Role of AHR Ligands in Skin Homeostasis and Cutaneous Inflammation

Aryl hydrocarbon receptor (AHR) is an important regulator of skin barrier function. It also controls immune-mediated skin responses. The AHR modulates various physiological functions by acting as a sensor that mediates environment–cell interactions, particularly during immune and inflammatory respon...

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Autores principales:	Nieves Fernández-Gallego, Francisco Sánchez-Madrid, Danay Cibrian
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	aryl hydrocarbon receptor cutaneous inflammation immune and inflammatory responses AHR signaling pathways AHR endogenous and exogenous ligands Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/c050c864cfa44083a147a361eb469225
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spelling	oai:doaj.org-article:c050c864cfa44083a147a361eb4692252021-11-25T17:12:22ZRole of AHR Ligands in Skin Homeostasis and Cutaneous Inflammation10.3390/cells101131762073-4409https://doaj.org/article/c050c864cfa44083a147a361eb4692252021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/3176https://doaj.org/toc/2073-4409Aryl hydrocarbon receptor (AHR) is an important regulator of skin barrier function. It also controls immune-mediated skin responses. The AHR modulates various physiological functions by acting as a sensor that mediates environment–cell interactions, particularly during immune and inflammatory responses. Diverse experimental systems have been used to assess the AHR’s role in skin inflammation, including in vitro assays of keratinocyte stimulation and murine models of psoriasis and atopic dermatitis. Similar approaches have addressed the role of AHR ligands, e.g., TCDD, FICZ, and microbiota-derived metabolites, in skin homeostasis and pathology. Tapinarof is a novel AHR-modulating agent that inhibits skin inflammation and enhances skin barrier function. The topical application of tapinarof is being evaluated in clinical trials to treat psoriasis and atopic dermatitis. In the present review, we summarize the effects of natural and synthetic AHR ligands in keratinocytes and inflammatory cells, and their relevance in normal skin homeostasis and cutaneous inflammatory diseases.Nieves Fernández-GallegoFrancisco Sánchez-MadridDanay CibrianMDPI AGarticlearyl hydrocarbon receptorcutaneous inflammationimmune and inflammatory responsesAHR signaling pathwaysAHR endogenous and exogenous ligandsBiology (General)QH301-705.5ENCells, Vol 10, Iss 3176, p 3176 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	aryl hydrocarbon receptor cutaneous inflammation immune and inflammatory responses AHR signaling pathways AHR endogenous and exogenous ligands Biology (General) QH301-705.5
spellingShingle	aryl hydrocarbon receptor cutaneous inflammation immune and inflammatory responses AHR signaling pathways AHR endogenous and exogenous ligands Biology (General) QH301-705.5 Nieves Fernández-Gallego Francisco Sánchez-Madrid Danay Cibrian Role of AHR Ligands in Skin Homeostasis and Cutaneous Inflammation
description	Aryl hydrocarbon receptor (AHR) is an important regulator of skin barrier function. It also controls immune-mediated skin responses. The AHR modulates various physiological functions by acting as a sensor that mediates environment–cell interactions, particularly during immune and inflammatory responses. Diverse experimental systems have been used to assess the AHR’s role in skin inflammation, including in vitro assays of keratinocyte stimulation and murine models of psoriasis and atopic dermatitis. Similar approaches have addressed the role of AHR ligands, e.g., TCDD, FICZ, and microbiota-derived metabolites, in skin homeostasis and pathology. Tapinarof is a novel AHR-modulating agent that inhibits skin inflammation and enhances skin barrier function. The topical application of tapinarof is being evaluated in clinical trials to treat psoriasis and atopic dermatitis. In the present review, we summarize the effects of natural and synthetic AHR ligands in keratinocytes and inflammatory cells, and their relevance in normal skin homeostasis and cutaneous inflammatory diseases.
format	article
author	Nieves Fernández-Gallego Francisco Sánchez-Madrid Danay Cibrian
author_facet	Nieves Fernández-Gallego Francisco Sánchez-Madrid Danay Cibrian
author_sort	Nieves Fernández-Gallego
title	Role of AHR Ligands in Skin Homeostasis and Cutaneous Inflammation
title_short	Role of AHR Ligands in Skin Homeostasis and Cutaneous Inflammation
title_full	Role of AHR Ligands in Skin Homeostasis and Cutaneous Inflammation
title_fullStr	Role of AHR Ligands in Skin Homeostasis and Cutaneous Inflammation
title_full_unstemmed	Role of AHR Ligands in Skin Homeostasis and Cutaneous Inflammation
title_sort	role of ahr ligands in skin homeostasis and cutaneous inflammation
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c050c864cfa44083a147a361eb469225
work_keys_str_mv	AT nievesfernandezgallego roleofahrligandsinskinhomeostasisandcutaneousinflammation AT franciscosanchezmadrid roleofahrligandsinskinhomeostasisandcutaneousinflammation AT danaycibrian roleofahrligandsinskinhomeostasisandcutaneousinflammation
_version_	1718412675432579072

Role of AHR Ligands in Skin Homeostasis and Cutaneous Inflammation

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