Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers

The AAA+ ATPase p97 is an essential hexameric protein with multiple protein interaction partners and cellular functions. Here, the authors use interaction mapping to examine partner proteins of this large complex, and assess the effects of these proteins on the disassembly of the p97 complex.

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Autores principales:	Anup Arumughan, Yvette Roske, Carolin Barth, Laura Lleras Forero, Kenny Bravo-Rodriguez, Alexandra Redel, Simona Kostova, Erik McShane, Robert Opitz, Katja Faelber, Kirstin Rau, Thorsten Mielke, Oliver Daumke, Matthias Selbach, Elsa Sanchez-Garcia, Oliver Rocks, Daniela Panáková, Udo Heinemann, Erich E. Wanker
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c05c3467f02d4df0b4320632445b06fa
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spelling	oai:doaj.org-article:c05c3467f02d4df0b4320632445b06fa2021-12-02T16:56:45ZQuantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers10.1038/ncomms130472041-1723https://doaj.org/article/c05c3467f02d4df0b4320632445b06fa2016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms13047https://doaj.org/toc/2041-1723The AAA+ ATPase p97 is an essential hexameric protein with multiple protein interaction partners and cellular functions. Here, the authors use interaction mapping to examine partner proteins of this large complex, and assess the effects of these proteins on the disassembly of the p97 complex.Anup ArumughanYvette RoskeCarolin BarthLaura Lleras ForeroKenny Bravo-RodriguezAlexandra RedelSimona KostovaErik McShaneRobert OpitzKatja FaelberKirstin RauThorsten MielkeOliver DaumkeMatthias SelbachElsa Sanchez-GarciaOliver RocksDaniela PanákováUdo HeinemannErich E. WankerNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anup Arumughan Yvette Roske Carolin Barth Laura Lleras Forero Kenny Bravo-Rodriguez Alexandra Redel Simona Kostova Erik McShane Robert Opitz Katja Faelber Kirstin Rau Thorsten Mielke Oliver Daumke Matthias Selbach Elsa Sanchez-Garcia Oliver Rocks Daniela Panáková Udo Heinemann Erich E. Wanker Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers
description	The AAA+ ATPase p97 is an essential hexameric protein with multiple protein interaction partners and cellular functions. Here, the authors use interaction mapping to examine partner proteins of this large complex, and assess the effects of these proteins on the disassembly of the p97 complex.
format	article
author	Anup Arumughan Yvette Roske Carolin Barth Laura Lleras Forero Kenny Bravo-Rodriguez Alexandra Redel Simona Kostova Erik McShane Robert Opitz Katja Faelber Kirstin Rau Thorsten Mielke Oliver Daumke Matthias Selbach Elsa Sanchez-Garcia Oliver Rocks Daniela Panáková Udo Heinemann Erich E. Wanker
author_facet	Anup Arumughan Yvette Roske Carolin Barth Laura Lleras Forero Kenny Bravo-Rodriguez Alexandra Redel Simona Kostova Erik McShane Robert Opitz Katja Faelber Kirstin Rau Thorsten Mielke Oliver Daumke Matthias Selbach Elsa Sanchez-Garcia Oliver Rocks Daniela Panáková Udo Heinemann Erich E. Wanker
author_sort	Anup Arumughan
title	Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers
title_short	Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers
title_full	Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers
title_fullStr	Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers
title_full_unstemmed	Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers
title_sort	quantitative interaction mapping reveals an extended ubx domain in aspl that disrupts functional p97 hexamers
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/c05c3467f02d4df0b4320632445b06fa
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Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers

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