The RNA-binding protein vigilin regulates VLDL secretion through modulation of Apob mRNA translation

The RNA-binding protein vigilin regulates VLDL secretion through modulation of Apob mRNA translation

RNA-binding proteins (RBP) are an emerging group of post-translational regulators. Here the authors show that the RBP vigilin regulates translation of mRNA encoding for proatherogenic proteins—apoB, apoC-III and fibronectin—representing a potential therapeutic target in cardiovascular diseases.

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Autores principales: Mehrpouya B. Mobin, Stefanie Gerstberger, Daniel Teupser, Benedetta Campana, Klaus Charisse, Markus H. Heim, Muthiah Manoharan, Thomas Tuschl, Markus Stoffel
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Science
Q
Acceso en línea:https://doaj.org/article/c051eb85ce414e1e9cc79d1170727a36
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