Non-Coding RNAs: Master Regulators of Inflammasomes in Inflammatory Diseases

Wei Wang, Ni Yang, Yu-Hang Yang, Ri Wen, Chun-Feng Liu, Tie-Ning Zhang Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, People’s Republic of ChinaCorrespondence: Chun-Feng Liu; Tie-Ning ZhangDepartment of Pediatrics, Shengjing Hospital of China Medical University,...

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Autores principales:	Wang W, Yang N, Yang YH, Wen R, Liu CF, Zhang TN
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	ncrnas inflammasomes infection immune inflammation fibrosis Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/c05a83c4eeaf4652b8102227e58a1066
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spelling	oai:doaj.org-article:c05a83c4eeaf4652b8102227e58a10662021-12-02T15:18:19ZNon-Coding RNAs: Master Regulators of Inflammasomes in Inflammatory Diseases1178-7031https://doaj.org/article/c05a83c4eeaf4652b8102227e58a10662021-09-01T00:00:00Zhttps://www.dovepress.com/non-coding-rnas-master-regulators-of-inflammasomes-in-inflammatory-dis-peer-reviewed-fulltext-article-JIRhttps://doaj.org/toc/1178-7031Wei Wang, Ni Yang, Yu-Hang Yang, Ri Wen, Chun-Feng Liu, Tie-Ning Zhang Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, People’s Republic of ChinaCorrespondence: Chun-Feng Liu; Tie-Ning ZhangDepartment of Pediatrics, Shengjing Hospital of China Medical University, No. 36 SanHao Street, Shenyang City, Liaoning Province, 110004, People’s Republic of ChinaTel +86-18940251826; +86-18940253339Email zhliu258@hotmail.com; cmuztn@vip.qq.comAbstract: Emerging data indicates that non-coding RNAs (ncRNAs) represent more than just “junk sequences” of the genome and have been found to be involved in multiple diseases by regulating various biological process, including the activation of inflammasomes. As an important aspect of innate immunity, inflammasomes are large immune multiprotein complexes that tightly regulate the production of pro-inflammatory cytokines and mediate pyroptosis; the activation of the inflammasomes is a vital biological process in inflammatory diseases. Recent studies have emphasized the function of ncRNAs in the fine control of inflammasomes activation either by directly targeting components of the inflammasomes or by controlling the activity of various factors that control the activation of inflammasomes; consequently, ncRNAs may represent potential therapeutic targets for inflammatory diseases. Understanding the precise role of ncRNAs in controlling the activation of inflammasomes will help us to design targeted therapies for multiple inflammatory diseases. In this review, we summarize the regulatory role and therapeutic potential of ncRNAs in the activation of inflammasomes by focusing on a range of inflammatory diseases, including microbial infection, sterile inflammatory diseases, and fibrosis-related diseases. Our goal is to provide new ideas and perspectives for future research.Keywords: ncRNAs, inflammasomes, infection, immune, inflammation, fibrosisWang WYang NYang YHWen RLiu CFZhang TNDove Medical PressarticlencrnasinflammasomesinfectionimmuneinflammationfibrosisPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 14, Pp 5023-5050 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ncrnas inflammasomes infection immune inflammation fibrosis Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	ncrnas inflammasomes infection immune inflammation fibrosis Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Wang W Yang N Yang YH Wen R Liu CF Zhang TN Non-Coding RNAs: Master Regulators of Inflammasomes in Inflammatory Diseases
description	Wei Wang, Ni Yang, Yu-Hang Yang, Ri Wen, Chun-Feng Liu, Tie-Ning Zhang Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, People’s Republic of ChinaCorrespondence: Chun-Feng Liu; Tie-Ning ZhangDepartment of Pediatrics, Shengjing Hospital of China Medical University, No. 36 SanHao Street, Shenyang City, Liaoning Province, 110004, People’s Republic of ChinaTel +86-18940251826; +86-18940253339Email zhliu258@hotmail.com; cmuztn@vip.qq.comAbstract: Emerging data indicates that non-coding RNAs (ncRNAs) represent more than just “junk sequences” of the genome and have been found to be involved in multiple diseases by regulating various biological process, including the activation of inflammasomes. As an important aspect of innate immunity, inflammasomes are large immune multiprotein complexes that tightly regulate the production of pro-inflammatory cytokines and mediate pyroptosis; the activation of the inflammasomes is a vital biological process in inflammatory diseases. Recent studies have emphasized the function of ncRNAs in the fine control of inflammasomes activation either by directly targeting components of the inflammasomes or by controlling the activity of various factors that control the activation of inflammasomes; consequently, ncRNAs may represent potential therapeutic targets for inflammatory diseases. Understanding the precise role of ncRNAs in controlling the activation of inflammasomes will help us to design targeted therapies for multiple inflammatory diseases. In this review, we summarize the regulatory role and therapeutic potential of ncRNAs in the activation of inflammasomes by focusing on a range of inflammatory diseases, including microbial infection, sterile inflammatory diseases, and fibrosis-related diseases. Our goal is to provide new ideas and perspectives for future research.Keywords: ncRNAs, inflammasomes, infection, immune, inflammation, fibrosis
format	article
author	Wang W Yang N Yang YH Wen R Liu CF Zhang TN
author_facet	Wang W Yang N Yang YH Wen R Liu CF Zhang TN
author_sort	Wang W
title	Non-Coding RNAs: Master Regulators of Inflammasomes in Inflammatory Diseases
title_short	Non-Coding RNAs: Master Regulators of Inflammasomes in Inflammatory Diseases
title_full	Non-Coding RNAs: Master Regulators of Inflammasomes in Inflammatory Diseases
title_fullStr	Non-Coding RNAs: Master Regulators of Inflammasomes in Inflammatory Diseases
title_full_unstemmed	Non-Coding RNAs: Master Regulators of Inflammasomes in Inflammatory Diseases
title_sort	non-coding rnas: master regulators of inflammasomes in inflammatory diseases
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/c05a83c4eeaf4652b8102227e58a1066
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Non-Coding RNAs: Master Regulators of Inflammasomes in Inflammatory Diseases

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