Potential of Bone-Marrow-Derived Mesenchymal Stem Cells for Maxillofacial and Periodontal Regeneration: A Narrative Review

Bone-marrow-derived mesenchymal stem cells (BM-MSCs) are one of the most widely studied postnatal stem cell populations and are considered to utilize more frequently in cell-based therapy and cancer. These types of stem cells can undergo multilineage differentiation including blood cells, cardiac ce...

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Autores principales:	Hamid Reza Khorasani, Mahboubeh Sanchouli, Javad Mehrani, Davood Sabour
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Dentistry RK1-715
Acceso en línea:	https://doaj.org/article/c05b77a856e847c3b83205a7bd15c06a
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spelling	oai:doaj.org-article:c05b77a856e847c3b83205a7bd15c06a2021-11-22T01:10:12ZPotential of Bone-Marrow-Derived Mesenchymal Stem Cells for Maxillofacial and Periodontal Regeneration: A Narrative Review1687-873610.1155/2021/4759492https://doaj.org/article/c05b77a856e847c3b83205a7bd15c06a2021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/4759492https://doaj.org/toc/1687-8736Bone-marrow-derived mesenchymal stem cells (BM-MSCs) are one of the most widely studied postnatal stem cell populations and are considered to utilize more frequently in cell-based therapy and cancer. These types of stem cells can undergo multilineage differentiation including blood cells, cardiac cells, and osteogenic cells differentiation, thus providing an alternative source of mesenchymal stem cells (MSCs) for tissue engineering and personalized medicine. Despite the ability to reprogram human adult somatic cells to induced pluripotent stem cells (iPSCs) in culture which provided a great opportunity and opened the new door for establishing the in vitro disease modeling and generating an unlimited source for cell base therapy, using MSCs for regeneration purposes still have a great chance to cure diseases. In this review, we discuss the important issues in MSCs biology including the origin and functions of MSCs and their application for craniofacial and periodontal tissue regeneration, discuss the potential and clinical applications of this type of stem cells in differentiation to maxillofacial bone and cartilage in vitro, and address important future hopes and challenges in this field.Hamid Reza KhorasaniMahboubeh SanchouliJavad MehraniDavood SabourHindawi LimitedarticleDentistryRK1-715ENInternational Journal of Dentistry, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Dentistry RK1-715
spellingShingle	Dentistry RK1-715 Hamid Reza Khorasani Mahboubeh Sanchouli Javad Mehrani Davood Sabour Potential of Bone-Marrow-Derived Mesenchymal Stem Cells for Maxillofacial and Periodontal Regeneration: A Narrative Review
description	Bone-marrow-derived mesenchymal stem cells (BM-MSCs) are one of the most widely studied postnatal stem cell populations and are considered to utilize more frequently in cell-based therapy and cancer. These types of stem cells can undergo multilineage differentiation including blood cells, cardiac cells, and osteogenic cells differentiation, thus providing an alternative source of mesenchymal stem cells (MSCs) for tissue engineering and personalized medicine. Despite the ability to reprogram human adult somatic cells to induced pluripotent stem cells (iPSCs) in culture which provided a great opportunity and opened the new door for establishing the in vitro disease modeling and generating an unlimited source for cell base therapy, using MSCs for regeneration purposes still have a great chance to cure diseases. In this review, we discuss the important issues in MSCs biology including the origin and functions of MSCs and their application for craniofacial and periodontal tissue regeneration, discuss the potential and clinical applications of this type of stem cells in differentiation to maxillofacial bone and cartilage in vitro, and address important future hopes and challenges in this field.
format	article
author	Hamid Reza Khorasani Mahboubeh Sanchouli Javad Mehrani Davood Sabour
author_facet	Hamid Reza Khorasani Mahboubeh Sanchouli Javad Mehrani Davood Sabour
author_sort	Hamid Reza Khorasani
title	Potential of Bone-Marrow-Derived Mesenchymal Stem Cells for Maxillofacial and Periodontal Regeneration: A Narrative Review
title_short	Potential of Bone-Marrow-Derived Mesenchymal Stem Cells for Maxillofacial and Periodontal Regeneration: A Narrative Review
title_full	Potential of Bone-Marrow-Derived Mesenchymal Stem Cells for Maxillofacial and Periodontal Regeneration: A Narrative Review
title_fullStr	Potential of Bone-Marrow-Derived Mesenchymal Stem Cells for Maxillofacial and Periodontal Regeneration: A Narrative Review
title_full_unstemmed	Potential of Bone-Marrow-Derived Mesenchymal Stem Cells for Maxillofacial and Periodontal Regeneration: A Narrative Review
title_sort	potential of bone-marrow-derived mesenchymal stem cells for maxillofacial and periodontal regeneration: a narrative review
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/c05b77a856e847c3b83205a7bd15c06a
work_keys_str_mv	AT hamidrezakhorasani potentialofbonemarrowderivedmesenchymalstemcellsformaxillofacialandperiodontalregenerationanarrativereview AT mahboubehsanchouli potentialofbonemarrowderivedmesenchymalstemcellsformaxillofacialandperiodontalregenerationanarrativereview AT javadmehrani potentialofbonemarrowderivedmesenchymalstemcellsformaxillofacialandperiodontalregenerationanarrativereview AT davoodsabour potentialofbonemarrowderivedmesenchymalstemcellsformaxillofacialandperiodontalregenerationanarrativereview
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Potential of Bone-Marrow-Derived Mesenchymal Stem Cells for Maxillofacial and Periodontal Regeneration: A Narrative Review

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