The RNA-binding protein vigilin regulates VLDL secretion through modulation of Apob mRNA translation

RNA-binding proteins (RBP) are an emerging group of post-translational regulators. Here the authors show that the RBP vigilin regulates translation of mRNA encoding for proatherogenic proteins—apoB, apoC-III and fibronectin—representing a potential therapeutic target in cardiovascular diseases.

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Autores principales:	Mehrpouya B. Mobin, Stefanie Gerstberger, Daniel Teupser, Benedetta Campana, Klaus Charisse, Markus H. Heim, Muthiah Manoharan, Thomas Tuschl, Markus Stoffel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c051eb85ce414e1e9cc79d1170727a36
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spelling	oai:doaj.org-article:c051eb85ce414e1e9cc79d1170727a362021-12-02T16:49:57ZThe RNA-binding protein vigilin regulates VLDL secretion through modulation of Apob mRNA translation10.1038/ncomms128482041-1723https://doaj.org/article/c051eb85ce414e1e9cc79d1170727a362016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12848https://doaj.org/toc/2041-1723RNA-binding proteins (RBP) are an emerging group of post-translational regulators. Here the authors show that the RBP vigilin regulates translation of mRNA encoding for proatherogenic proteins—apoB, apoC-III and fibronectin—representing a potential therapeutic target in cardiovascular diseases.Mehrpouya B. MobinStefanie GerstbergerDaniel TeupserBenedetta CampanaKlaus CharisseMarkus H. HeimMuthiah ManoharanThomas TuschlMarkus StoffelNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mehrpouya B. Mobin Stefanie Gerstberger Daniel Teupser Benedetta Campana Klaus Charisse Markus H. Heim Muthiah Manoharan Thomas Tuschl Markus Stoffel The RNA-binding protein vigilin regulates VLDL secretion through modulation of Apob mRNA translation
description	RNA-binding proteins (RBP) are an emerging group of post-translational regulators. Here the authors show that the RBP vigilin regulates translation of mRNA encoding for proatherogenic proteins—apoB, apoC-III and fibronectin—representing a potential therapeutic target in cardiovascular diseases.
format	article
author	Mehrpouya B. Mobin Stefanie Gerstberger Daniel Teupser Benedetta Campana Klaus Charisse Markus H. Heim Muthiah Manoharan Thomas Tuschl Markus Stoffel
author_facet	Mehrpouya B. Mobin Stefanie Gerstberger Daniel Teupser Benedetta Campana Klaus Charisse Markus H. Heim Muthiah Manoharan Thomas Tuschl Markus Stoffel
author_sort	Mehrpouya B. Mobin
title	The RNA-binding protein vigilin regulates VLDL secretion through modulation of Apob mRNA translation
title_short	The RNA-binding protein vigilin regulates VLDL secretion through modulation of Apob mRNA translation
title_full	The RNA-binding protein vigilin regulates VLDL secretion through modulation of Apob mRNA translation
title_fullStr	The RNA-binding protein vigilin regulates VLDL secretion through modulation of Apob mRNA translation
title_full_unstemmed	The RNA-binding protein vigilin regulates VLDL secretion through modulation of Apob mRNA translation
title_sort	rna-binding protein vigilin regulates vldl secretion through modulation of apob mrna translation
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/c051eb85ce414e1e9cc79d1170727a36
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The RNA-binding protein vigilin regulates VLDL secretion through modulation of Apob mRNA translation

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