STUDY OF PREVENTIVE EFFECT OF MELATONIN ON HIGH DOSE VANCOMYCIN INDUCED NEPHROTOXICITY IN RABBITS

Objective: To explore the nephropreventive effects of melatonin on vancomycin-induced nephrotoxicity in rabbits. Study Design: Laboratory based randomized controlled trial. Place and Duration of Study: Department of Pharmacology and Therapeutics, Army Medical College, Rawalpindi, from May 2...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Shabana Ali, Mahwish Qaisarani, Kulsoom Farhat, Akbar Waheed
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2018
Materias:	melatonin nephrotoxicity Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/c0502a461a88433da7d2afa2c57cec99
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c0502a461a88433da7d2afa2c57cec99
record_format	dspace
spelling	oai:doaj.org-article:c0502a461a88433da7d2afa2c57cec992021-11-26T03:22:01ZSTUDY OF PREVENTIVE EFFECT OF MELATONIN ON HIGH DOSE VANCOMYCIN INDUCED NEPHROTOXICITY IN RABBITS0030-96482411-8842https://doaj.org/article/c0502a461a88433da7d2afa2c57cec992018-12-01T00:00:00Zhttps://www.pafmj.org/index.php/PAFMJ/article/view/2560/2098https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To explore the nephropreventive effects of melatonin on vancomycin-induced nephrotoxicity in rabbits. Study Design: Laboratory based randomized controlled trial. Place and Duration of Study: Department of Pharmacology and Therapeutics, Army Medical College, Rawalpindi, from May 2017 to June 2017. Material and Methods: Seventy rabbits were divided into three groups. Group A served as a control group (n=10), group B (n=30) received I/P vancomycin 200mg/kg twice a day for seven days while group C (n=30) received I/P melatonin 10mg/kg 30 minutes prior to vancomycin administration for seven days. Animals were sacrificed on the eighth day. Biochemical analysis was done for serum urea, creatinine, sodium and potassium on day 0 and day 8. Kidneys were sent for histopathology. Statistical analysis was carried out by using Microsoft Office Excel 2010 and SPSS version 21. One way ANOVA, followed by ‘Post Hoc Tukey’ test was used for biochemical parameters. Results: Vancomycin induced massive renal damage (grade III) and led to elevation in biochemical parameters, while melatonin pretreatment prevented the renal damage and the biochemical parameters were also significantly reduced with a p-value of <0.001 for serum urea, creatinine and potassium but had insignificant p-value for serum sodium levels. Conclusion: The study outcome indicates the potential of melatonin to prevent Vancomycin induced nephrotoxicity by virtue of its antioxidant property.Shabana AliMahwish QaisaraniKulsoom FarhatAkbar WaheedArmy Medical College RawalpindiarticlemelatoninnephrotoxicityMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 68, Iss 6, Pp 1625-1629 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	melatonin nephrotoxicity Medicine R Medicine (General) R5-920
spellingShingle	melatonin nephrotoxicity Medicine R Medicine (General) R5-920 Shabana Ali Mahwish Qaisarani Kulsoom Farhat Akbar Waheed STUDY OF PREVENTIVE EFFECT OF MELATONIN ON HIGH DOSE VANCOMYCIN INDUCED NEPHROTOXICITY IN RABBITS
description	Objective: To explore the nephropreventive effects of melatonin on vancomycin-induced nephrotoxicity in rabbits. Study Design: Laboratory based randomized controlled trial. Place and Duration of Study: Department of Pharmacology and Therapeutics, Army Medical College, Rawalpindi, from May 2017 to June 2017. Material and Methods: Seventy rabbits were divided into three groups. Group A served as a control group (n=10), group B (n=30) received I/P vancomycin 200mg/kg twice a day for seven days while group C (n=30) received I/P melatonin 10mg/kg 30 minutes prior to vancomycin administration for seven days. Animals were sacrificed on the eighth day. Biochemical analysis was done for serum urea, creatinine, sodium and potassium on day 0 and day 8. Kidneys were sent for histopathology. Statistical analysis was carried out by using Microsoft Office Excel 2010 and SPSS version 21. One way ANOVA, followed by ‘Post Hoc Tukey’ test was used for biochemical parameters. Results: Vancomycin induced massive renal damage (grade III) and led to elevation in biochemical parameters, while melatonin pretreatment prevented the renal damage and the biochemical parameters were also significantly reduced with a p-value of <0.001 for serum urea, creatinine and potassium but had insignificant p-value for serum sodium levels. Conclusion: The study outcome indicates the potential of melatonin to prevent Vancomycin induced nephrotoxicity by virtue of its antioxidant property.
format	article
author	Shabana Ali Mahwish Qaisarani Kulsoom Farhat Akbar Waheed
author_facet	Shabana Ali Mahwish Qaisarani Kulsoom Farhat Akbar Waheed
author_sort	Shabana Ali
title	STUDY OF PREVENTIVE EFFECT OF MELATONIN ON HIGH DOSE VANCOMYCIN INDUCED NEPHROTOXICITY IN RABBITS
title_short	STUDY OF PREVENTIVE EFFECT OF MELATONIN ON HIGH DOSE VANCOMYCIN INDUCED NEPHROTOXICITY IN RABBITS
title_full	STUDY OF PREVENTIVE EFFECT OF MELATONIN ON HIGH DOSE VANCOMYCIN INDUCED NEPHROTOXICITY IN RABBITS
title_fullStr	STUDY OF PREVENTIVE EFFECT OF MELATONIN ON HIGH DOSE VANCOMYCIN INDUCED NEPHROTOXICITY IN RABBITS
title_full_unstemmed	STUDY OF PREVENTIVE EFFECT OF MELATONIN ON HIGH DOSE VANCOMYCIN INDUCED NEPHROTOXICITY IN RABBITS
title_sort	study of preventive effect of melatonin on high dose vancomycin induced nephrotoxicity in rabbits
publisher	Army Medical College Rawalpindi
publishDate	2018
url	https://doaj.org/article/c0502a461a88433da7d2afa2c57cec99
work_keys_str_mv	AT shabanaali studyofpreventiveeffectofmelatoninonhighdosevancomycininducednephrotoxicityinrabbits AT mahwishqaisarani studyofpreventiveeffectofmelatoninonhighdosevancomycininducednephrotoxicityinrabbits AT kulsoomfarhat studyofpreventiveeffectofmelatoninonhighdosevancomycininducednephrotoxicityinrabbits AT akbarwaheed studyofpreventiveeffectofmelatoninonhighdosevancomycininducednephrotoxicityinrabbits
_version_	1718409992047951872

STUDY OF PREVENTIVE EFFECT OF MELATONIN ON HIGH DOSE VANCOMYCIN INDUCED NEPHROTOXICITY IN RABBITS

Ejemplares similares