/article/c04e54a172d945c490a8f0e9be71f4f3
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spelling	oai:doaj.org-article:c04e54a172d945c490a8f0e9be71f4f32021-12-01T18:18:19ZThrombus-Targeting Polymeric Nanocarriers and Their Biomedical Applications in Thrombolytic Therapy1664-042X10.3389/fphys.2021.763085https://doaj.org/article/c04e54a172d945c490a8f0e9be71f4f32021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphys.2021.763085/fullhttps://doaj.org/toc/1664-042XDue to the high morbidity and mortality of cardiovascular diseases, there is an urgent need for research on antithrombotic strategies. In view of the short half-life, insufficient drug penetration, poor targeting capabilities, and hemorrhagic side-effects of traditional thrombus treatment methods, the combination of thrombolytic therapy and nanocarriers brought by the development of nanotechnology in recent years may provide effective solutions for these undesirable side-effects caused by insufficient targeting. Polymeric nanocarriers, based on macromolecules and various functional groups, can connect specific targeting molecules together through chemical modification to achieve the protection and targeted delivery of thrombolytic drugs. However, simple chemical molecular modifications may be easily affected by the physiological environment encountered in the circulatory system. Therefore, the modification of nanocarriers with cell membranes can provide camouflage to these platforms and help to extend their circulation time while also imparting them with the biological functions of cell membranes, thus providing them with precise targeting capabilities, among which the most important is the biological modification of platelet membranes. In addition, some nanoparticles with their own therapeutic functions have also been developed, such as polypyrrole, which can exhibit a photothermal effect to induce thrombolysis. Herein, combined with the mechanism of thrombosis and thrombolysis, we outline the recent advances achieved with thrombus-targeting nanocarriers with regard to thrombosis treatment. On this basis, the design considerations, advantages, and challenges of these thrombolytic therapies in clinical transformation are discussed.Qixiao GuanHongjing DouFrontiers Media S.A.articlethrombosispolymeric nanocarrierstargeted deliverybiomimetic technologyantithrombotic strategiesPhysiologyQP1-981ENFrontiers in Physiology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	thrombosis polymeric nanocarriers targeted delivery biomimetic technology antithrombotic strategies Physiology QP1-981
spellingShingle	thrombosis polymeric nanocarriers targeted delivery biomimetic technology antithrombotic strategies Physiology QP1-981 Qixiao Guan Hongjing Dou Thrombus-Targeting Polymeric Nanocarriers and Their Biomedical Applications in Thrombolytic Therapy
description	Due to the high morbidity and mortality of cardiovascular diseases, there is an urgent need for research on antithrombotic strategies. In view of the short half-life, insufficient drug penetration, poor targeting capabilities, and hemorrhagic side-effects of traditional thrombus treatment methods, the combination of thrombolytic therapy and nanocarriers brought by the development of nanotechnology in recent years may provide effective solutions for these undesirable side-effects caused by insufficient targeting. Polymeric nanocarriers, based on macromolecules and various functional groups, can connect specific targeting molecules together through chemical modification to achieve the protection and targeted delivery of thrombolytic drugs. However, simple chemical molecular modifications may be easily affected by the physiological environment encountered in the circulatory system. Therefore, the modification of nanocarriers with cell membranes can provide camouflage to these platforms and help to extend their circulation time while also imparting them with the biological functions of cell membranes, thus providing them with precise targeting capabilities, among which the most important is the biological modification of platelet membranes. In addition, some nanoparticles with their own therapeutic functions have also been developed, such as polypyrrole, which can exhibit a photothermal effect to induce thrombolysis. Herein, combined with the mechanism of thrombosis and thrombolysis, we outline the recent advances achieved with thrombus-targeting nanocarriers with regard to thrombosis treatment. On this basis, the design considerations, advantages, and challenges of these thrombolytic therapies in clinical transformation are discussed.
format	article
author	Qixiao Guan Hongjing Dou
author_facet	Qixiao Guan Hongjing Dou
author_sort	Qixiao Guan
title	Thrombus-Targeting Polymeric Nanocarriers and Their Biomedical Applications in Thrombolytic Therapy
title_short	Thrombus-Targeting Polymeric Nanocarriers and Their Biomedical Applications in Thrombolytic Therapy
title_full	Thrombus-Targeting Polymeric Nanocarriers and Their Biomedical Applications in Thrombolytic Therapy
title_fullStr	Thrombus-Targeting Polymeric Nanocarriers and Their Biomedical Applications in Thrombolytic Therapy
title_full_unstemmed	Thrombus-Targeting Polymeric Nanocarriers and Their Biomedical Applications in Thrombolytic Therapy
title_sort	thrombus-targeting polymeric nanocarriers and their biomedical applications in thrombolytic therapy
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/c04e54a172d945c490a8f0e9be71f4f3
work_keys_str_mv	AT qixiaoguan thrombustargetingpolymericnanocarriersandtheirbiomedicalapplicationsinthrombolytictherapy AT hongjingdou thrombustargetingpolymericnanocarriersandtheirbiomedicalapplicationsinthrombolytictherapy
_version_	1718404718443626496

Thrombus-Targeting Polymeric Nanocarriers and Their Biomedical Applications in Thrombolytic Therapy

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