A comparison of hemodynamic effects of Midazolam and Thiopental in induction of anesthesia

Objective: Although thiopental sodium (Nesdonal) is an almost ideal drug for induction of anesthesia, but it mostly cause hemodynamic changes such as hypotension. The objective of this study is to compare hemodynamic effects of thiopental sodium and Midazolam (From Benzodiazpine family) in order to...

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Autores principales:	E Alijan Poor, SM Rabiei, S Mir Shekari
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2000
Materias:	thiopental sodium midazolam systolic blood pressure diastolic blood pressure heart rate Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/c05ba08a74e845729daea7393a0cdc9c
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spelling	oai:doaj.org-article:c05ba08a74e845729daea7393a0cdc9c2021-11-10T09:22:07ZA comparison of hemodynamic effects of Midazolam and Thiopental in induction of anesthesia1561-41072251-7170https://doaj.org/article/c05ba08a74e845729daea7393a0cdc9c2000-04-01T00:00:00Zhttp://jbums.org/article-1-2909-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170Objective: Although thiopental sodium (Nesdonal) is an almost ideal drug for induction of anesthesia, but it mostly cause hemodynamic changes such as hypotension. The objective of this study is to compare hemodynamic effects of thiopental sodium and Midazolam (From Benzodiazpine family) in order to replace it with thiopental when necessary. Methods: 50 patients in ASA I were divided into two groups (Each group 25 persons) randomly subjects in both groups were administered with premedication with an equal dose per patient’s weight. In first group anesthesia was started with thiopental sodium 4-5 mg/kg with succinylcholine and in the second group with Midazolam 0.25-0.3 mg/kg with succinylcholine and intubation was done after a given time. Heart rate and blood pressure were recorded for both groups at special times and data were compared with each other. Findings: In this study pulse rate of 20% of patients who received thiopental sodium were increased to 20 beats/min. It was 12% for Midazolam group the changes (P=0.000) were meaningful. An increase of systolic blood pressure more than 40 mmHg from base after intubation with thiopental sodium in 24% of persons (P=0.011) and 2 min after intubation in 20% persons (P=0.048) were meaningful. There were no such variations in Midazolam group. Data shows that any rise or fall in blood pressure and heart rate observed with thiopental sodium is more than that with Midazolam. Conclusion: Considering this research and the other studies show more record of hemodynamic condition of Midazolam than thiopental sodium. Therefore, in patients with dangerous hemodynamic variations, especially decreasing of blood pressure only induction with Midazolam or a combination of Midazolam and thiopental (For rapid onset action) as co-induction is useful.E Alijan PoorSM RabieiS Mir ShekariBabol University of Medical Sciencesarticlethiopental sodiummidazolamsystolic blood pressurediastolic blood pressureheart rateMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 2, Iss 2, Pp 27-32 (2000)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	thiopental sodium midazolam systolic blood pressure diastolic blood pressure heart rate Medicine R Medicine (General) R5-920
spellingShingle	thiopental sodium midazolam systolic blood pressure diastolic blood pressure heart rate Medicine R Medicine (General) R5-920 E Alijan Poor SM Rabiei S Mir Shekari A comparison of hemodynamic effects of Midazolam and Thiopental in induction of anesthesia
description	Objective: Although thiopental sodium (Nesdonal) is an almost ideal drug for induction of anesthesia, but it mostly cause hemodynamic changes such as hypotension. The objective of this study is to compare hemodynamic effects of thiopental sodium and Midazolam (From Benzodiazpine family) in order to replace it with thiopental when necessary. Methods: 50 patients in ASA I were divided into two groups (Each group 25 persons) randomly subjects in both groups were administered with premedication with an equal dose per patient’s weight. In first group anesthesia was started with thiopental sodium 4-5 mg/kg with succinylcholine and in the second group with Midazolam 0.25-0.3 mg/kg with succinylcholine and intubation was done after a given time. Heart rate and blood pressure were recorded for both groups at special times and data were compared with each other. Findings: In this study pulse rate of 20% of patients who received thiopental sodium were increased to 20 beats/min. It was 12% for Midazolam group the changes (P=0.000) were meaningful. An increase of systolic blood pressure more than 40 mmHg from base after intubation with thiopental sodium in 24% of persons (P=0.011) and 2 min after intubation in 20% persons (P=0.048) were meaningful. There were no such variations in Midazolam group. Data shows that any rise or fall in blood pressure and heart rate observed with thiopental sodium is more than that with Midazolam. Conclusion: Considering this research and the other studies show more record of hemodynamic condition of Midazolam than thiopental sodium. Therefore, in patients with dangerous hemodynamic variations, especially decreasing of blood pressure only induction with Midazolam or a combination of Midazolam and thiopental (For rapid onset action) as co-induction is useful.
format	article
author	E Alijan Poor SM Rabiei S Mir Shekari
author_facet	E Alijan Poor SM Rabiei S Mir Shekari
author_sort	E Alijan Poor
title	A comparison of hemodynamic effects of Midazolam and Thiopental in induction of anesthesia
title_short	A comparison of hemodynamic effects of Midazolam and Thiopental in induction of anesthesia
title_full	A comparison of hemodynamic effects of Midazolam and Thiopental in induction of anesthesia
title_fullStr	A comparison of hemodynamic effects of Midazolam and Thiopental in induction of anesthesia
title_full_unstemmed	A comparison of hemodynamic effects of Midazolam and Thiopental in induction of anesthesia
title_sort	comparison of hemodynamic effects of midazolam and thiopental in induction of anesthesia
publisher	Babol University of Medical Sciences
publishDate	2000
url	https://doaj.org/article/c05ba08a74e845729daea7393a0cdc9c
work_keys_str_mv	AT ealijanpoor acomparisonofhemodynamiceffectsofmidazolamandthiopentalininductionofanesthesia AT smrabiei acomparisonofhemodynamiceffectsofmidazolamandthiopentalininductionofanesthesia AT smirshekari acomparisonofhemodynamiceffectsofmidazolamandthiopentalininductionofanesthesia AT ealijanpoor comparisonofhemodynamiceffectsofmidazolamandthiopentalininductionofanesthesia AT smrabiei comparisonofhemodynamiceffectsofmidazolamandthiopentalininductionofanesthesia AT smirshekari comparisonofhemodynamiceffectsofmidazolamandthiopentalininductionofanesthesia
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A comparison of hemodynamic effects of Midazolam and Thiopental in induction of anesthesia

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