ZBP1 not RIPK1 mediates tumor necroptosis in breast cancer

ZBP1 not RIPK1 mediates tumor necroptosis in breast cancer

Tumour necroptosis is regulated by RIPK3 during tumour development. Here the authors show that ZBP1 is an upstream mediator of RIPK3 in tumour necroptosis and that glucose deprivation induces the release of mitochondrial DNA, which binds to ZBP1 to activate ZBP1-mediated necroptosis in breast cancer...

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Autores principales: Jin Young Baik, Zhaoshan Liu, Delong Jiao, Hyung-Joon Kwon, Jiong Yan, Chamila Kadigamuwa, Moran Choe, Ross Lake, Michael Kruhlak, Mayank Tandon, Zhenyu Cai, Swati Choksi, Zheng-gang Liu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/c059cce4955c4850a438f4f3231f7e07
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spelling oai:doaj.org-article:c059cce4955c4850a438f4f3231f7e072021-12-02T14:35:39ZZBP1 not RIPK1 mediates tumor necroptosis in breast cancer10.1038/s41467-021-23004-32041-1723https://doaj.org/article/c059cce4955c4850a438f4f3231f7e072021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23004-3https://doaj.org/toc/2041-1723Tumour necroptosis is regulated by RIPK3 during tumour development. Here the authors show that ZBP1 is an upstream mediator of RIPK3 in tumour necroptosis and that glucose deprivation induces the release of mitochondrial DNA, which binds to ZBP1 to activate ZBP1-mediated necroptosis in breast cancer.Jin Young BaikZhaoshan LiuDelong JiaoHyung-Joon KwonJiong YanChamila KadigamuwaMoran ChoeRoss LakeMichael KruhlakMayank TandonZhenyu CaiSwati ChoksiZheng-gang LiuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jin Young Baik
Zhaoshan Liu
Delong Jiao
Hyung-Joon Kwon
Jiong Yan
Chamila Kadigamuwa
Moran Choe
Ross Lake
Michael Kruhlak
Mayank Tandon
Zhenyu Cai
Swati Choksi
Zheng-gang Liu
ZBP1 not RIPK1 mediates tumor necroptosis in breast cancer
description Tumour necroptosis is regulated by RIPK3 during tumour development. Here the authors show that ZBP1 is an upstream mediator of RIPK3 in tumour necroptosis and that glucose deprivation induces the release of mitochondrial DNA, which binds to ZBP1 to activate ZBP1-mediated necroptosis in breast cancer.
format article
author Jin Young Baik
Zhaoshan Liu
Delong Jiao
Hyung-Joon Kwon
Jiong Yan
Chamila Kadigamuwa
Moran Choe
Ross Lake
Michael Kruhlak
Mayank Tandon
Zhenyu Cai
Swati Choksi
Zheng-gang Liu
author_facet Jin Young Baik
Zhaoshan Liu
Delong Jiao
Hyung-Joon Kwon
Jiong Yan
Chamila Kadigamuwa
Moran Choe
Ross Lake
Michael Kruhlak
Mayank Tandon
Zhenyu Cai
Swati Choksi
Zheng-gang Liu
author_sort Jin Young Baik
title ZBP1 not RIPK1 mediates tumor necroptosis in breast cancer
title_short ZBP1 not RIPK1 mediates tumor necroptosis in breast cancer
title_full ZBP1 not RIPK1 mediates tumor necroptosis in breast cancer
title_fullStr ZBP1 not RIPK1 mediates tumor necroptosis in breast cancer
title_full_unstemmed ZBP1 not RIPK1 mediates tumor necroptosis in breast cancer
title_sort zbp1 not ripk1 mediates tumor necroptosis in breast cancer
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/c059cce4955c4850a438f4f3231f7e07
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