Human age and skin physiology shape diversity and abundance of Archaea on skin

Abstract The human skin microbiome acts as an important barrier protecting our body from pathogens and other environmental influences. Recent investigations have provided evidence that Archaea are a constant but highly variable component of the human skin microbiome, yet factors that determine their...

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Autores principales:	Christine Moissl-Eichinger, Alexander J. Probst, Giovanni Birarda, Anna Auerbach, Kaisa Koskinen, Peter Wolf, Hoi-Ying N. Holman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c0588cde4f9c45e895fadd73794e17ad
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spelling	oai:doaj.org-article:c0588cde4f9c45e895fadd73794e17ad2021-12-02T11:53:09ZHuman age and skin physiology shape diversity and abundance of Archaea on skin10.1038/s41598-017-04197-42045-2322https://doaj.org/article/c0588cde4f9c45e895fadd73794e17ad2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04197-4https://doaj.org/toc/2045-2322Abstract The human skin microbiome acts as an important barrier protecting our body from pathogens and other environmental influences. Recent investigations have provided evidence that Archaea are a constant but highly variable component of the human skin microbiome, yet factors that determine their abundance changes are unknown. Here, we tested the hypothesis that the abundance of archaea on human skin is influenced by human age and skin physiology by quantitative PCR of 51 different skin samples taken from human subjects of various age. Our results reveal that archaea are more abundant in human subjects either older than 60 years or younger than 12 years as compared to middle-aged human subjects. These results, together with results obtained from spectroscopy analysis, allowed us gain first insights into a potential link of lower sebum levels and lipid content and thus reduced skin moisture with an increase in archaeal signatures. Amplicon sequencing of selected samples revealed the prevalence of specific eury- and mainly thaumarchaeal taxa, represented by a core archaeome of the human skin.Christine Moissl-EichingerAlexander J. ProbstGiovanni BirardaAnna AuerbachKaisa KoskinenPeter WolfHoi-Ying N. HolmanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Christine Moissl-Eichinger Alexander J. Probst Giovanni Birarda Anna Auerbach Kaisa Koskinen Peter Wolf Hoi-Ying N. Holman Human age and skin physiology shape diversity and abundance of Archaea on skin
description	Abstract The human skin microbiome acts as an important barrier protecting our body from pathogens and other environmental influences. Recent investigations have provided evidence that Archaea are a constant but highly variable component of the human skin microbiome, yet factors that determine their abundance changes are unknown. Here, we tested the hypothesis that the abundance of archaea on human skin is influenced by human age and skin physiology by quantitative PCR of 51 different skin samples taken from human subjects of various age. Our results reveal that archaea are more abundant in human subjects either older than 60 years or younger than 12 years as compared to middle-aged human subjects. These results, together with results obtained from spectroscopy analysis, allowed us gain first insights into a potential link of lower sebum levels and lipid content and thus reduced skin moisture with an increase in archaeal signatures. Amplicon sequencing of selected samples revealed the prevalence of specific eury- and mainly thaumarchaeal taxa, represented by a core archaeome of the human skin.
format	article
author	Christine Moissl-Eichinger Alexander J. Probst Giovanni Birarda Anna Auerbach Kaisa Koskinen Peter Wolf Hoi-Ying N. Holman
author_facet	Christine Moissl-Eichinger Alexander J. Probst Giovanni Birarda Anna Auerbach Kaisa Koskinen Peter Wolf Hoi-Ying N. Holman
author_sort	Christine Moissl-Eichinger
title	Human age and skin physiology shape diversity and abundance of Archaea on skin
title_short	Human age and skin physiology shape diversity and abundance of Archaea on skin
title_full	Human age and skin physiology shape diversity and abundance of Archaea on skin
title_fullStr	Human age and skin physiology shape diversity and abundance of Archaea on skin
title_full_unstemmed	Human age and skin physiology shape diversity and abundance of Archaea on skin
title_sort	human age and skin physiology shape diversity and abundance of archaea on skin
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c0588cde4f9c45e895fadd73794e17ad
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Human age and skin physiology shape diversity and abundance of Archaea on skin

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